(Q36845653)

16 August 2017

1 reference

title

Discovery of activation-induced cytidine deaminase, the engraver of antibody memory (English)

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16 August 2017

1 reference

5

Tasuku Honjo

1 reference

16 August 2017

1

Masamichi Muramatsu

1 reference

16 August 2017

Hitoshi Nagaoka

2

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16 August 2017

Reiko Shinkura

series ordinal

3

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16 August 2017

Nasim A Begum

series ordinal

4

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16 August 2017

publication date

1 January 2007

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16 August 2017

published in

Advances in Immunology

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16 August 2017

volume

94

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16 August 2017

page(s)

1-36

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Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

16 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

CD40 ligand gene defects responsible for X-linked hyper-IgM syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Increased transcription levels induce higher mutation rates in a hypermutating cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Diversity of HIV-1 Vpr interactions involves usage of the WXXF motif of host cell proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

DNA double-strand breaks: prior to but not sufficient in targeting hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Ku80 is required for immunoglobulin isotype switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Vpr-mediated incorporation of UNG2 into HIV-1 particles is required to modulate the virus mutation rate and for replication in macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The apolipoprotein B mRNA editing complex performs a multifunctional cycle and suppresses nonsense-mediated decay

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID-mediated deoxycytidine deamination.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID mediates hypermutation by deaminating single stranded DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Internal IgH class switch region deletions are position-independent and enhanced by AID expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X-linked hyper IgM syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID-dependent somatic hypermutation occurs as a DNA single-strand event in the BL2 cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Non-redundancy of cytidine deaminases in class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic hypermutation in the heavy chain locus correlates with transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Role of CD40-CD40-ligand interaction in Ig-isotype switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Molecular mechanism of class switch recombination: linkage with somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID to overcome the limitations of genomic information

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Physical and functional interaction of human nuclear uracil-DNA glycosylase with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

MDM2 can interact with the C-terminus of AID but it is inessential for antibody diversification in DT40 B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Ku70 is required for late B cell development and immunoglobulin heavy chain class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The interaction of vpr with uracil DNA glycosylase modulates the human immunodeficiency virus type 1 In vivo mutation rate

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic hypermutation of the AID transgene in B and non-B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Affinity maturation without germinal centres in lymphotoxin-alpha-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32 kDa subunit of human replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The transcriptional programme of antibody class switching involves the repressor Bach2.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (AID) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced deaminase (AID)-directed hypermutation in the immunoglobulin Smu region: implication of AID involvement in a common step of class switch recombination and somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

A sequence in the N-terminal region of human uracil-DNA glycosylase with homology to XPA interacts with the C-terminal part of the 34-kDa subunit of replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

High frequency class switching of an IgM+ B lymphoma clone CH12F3 to IgA+ cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Transcription-coupled events associating with immunoglobulin switch region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Escherichia coli cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Immunity through DNA deamination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Histone modifications associated with somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The AID enzyme induces class switch recombination in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Constitutive expression of AID leads to tumorigenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Post-replicative base excision repair in replication foci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Structure and function in the uracil-DNA glycosylase superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

HIV-1-associated uracil DNA glycosylase activity controls dUTP misincorporation in viral DNA and is essential to the HIV-1 life cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID is required for c-myc/IgH chromosome translocations in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Inducible DNA breaks in Ig S regions are dependent on AID and UNG

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Separate domains of AID are required for somatic hypermutation and class-switch recombination

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Immunoglobulin class switching

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Depletion of uracil-DNA glycosylase activity is associated with decreased cell proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID mutant analyses indicate requirement for class-switch-specific cofactors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Molecular cloning of an apolipoprotein B messenger RNA editing protein

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Somatic generation of antibody diversity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Identification of a specific domain required for dimerization of activation-induced cytidine deaminase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Induction of somatic hypermutation is associated with modifications in immunoglobulin variable region chromatin

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

The double-edged sword of activation-induced cytidine deaminase.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

Demonstration of M cells in the specialized follicle-associated epithelium overlying isolated lymphoid follicles in the gut.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2776%2806%2994001-2

7 January 2021

10.1016/S0065-2776(06)94001-2

Identifiers

DOI

1 reference

16 August 2017

1 reference