(Q37018652)

17 August 2017

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title

Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors (English)

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17 August 2017

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Robert C Castellino

1

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17 August 2017

Donald L Durden

series ordinal

2

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17 August 2017

publication date

1 December 2007

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Nature Clinical Practice Neurology

17 August 2017

published in

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17 August 2017

volume

3

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17 August 2017

issue

12

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17 August 2017

page(s)

682-693

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https://scigraph.springernature.com/pub.10.1038/ncpneuro0661

17 August 2017

exact match

0 references

cites work

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis

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Current epidemiological trends and surveillance issues in brain tumors

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A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival

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7 January 2021

Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents

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7 January 2021

State-of-the-art treatment of high-grade brain tumors

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7 January 2021

Current management of glioblastoma multiforme

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7 January 2021

Clinical presentation, diagnosis, and pharmacotherapy of patients with primary brain tumors

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7 January 2021

Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults.

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7 January 2021

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

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7 January 2021

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7 January 2021

The microenvironment of the tumour-host interface

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7 January 2021

Friends or foes - bipolar effects of the tumour stroma in cancer

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7 January 2021

Transplacental carcinogenesis by stilbestrol

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7 January 2021

Anti-angiogenesis: new concept for therapy of solid tumors

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Duodenal ulcer. Discovery of a new mechanism and development of angiogenic therapy that accelerates healing

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Distinct transcription profiles of primary and secondary glioblastoma subgroups.

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7 January 2021

Endogenous inhibitors of angiogenesis in malignant gliomas: nature's antiangiogenic therapy

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7 January 2021

Immunolocalization of basic fibroblast growth factor to the microvasculature of human brain tumors

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7 January 2021

Angiogenesis in malignant gliomas

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7 January 2021

Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2.

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7 January 2021

Microvessel density is a prognostic indicator for patients with astroglial brain tumors.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

The phosphoinositide 3-kinase pathway

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PIK3CA alterations in primary (de novo) and secondary glioblastomas.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

High frequency of mutations of the PIK3CA gene in human cancers

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7 January 2021

PIK3CA gene mutations in pediatric and adult glioblastoma multiforme.

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7 January 2021

Lessons learned in the development of targeted therapy for malignant gliomas.

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7 January 2021

Role of integrins in cell invasion and migration

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7 January 2021

The FN13 peptide inhibits human tumor cells invasion through the modulation of alpha v beta 3 integrins organization and the inactivation of ILK pathway

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Integrin-linked kinase (ILK) regulation of the cell viability in PTEN mutant glioblastoma and in vitro inhibition by the specific COX-2 inhibitor NS-398.

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma

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https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PKB binding proteins. Getting in on the Akt.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Identification of a tumour suppressor network opposing nuclear Akt function

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Microvascular patterning is controlled by fine-tuning the Akt signal

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Regulation of angiogenesis by hypoxia-inducible factor 1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Intratumoral hypoxia, radiation resistance, and HIF-1.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Akt1 activation can augment hypoxia-inducible factor-1alpha expression by increasing protein translation through a mammalian target of rapamycin-independent pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

On the Origin of Cancer Cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Mitochondrial tumour suppressors: a genetic and biochemical update

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Akt stimulates aerobic glycolysis in cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Cancer's molecular sweet tooth and the Warburg effect.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Metabolic catastrophe as a means to cancer cell death

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Lysosomes in cell death

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Multiple cell death pathways as regulators of tumour initiation and progression.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Lysosomes and autophagy in cell death control

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Progress report on the potential of angiogenesis inhibitors for neuro-oncology

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Targeting tyrosine kinases in cancer: the second wave

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

The BCR-ABL story: bench to bedside and back

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCPNEURO0661

7 January 2021

Identifiers

DOI

10.1038/NCPNEURO0661

1 reference

Dimensions Publication ID

17 August 2017

1026269888

0 references

1 reference