(Q37546115)

20 August 2017

1 reference

title

Novel inhibitors of the PI3K family (English)

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20 August 2017

Amancio Carnero

1

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language of work or name

English

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publication date

1 September 2009

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Expert Opinion on Investigational Drugs

20 August 2017

published in

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20 August 2017

volume

18

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20 August 2017

issue

9

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20 August 2017

page(s)

1265-1277

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

20 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The PTEN/PI3K/AKT signalling pathway in cancer, therapeutic implications

21 January 2018

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Signalling by PI3K isoforms: insights from gene-targeted mice.

21 January 2018

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways

21 January 2018

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Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

21 January 2018

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Interaction of phosphatidylinositol 3-kinase-associated p85 with epidermal growth factor and platelet-derived growth factor receptors

21 January 2018

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Ras activation of phosphatidylinositol 3-kinase and Akt.

21 January 2018

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

21 January 2018

Phosphoinositide kinases

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The regulation and function of Class III PI3Ks: novel roles for Vps34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The phosphoinositide 3-kinase pathway

21 January 2018

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21 January 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

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High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543780903066798

Class I PI3K in oncogenic cellular transformation.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543780903066798

Rare cancer-specific mutations in PIK3CA show gain of function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Functional analysis of PIK3CA gene mutations in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Expression of a mutated form of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase in a Hodgkin's lymphoma-derived cell line (CO).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Cancer-specific mutations in PIK3CA are oncogenic in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Genetic alterations of phosphoinositide 3-kinase subunit genes in human glioblastomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PTEN, more than the AKT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Colorectal cancer: mutations in a signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Clinical and pathological features of breast disease in Cowden's syndrome: an underrecognized syndrome with an increased risk of breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Human cancer, PTEN and the PI-3 kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Deregulated Akt3 activity promotes development of malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PI3K pathway alterations in cancer: variations on a theme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Exploring the specificity of the PI3K family inhibitor LY294002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Wortmannin, an inhibitor of phosphatidyl-inositol 3-kinase, induces oocyte maturation through a MPF-MAPK-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Phosphoinositide 3-kinase inhibition in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Blocking the PI3K/PKB pathway in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Pegylated wortmannin and 17-hydroxywortmannin conjugates as phosphoinositide 3-kinase inhibitors active in human tumor xenograft models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Drug discovery approaches targeting the PI3K/Akt pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Phosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Antitumor activity of ZSTK474, a new phosphatidylinositol 3-kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PI3K/AKT signaling and systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Cardiac regulation by phosphoinositide 3-kinases and PTEN

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Targeted inhibition of phosphoinositide 3-kinase activity as a novel strategy to normalize beta-adrenergic receptor function in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Intracellular signalling. Key enzyme in leptin-induced anorexia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Chemically targeting the PI3K family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

21 January 2018

The two TORCs and Akt.

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The life and death of DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Role of DNA-PK in the cellular response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Targeting RAS signalling pathways in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non-small cell lung cancer xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

Amplification of 19q13.1–q13.2 sequences in ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543780903066798

10.1517/13543780903066798

21 January 2018

Identifiers

DOI

1 reference

release_v4p7r647evbrlghmzjwy2eirri

20 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/v4p7r647evbrlghmzjwy2eirri

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference