(Q36709988)

English

The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors

scientific article published on 16 January 2007

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scholarly article

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

The genetic engineering of hematopoietic stem cells: the rise of lentiviral vectors, the conundrum of the ltr, and the promise of lineage-restricted vectors (English)

1 reference

Europe PubMed Central

15 August 2017

author name string

Alex H Chang

1

1 reference

Europe PubMed Central

15 August 2017

Michel Sadelain

2

1 reference

Europe PubMed Central

15 August 2017

publication date

16 January 2007

1 reference

Europe PubMed Central

15 August 2017

Molecular Therapy

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Europe PubMed Central

15 August 2017

15

1 reference

Europe PubMed Central

15 August 2017

445-456

1 reference

Europe PubMed Central

15 August 2017

3

1 reference

Europe PubMed Central

15 August 2017

Gene transfer to hematopoietic stem cells: implications for gene therapy of human disease.

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Site-specific genomic integration produces therapeutic Factor IX levels in mice

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Awakening gene therapy with Sleeping Beauty transposons

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Highly efficient endogenous human gene correction using designed zinc-finger nucleases

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RETRACTED: Complete and persistent phenotypic correction of phenylketonuria in mice by site-specific genome integration of murine phenylalanine hydroxylase cDNA.

1 reference

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American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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HIV, but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic stem cells

1 reference

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Transduction of human CD34+ cells that mediate long-term engraftment of NOD/SCID mice by HIV vectors

1 reference

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Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors

1 reference

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Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin

1 reference

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Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors

1 reference

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7 January 2021

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Foamy virus vector integration sites in normal human cells

1 reference

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7 January 2021

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inferred from DOI database lookup

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy

1 reference

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based on heuristic

inferred from DOI database lookup

Hematopoietic stem cells engraft in mice with absolute efficiency

1 reference

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7 January 2021

based on heuristic

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The relative quiescence of hematopoietic stem cells in nonhuman primates

1 reference

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7 January 2021

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In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

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Behavior of hematopoietic stem cells in a large animal

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Telomere fluorescence measurements in granulocytes and T lymphocyte subsets point to a high turnover of hematopoietic stem cells and memory T cells in early childhood.

1 reference

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7 January 2021

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Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1 reference

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7 January 2021

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Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

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HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Viral protein R regulates docking of the HIV-1 preintegration complex to the nuclear pore complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

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Intracellular trafficking of retroviral genomes during the early phase of infection: viral exploitation of cellular pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

HIV-1 genome nuclear import is mediated by a central DNA flap

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The cell cycle independence of HIV infections is not determined by known karyophilic viral elements

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Human cord blood CD34+CD38- cell transduction via lentivirus-based gene transfer vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Transduction of Human CD34+CD38- Bone Marrow and Cord Blood-Derived SCID-Repopulating Cells with Third-Generation Lentiviral Vectors

1 reference

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based on heuristic

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Nonproductive human immunodeficiency virus type 1 infection in nucleoside-treated G0 lymphocytes

1 reference

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based on heuristic

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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

1 reference

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based on heuristic

inferred from DOI database lookup

Incompletely reverse-transcribed human immunodeficiency virus type 1 genomes in quiescent cells can function as intermediates in the retroviral life cycle

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Reduction in levels of the cyclin-dependent kinase inhibitor p27(kip-1) coupled with transforming growth factor beta neutralization induces cell-cycle entry and increases retroviral transduction of primitive human hematopoietic cells

1 reference

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based on heuristic

inferred from DOI database lookup

Hematopoietic stem cell quiescence maintained by p21cip1/waf1

1 reference

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based on heuristic

inferred from DOI database lookup

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

The fluctuating phenotype of the lymphohematopoietic stem cell with cell cycle transit

1 reference

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based on heuristic

inferred from DOI database lookup

Impaired bone marrow homing of cytokine-activated CD34+ cells in the NOD/SCID model.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of chronic cytokine therapy on clonal dynamics in nonhuman primates.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Hematopoietic stem cell gene therapy: dead or alive?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with stem cell factor and granulocyte colony-stimulating factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral transduction efficiency of G-CSF+SCF-mobilized peripheral blood CD34+ cells is superior to G-CSF or G-CSF+Flt3-L-mobilized cells in nonhuman primates.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Innovative strategies for PBPC mobilization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure-function based design of small molecule inhibitors targeting Rho family GTPases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Lentivector-mediated clonal tracking reveals intrinsic heterogeneity in the human hematopoietic stem cell compartment and culture-induced stem cell impairment

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytokines: value-added products in hematopoietic stem cell gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus-based lentiviral vector system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficiency of transduction of highly purified murine hematopoietic stem cells by lentiviral and oncoretroviral vectors under conditions of minimal in vitro manipulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional assessment of the engraftment potential of gammaretrovirus-modified CD34+ cells, using a short serum-free transduction protocol

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Highly efficient lentiviral gene transfer in CD34+ and CD34+/38-/lin- cells from mobilized peripheral blood after cytokine prestimulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Factors influencing the titer and infectivity of lentiviral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Advances in lentiviral vector design for gene-modification of hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Proteasome activity restricts lentiviral gene transfer into hematopoietic stem cells and is down-regulated by cytokines that enhance transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Stimulation of mouse bone marrow cells with kit ligand, FLT3 ligand, and thrombopoietin leads to efficient retrovirus-mediated gene transfer to stem cells, whereas interleukin 3 and interleukin 11 reduce transduction of short- and long-term repopula

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Converging pathways in leukemogenesis and stem cell self-renewal

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel lentiviral vectors displaying "early-acting cytokines" selectively promote survival and transduction of NOD/SCID repopulating human hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Antiviral activity of the proteasome on incoming human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus cDNA metabolism: notable stability of two-long terminal repeat circles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retrovirus restriction factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Intrinsic immunity: a front-line defense against viral attack

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Modulation of hematopoietic stem cell homing and engraftment by CD26

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of CD26 peptidase activity significantly improves engraftment of retrovirally transduced hematopoietic progenitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Critical factors influencing stable transduction of human CD34(+) cells with HIV-1-derived lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The presence of the carboxy-terminal fragment of fibronectin allows maintenance of non-human primate long-term hematopoietic repopulating cells during extended ex vivo culture and transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of busulfan dose escalation on engraftment of infant rhesus monkey hematopoietic stem cells after gene marking by a lentiviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Transcription start regions in the human genome are favored targets for MLV integration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retrovirus vectors: toward the plentivirus?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Insertion of retroviral vectors in NOD/SCID repopulating human peripheral blood progenitor cells occurs preferentially in the vicinity of transcription start regions and in introns

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Occurrence of leukaemia following gene therapy of X-linked SCID.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Promoter trapping reveals significant differences in integration site selection between MLV and HIV vectors in primary hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Genotoxicity of retroviral integration in hematopoietic cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Murine leukemia induced by retroviral gene marking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

EVI1 and hematopoietic disorders: history and perspectives

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Side effects of retroviral gene transfer into hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

New genes involved in cancer identified by retroviral tagging

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral insertional mutagenesis: past, present and future

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retroviral expression in embryonic stem cells and hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

eGFP reporter genes silence LCRbeta-globin transgene expression via CpG dinucleotides

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Lentiviral vectors for enhanced gene expression in human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

High-level transduction and gene expression in hematopoietic repopulating cells using a human immunodeficiency [correction of imunodeficiency] virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Lentivirus gene transfer in murine hematopoietic progenitor cells is compromised by a delay in proviral integration and results in transduction mosaicism and heterogeneous gene expression in progeny cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced transgene expression in cord blood CD34(+)-derived hematopoietic cells, including developing T cells and NOD/SCID mouse repopulating cells, following transduction with modified trip lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic induction of immune tolerance to human clotting factor VIII in a mouse model for hemophilia A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained phenotypic correction of hemophilia a mice following oncoretroviral-mediated expression of a bioengineered human factor VIII gene in long-term hematopoietic repopulating cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient production of human FVIII in hemophilic mice using lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Recombinant factor VIII expression in hematopoietic cells following lentiviral transduction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Sustained transgene expression by human cord blood derived CD34+ cells transduced with simian immunodeficiency virus agmTYO1-based vectors carrying the human coagulation factor VIII gene in NOD/SCID mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell-derived erythroid cells mediate long-term systemic protein delivery

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Silencing and variegation of gammaretrovirus and lentivirus vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Virus infection of murine teratocarcinoma stem cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Silent infection of murine embryonal carcinoma cells by Moloney murine leukemia virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic manipulation of primate embryonic and hematopoietic stem cells with simian lentivirus vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of CpGs in the murine stem cell virus retroviral vector long terminal repeat represses silencing in embryonic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retrovirus silencing, variegation, extinction, and memory are controlled by a dynamic interplay of multiple epigenetic modifications

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenesis by lentiviral vectors: lack of gene silencing in mammalian embryonic stem cells and preimplantation embryos

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Generation of transgenic mice using lentiviral vectors: a novel preclinical assessment of lentiviral vectors for gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of gene therapy for hematopoietic stem cells using lentiviral vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Lentivirus vector gene expression during ES cell-derived hematopoietic development in vitro

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Equal potency of gammaretroviral and lentiviral SIN vectors for expression of O6-methylguanine-DNA methyltransferase in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

A third-generation lentivirus vector with a conditional packaging system

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatitis B virus RNA element that facilitates accumulation of surface gene transcripts in the cytoplasm.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Context Dependence of Different Modules for Posttranscriptional Enhancement of Gene Expression from Retroviral Vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE).

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Stem cell gene therapy for the beta-chain hemoglobinopathies. Problems and progress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy progress and prospects: development of improved lentiviral and retroviral vectors--design, biosafety, and production.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Insulators: many functions, many mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Position-effect protection and enhancer blocking by the chicken beta-globin insulator are separable activities

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Recruitment of histone modifications by USF proteins at a vertebrate barrier element

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

A chromatin insulator protects retrovirus vectors from chromosomal position effects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Topological constraints governing the use of the chicken HS4 chromatin insulator in oncoretrovirus vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Performance- and safety-enhanced lentiviral vectors containing the human interferon-beta scaffold attachment region and the chicken beta-globin insulator

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Biological significance of unwinding capability of nuclear matrix-associating DNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Human matrix attachment regions insulate transgene expression from chromosomal position effects in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Scaffold attachment region-containing retrovirus vectors improve long-term proviral expression after transplantation of GFP-modified CD34+ baboon repopulating cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Hematopoietic stem cell gene therapy with drug resistance genes: an update

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Survival of the fittest: in vivo selection and stem cell gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy with drug resistance genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Hematoprotection and enrichment of transduced cells in vivo after gene transfer of MGMT(P140K) into hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo selection of MGMT(P140K) lentivirus–transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Repopulating defect of mismatch repair–deficient hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Locus control regions: coming of age at a decade plus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Locus control regions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

ChIPs of the beta-globin locus: unraveling gene regulation within an active domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Locus control regions of mammalian beta-globin gene clusters: combining phylogenetic analyses and experimental results to gain functional insights

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Position-independent, high-level expression of the human beta-globin gene in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The beta-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Successful treatment of murine beta-thalassemia intermedia by transfer of the human beta-globin gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Correction of sickle cell disease in transgenic mouse models by gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Permanent and panerythroid correction of murine beta thalassemia by multiple lentiviral integration in hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

The degree of phenotypic correction of murine beta -thalassemia intermedia following lentiviral-mediated transfer of a human gamma-globin gene is influenced by chromosomal position effects and vector copy number

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel murine model of Cooley anemia and its rescue by lentiviral-mediated human beta-globin gene transfer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Correction of a mouse model of sickle cell disease: lentiviral/antisickling beta-globin gene transduction of unmobilized, purified hematopoietic stem cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Extended beta-globin locus control region elements promote consistent therapeutic expression of a gamma-globin lentiviral vector in murine beta-thalassemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Locus control region of the human CD2 gene in a lentivirus vector confers position-independent transgene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Specific transgene expression in human and mouse CD4+ cells using lentiviral vectors with regulatory sequences from the CD4 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy of apolipoprotein E-deficient mice using a novel macrophage-specific retroviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting transgene expression to antigen-presenting cells derived from lentivirus-transduced engrafting human hematopoietic stem/progenitor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA-triggered gene silencing

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

RNA interference in adult mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Therapeutic applications of RNA interference: recent advances in siRNA design

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy progress and prospects: recent progress in transgene and RNAi expression cassettes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of the interferon system by short-interfering RNAs

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Determinants of interferon-stimulated gene induction by RNAi vectors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

A genetic strategy to treat sickle cell anemia by coregulating globin transgene expression and RNA interference

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene transfer in humans using a conditionally replicating lentiviral vector

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

No soluble common cytokine receptor gamma chain (gamma(c)) in activated human lymphocyte cultures-comparison with soluble IL-2Ralpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Biochemical and Functional Abnormalities in Lymphocytes from an Adenosine Deaminase-deficient Patient during Enzyme Replacement Therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Immune reconstitution in ADA-SCID after PBL gene therapy and discontinuation of enzyme replacement

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficacy of gene therapy for Wiskott-Aldrich syndrome using a WAS promoter/cDNA-containing lentiviral vector and nonlethal irradiation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Correction of murine hemophilia A by hematopoietic stem cell gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MT.6300060

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.MT.6300060

1 reference

Europe PubMed Central

15 August 2017

1 reference

Europe PubMed Central

15 August 2017

ResearchGate publication ID

0 references

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