(Q37008257)

17 August 2017

1 reference

title

What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain (English)

1 reference

17 August 2017

Hamsa Puthalakath

2

0 references

Philippe Bouillet

object named as

Philippe Bouillet

series ordinal

4

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Andreas Strasser

object named as

Andreas Strasser

series ordinal

1

0 references

Lorraine A O'Reilly

series ordinal

3

object named as

Lorraine A O'Reilly

1 reference

17 August 2017

publication date

20 November 2007

1 reference

Immunology & Cell Biology

17 August 2017

published in

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17 August 2017

volume

86

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17 August 2017

issue

1

1 reference

17 August 2017

page(s)

57-66

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Cellular and genetic mechanisms of self tolerance and autoimmunity

17 August 2017

cites work

1 reference

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21 January 2018

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The role of BH3-only proteins in the immune system

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Multistep pathogenesis of autoimmune disease.

21 January 2018

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The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

21 January 2018

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Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

21 January 2018

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Peripheral deletion of self-reactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Clonal deletion of immature CD4+8+ thymocytes in suspension culture by extrathymic antigen-presenting cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas

21 January 2018

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Mechanisms and Functions of Cell Death

21 January 2018

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21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

21 January 2018

Caspases: enemies within

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https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Caspase-8 serves both apoptotic and nonapoptotic roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Ionizing radiation and chemotherapeutic drugs induce apoptosis in lymphocytes in the absence of Fas or FADD/MORT1 signaling. Implications for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The pathophysiology of mitochondrial cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Specific ablation of the apoptotic functions of cytochrome C reveals a differential requirement for cytochrome C and Apaf-1 in apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Testicular degeneration in Bclw-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apoptosis regulator bcl-w is essential for spermatogenesis but appears otherwise redundant

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The Bcl-2 apoptotic switch in cancer development and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BH3-Only proteins-essential initiators of apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Proapoptotic Bcl-2 family member Bim is involved in the control of mast cell survival and is induced together with Bcl-XL upon IgE-receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

ER stress triggers apoptosis by activating BH3-only protein Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

p53 is required for radiation-induced apoptosis in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Thymocyte apoptosis induced by p53-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bad-deficient mice develop diffuse large B cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Hrk/DP5 contributes to the apoptosis of select neuronal populations but is dispensable for haematopoietic cell apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Receptor-stimulated death pathway is opened by antigen in mature T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Fas ligand mediates activation-induced cell death in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

T-lymphocyte death during shutdown of an immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Cytokine-induced survival of activated T cells in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Antigen-induced B-cell death and elimination during germinal-centre immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Involvement of Bik, a proapoptotic member of the Bcl-2 family, in surface IgM-mediated B cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Gene expression analysis of thymocyte selection in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Thymocyte negative selection is mediated by protein kinase C- and Ca2+-dependent transcriptional induction of bim [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apoptosis during negative selection of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Nur77 transcription activity correlates with its apoptotic function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Extracellular signal-regulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

ERK1/2-dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl-1 and Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Deletion of self-reactive T cells before entry into the thymus medulla

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Induction of self-tolerance in mature peripheral B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

The primary equilibrium between antigen and antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

In vivo calcium elevations in thymocytes with T cell receptors that are specific for self ligands

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

The need for central and peripheral tolerance in the B cell repertoire

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Transcriptional analysis of clonal deletion in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Regulation of Bim by TCR signals in CD4/CD8 double-positive thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ICB.7100141

7 January 2021

Identifiers

DOI

10.1038/SJ.ICB.7100141

1 reference

Dimensions Publication ID

17 August 2017

1031504089

0 references

1 reference