(Q36572626)

15 August 2017

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title

In vitro screening of drug metabolism during drug development: can we trust the predictions? (English)

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15 August 2017

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1

Olavi Pelkonen

1 reference

15 August 2017

Hannu Raunio

2

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15 August 2017

language of work or name

English

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publication date

1 June 2005

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Expert Opinion on Drug Metabolism & Toxicology

15 August 2017

published in

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15 August 2017

volume

1

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15 August 2017

issue

1

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15 August 2017

page(s)

49-59

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ADMET in silico modelling: towards prediction paradise?

15 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Drug metabolites in safety testing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Screening for the potential of a drug candidate to cause idiosyncratic drug reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Strategies for using in vitro screens in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Carbamazepine: a 'blind' assessment of CVP-associated metabolism and interactions in human liver-derived in vitro systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Validated assays for human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

LC/MS applications in drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Strategies for dealing with metabolite elucidation in drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Idiosyncratic toxicity: the role of toxicophores and bioactivation

21 January 2018

1 reference

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Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

In vitro tests for predicting drug-drug interactions: the need for validated procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

The 2002 Bernard B. Brodie Award lecture: deciphering substrate recognition by drug-metabolizing cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Progress in cytochrome P450 active site modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Structure-activity relationship for human cytochrome P450 substrates and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Generation and validation of rapid computational filters for cyp2d6 and cyp3a4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Quantitative structure-activity relationship analysis of inhibitors of the nicotine metabolizing CYP2A6 enzyme.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

A Human Drug Metabolism Database: Potential Roles in the Quantitative Predictions of Drug Metabolism and Metabolism-Related Drug-Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Early ADME in support of drug discovery: the role of metabolic stability studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

New hepatocyte in vitro systems for drug metabolism: metabolic capacity and recommendations for application in basic research and drug development, standard operation procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Metabolic stability for drug discovery and development: pharmacokinetic and biochemical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

Validation of Model of Cytochrome P450 2D6: An in Silico Tool for Predicting Metabolism and Inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425255.1.1.49

21 January 2018

Identifiers

DOI

10.1517/17425255.1.1.49

1 reference

release_ufj7m2m44zflzkpzsu3c3qqc5u

15 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ufj7m2m44zflzkpzsu3c3qqc5u

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference