(Q36547723)

English

Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors.

scientific article published on January 2005

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869752%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

1 reference

Europe PubMed Central

Stem cell self-renewal and cancer cell proliferation are regulated by common networks that balance the activation of proto-oncogenes and tumor suppressors (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869752%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

stem cell self-renewal

1 reference

based on heuristic

inferred from title

1

1 reference

Europe PubMed Central

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27 December 2019

3

1 reference

Europe PubMed Central

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27 December 2019

Sean J. Morrison

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869752%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

author name string

A V Molofsky

2

1 reference

Europe PubMed Central

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27 December 2019

publication date

1 January 2005

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Europe PubMed Central

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27 December 2019

Cold Spring Harbor Symposia on Quantitative Biology

1 reference

Europe PubMed Central

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27 December 2019

70

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27 December 2019

177-185

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16869752%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Genetic regulation of primitive hematopoietic stem cell senescence

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The multiple roles of PTEN in tumor suppression

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p53: guardian AND suppressor of longevity?

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

"Super p53" mice exhibit enhanced DNA damage response, are tumor resistant and age normally

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in E mu-myc transgenic mice.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Mechanisms of cellular senescence in human and mouse cells.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Toward an understanding of the physiological function of Mammalian stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Lessons from hereditary colorectal cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Cancer-susceptibility genes. Gatekeepers and caretakers

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Wnt signaling and the regulation of stem cell function

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Ink4a/Arf expression is a biomarker of aging

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Essential role of mouse telomerase in highly proliferative organs

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Analysis of ku80-mutant mice and cells with deficient levels of p53

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Tumor suppression by Ink4a-Arf: progress and puzzles

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p53 sends nucleotides to repair DNA.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Modulation of mammalian life span by the short isoform of p53.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Telomeres and their control

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The p66shc adaptor protein controls oxidative stress response and life span in mammals

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Diverse mechanisms regulate stem cell self-renewal

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16Ink4a and p19Arf senescence pathways

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Regulatory mechanisms in stem cell biology

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Telomerase activity in hematopoietic cells is associated with self-renewal potential

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The aging of hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Applying the principles of stem-cell biology to cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Insulin-like growth factors and neoplasia.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Wnt signalling in stem cells and cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Stem cells, cancer, and cancer stem cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Gli and hedgehog in cancer: tumours, embryos and stem cells.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Ink4a/Arf links senescence and aging

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Telomeres, stem cells, senescence, and cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The INK4a/ARF network in tumour suppression

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The RB and p53 pathways in cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

ATM and related protein kinases: safeguarding genome integrity

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

PTENless means more.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The Hedgehog and Wnt signalling pathways in cancer

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The endocrine regulation of aging by insulin-like signals

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

p53 mutant mice that display early ageing-associated phenotypes

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Stem cells and cancer; the polycomb connection

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Variation in the human TP53 gene affects old age survival and cancer mortality.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Identification of cooperating oncogenes in E mu-myc transgenic mice by provirus tagging

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Deletion of Ku86 causes early onset of senescence in mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The bmi-1 oncoprotein is differentially expressed in non-small cell lung cancer and correlates with INK4A-ARF locus expression

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

The developmental biology of brain tumors.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Replicative senescence in normal liver, chronic hepatitis C, and hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

1 reference

https://api.crossref.org/works/10.1101%2FSQB.2005.70.057

21 January 2018

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