(Q36544917)

14 August 2017

1 reference

title

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues (English)

1 reference

alternative mRNA splicing, via spliceosome

14 August 2017

main subject

1 reference

based on heuristic

inferred from title

author

Vijayalakshmi Ravindranath

4

object named as

Vijayalakshmi Ravindranath

1 reference

14 August 2017

Cheri M Turman

1

1 reference

14 August 2017

Jade M Hatley

2

1 reference

14 August 2017

Daniel J Ryder

3

1 reference

14 August 2017

Henry W Strobel

5

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14 August 2017

language of work or name

English

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publication date

1 June 2006

1 reference

Expert Opinion on Drug Metabolism & Toxicology

14 August 2017

published in

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14 August 2017

volume

2

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14 August 2017

issue

3

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14 August 2017

page(s)

399-418

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Expression of cytochromes P450 4F4 and 4F5 in infection and injury models of inflammation

14 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Inflammatory prompts produce isoform-specific changes in the expression of leukotriene B(4) omega-hydroxylases in rat liver and kidney.

21 January 2018

1 reference

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Progress in psychiatry (2).

21 January 2018

1 reference

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Progress in psychiatry (1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Pharmacogenetics of the major polymorphic metabolizing enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Pharmacokinetic drug interactions with phenytoin (Part I).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Active drug metabolites in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Cytochromes P450 and metabolism of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Metabolism-based drug-drug interactions: what determines individual variability in cytochrome P450 induction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Pharmacogenetics-based new therapeutic concepts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

The evolving roles of alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Isolation and characterization of a novel cytochrome P-450-like pseudogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Mechanisms of alternative pre-messenger RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Listening to silence and understanding nonsense: exonic mutations that affect splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Constitutive expression and localization of cytochrome P-450 1A1 in rat and human brain: presence of a splice variant form in human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Identification of a novel splice-site mutation in the CYP1A2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Expression and alternative splicing of the cytochrome P-450 CYP2A7

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

A novel polymorphic cytochrome P450 formed by splicing of CYP3A7 and the pseudogene CYP3AP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

RNA molecules containing exons originating from different members of the cytochrome P450 2C gene subfamily (CYP2C) in human epidermis and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Intergenic mRNA molecules resulting from trans-splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Computational analysis of candidate intron regulatory elements for tissue-specific alternative pre-mRNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Multiple splicing events involved in regulation of human aromatase expression by a novel promoter, I.6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

New proteins in the rat CYP2B subfamily: presence in liver microsomes of the constitutive CYP2B3 protein and the phenobarbital-inducible protein product of alternatively spliced CYP2B2 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Molecular cloning of cDNA for guinea pig CYP1A2 comparison with guinea pig CYP1A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

The metabolism of xenobiotics by certain extrahepatic organs and its relation to toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Alternative RNA splicing in the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Human cytochromes P450: problems and prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Recent developments in hepatic drug oxidation. Implications for clinical pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Cytochromes P450 in brain: function and significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

The effect of quinidine on the analgesic effect of codeine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Three new alternative splicing variants of human cytochrome P450 2D6 mRNA in human extratumoral liver tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Alternative splicing patterns of CYP2D genes in human brain and neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Induction of cytochrome P4501A1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

21 January 2018

CYP1A1: friend or foe?

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Expression, induction and regulation of the cytochrome P450 monooxygenase system in the rat glioma C6 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Potential role of cerebral cytochrome P450 in clinical pharmacokinetics: modulation by endogenous compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

ASAP: the Alternative Splicing Annotation Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Expression of CYP1A1 and CYP1A2 genes in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

The human CYP2C locus: a prototype for intergenic and exon repetition splicing events

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Intergenic transcripts containing a novel human cytochrome P450 2C exon 1 spliced to sequences from the CYP2C9 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Exon skipping and circular RNA formation in transcripts of the human cytochrome P-450 2C18 gene in epidermis and of the rat androgen binding protein gene in testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Phenotyping-genotyping of alternatively spliced genes in one step: study of CYP3A5*3 polymorphism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Bilateral laparoscopic adrenalectomy for congenital adrenal hyperplasia with severe hypertension, resulting from two novel mutations in splice donor sites of CYP11B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Two intronic mutations cause 17-hydroxylase deficiency by disrupting splice acceptor sites: direct demonstration of aberrant splicing and absent enzyme activity by expression of the entire CYP17 gene in HEK-293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Identification of a novel splicing mutation and 1-bp deletion in the 17alpha-hydroxylase gene of Japanese patients with 17alpha-hydroxylase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Tissue-Specific Promoters Regulate Aromatase Cytochrome P450 Gene Expression in Human Ovary and Fetal Tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Multiple transcripts of the CYP21 gene are generated by the mutation of the splicing donor site in intron 2 from GT to AT in 21-hydroxylase deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

A novel Arg362Ser mutation in the sterol 27-hydroxylase gene (CYP27): its effects on pre-mRNA splicing and enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Biochemical mechanisms in chemical-induced lung injury: roles of metabolic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Enzymatic activation of chemicals to toxic metabolites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Silent nucleotide substitution in the sterol 27-hydroxylase gene (CYP 27) leads to alternative pre-mRNA splicing by activating a cryptic 5' splice site at the mutant codon in cerebrotendinous xanthomatosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Exon skipping in the sterol 27-hydroxylase gene leads to cerebrotendinous xanthomatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Alternative splicing of CYP2D mRNA in human breast tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Two novel mutations in splice donor sites of CYP11B1 in congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

Allele-dropout using PCR-based diagnosis for the splicing mutation in intron-2 of the CYP21B-gene: successful amplification with a Taq/Pwo-polymerase mixture

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.2.3.399

21 January 2018

Identifiers

DOI

10.1517/17425255.2.3.399

1 reference

14 August 2017

1 reference