(Q37635281)

21 August 2017

1 reference

title

TGF-β1 pathway as a new target for neuroprotection in Alzheimer's disease (English)

1 reference

21 August 2017

0 references

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Filippo Caraci

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Giuseppe Battaglia

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

Valeria Maria Gloria Bruno

14 May 2020

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Maria Laura Giuffrida

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Ferdinando Nicoletti

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

8

Maria Angela Sortino

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

author name string

Paolo Bosco

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Viviana Carbonaro

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

Agata Copani

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

publication date

19 November 2009

1 reference

CNS Neuroscience & Therapeutics

21 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

volume

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

page(s)

237-249

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death

14 May 2020

cites work

1 reference

12 December 2020

Mitotic signaling by beta-amyloid causes neuronal death

1 reference

12 December 2020

Eukaryotic DNA polymerases, a growing family

1 reference

12 December 2020

Co-activation of TGF-ss and cytokine signaling pathways are required for neurotrophic functions

1 reference

12 December 2020

Inflamm-aging. An evolutionary perspective on immunosenescence

1 reference

12 December 2020

Cytokine gene expression as a function of the clinical progression of Alzheimer disease dementia.

1 reference

12 December 2020

Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease

1 reference

12 December 2020

Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts

1 reference

12 December 2020

Anti-inflammatory drugs protect against Alzheimer disease at low doses.

1 reference

12 December 2020

TGF-beta1 inhibits caspase-3 activation and neuronal apoptosis in rat hippocampal cultures

1 reference

12 December 2020

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

12 December 2020

DNA replication precedes neuronal cell death in Alzheimer's disease.

1 reference

12 December 2020

TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

1 reference

12 December 2020

Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.

1 reference

12 December 2020

Hippocampal injections of amyloid beta-peptide 1-40 impair subsequent one-trial/day reward learning.

1 reference

12 December 2020

Transgenic mouse models of Alzheimer's disease

1 reference

12 December 2020

Transforming growth factor-beta1 enhances expression of brain-derived neurotrophic factor and its receptor, TrkB, in neurons cultured from rat cerebral cortex

1 reference

12 December 2020

Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia

1 reference

12 December 2020

Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain

1 reference

12 December 2020

Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage.

1 reference

12 December 2020

Increased transforming growth factor-beta(1) circulating levels and production in human monocytes after 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase inhibition with pravastatin

1 reference

12 December 2020

SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

1 reference

12 December 2020

Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads.

1 reference

12 December 2020

Depolarization drives beta-Catenin into neuronal spines promoting changes in synaptic structure and function

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Genetic variability in the insulin signalling pathway may contribute to the risk of late onset Alzheimer's disease.

1 reference

12 December 2020

Astrocytes are less efficient in the removal of apoptotic lymphocytes than microglia cells: implications for the role of glial cells in the inflamed central nervous system

1 reference

12 December 2020

Erratic expression of DNA polymerases by beta-amyloid causes neuronal death.

1 reference

12 December 2020

Glatiramer acetate: a review of its use in relapsing-remitting multiple sclerosis

1 reference

12 December 2020

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

1 reference

12 December 2020

Making sense of latent TGFbeta activation

1 reference

12 December 2020

Acetylsalicylic acid inhibits cell proliferation by involving transforming growth factor-beta

1 reference

12 December 2020

TGF-betas and their roles in the regulation of neuron survival

1 reference

12 December 2020

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice.

1 reference

12 December 2020

Plasma cytokine profiles in elderly humans

1 reference

12 December 2020

Small molecule Trk receptor agonists and other neurotrophic factor mimetics

1 reference

12 December 2020

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

1 reference

12 December 2020

Does aspirin protect against Alzheimer's dementia? A study in a Swedish population-based sample aged > or =80 years

1 reference

12 December 2020

Astrocyte protection of neurons: role of transforming growth factor-beta signaling via a c-Jun-AP-1 protective pathway

1 reference

12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1 reference

12 December 2020

Phagocytosis and deposition of vascular beta-amyloid in rat brains injected with Alzheimer beta-amyloid

1 reference

12 December 2020

β-catenin is critical for dendritic morphogenesis

1 reference

12 December 2020

Smad-dependent and Smad-independent pathways in TGF-beta family signalling

1 reference

12 December 2020

Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain.

1 reference

12 December 2020

Neuroprotection by transforming growth factor-beta1 involves activation of nuclear factor-kappaB through phosphatidylinositol-3-OH kinase/Akt and mitogen-activated protein kinase-extracellular-signal regulated kinase1,2 signaling pathways.

1 reference

12 December 2020

To die or not to die: how does p53 decide?

1 reference

12 December 2020

New insights into TGF-beta-Smad signalling

1 reference

12 December 2020

Impact of estrogen therapy on Alzheimer's disease: a fork in the road?

1 reference

12 December 2020

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

1 reference

12 December 2020

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

1 reference

12 December 2020

Glia mediates the neuroprotective action of estradiol on beta-amyloid-induced neuronal death.

1 reference

12 December 2020

Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort study.

1 reference

12 December 2020

Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications

1 reference

12 December 2020

Divide and die: cell cycle events as triggers of nerve cell death.

1 reference

12 December 2020

Increased plasma levels of soluble CD40, together with the decrease of TGF beta 1, as possible differential markers of Alzheimer disease.

1 reference

12 December 2020

The G/C915 polymorphism of transforming growth factor beta1 is associated with human longevity: a study in Italian centenarians

1 reference

12 December 2020

Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease

1 reference

12 December 2020

The amyloid-beta peptide suppresses transforming growth factor-beta1-induced matrix metalloproteinase-2 production via Smad7 expression in human monocytic THP-1 cells.

1 reference

12 December 2020

Atypical antipsychotic drugs and risk of ischaemic stroke: population based retrospective cohort study

1 reference

12 December 2020

Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers

1 reference

12 December 2020

TGF-{beta}1 activates two distinct type I receptors in neurons: implications for neuronal NF-{kappa}B signaling

1 reference

12 December 2020

Reduced brain tissue perfusion in TGF-beta 1 transgenic mice showing Alzheimer's disease-like cerebrovascular abnormalities

1 reference

12 December 2020

A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease

1 reference

12 December 2020

Small molecule tgf-beta mimetics as potential neuroprotective factors

1 reference

12 December 2020

Th1, Th2, and Th3 cytokine alterations in major depression.

1 reference

12 December 2020

The role of neurotrophins in brain aging: a perspective in honor of Regino Perez-Polo

1 reference

12 December 2020

Transforming growth factor-beta signalling in brain disorders

1 reference

12 December 2020

Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases

1 reference

12 December 2020

The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice

1 reference

12 December 2020

TGFbeta1 regulates the inflammatory response during chronic neurodegeneration

1 reference

12 December 2020

Transforming growth factor-beta regulation of immune responses

1 reference

12 December 2020

Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis

1 reference

12 December 2020

The role of IL-12 and TGF-beta1 in the pathophysiology of major depressive disorder

1 reference

12 December 2020

Neurotrophins and dementia--keeping in touch

1 reference

12 December 2020

Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the anti-depressant tianeptine.

1 reference

12 December 2020

Alzheimer disease: progress or profit?

1 reference

12 December 2020

Tgf-Beta pathway as a potential target in neurodegeneration and Alzheimer's

1 reference

12 December 2020

Dose and temporal pattern of estrogen exposure determines neuroprotective outcome in hippocampal neurons: therapeutic implications

1 reference

12 December 2020

Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?

1 reference

12 December 2020

Therapeutic approaches to Alzheimer's disease

1 reference

12 December 2020

DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

1 reference

12 December 2020

Altered subcellular location of phosphorylated Smads in Alzheimer's disease.

1 reference

12 December 2020

Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology

1 reference

12 December 2020

GDNF applied to the MPTP-lesioned nigrostriatal system requires TGF-beta for its neuroprotective action

1 reference

12 December 2020

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death.

1 reference

12 December 2020

Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity

1 reference

12 December 2020

Neurofibrillary tangles may interfere with Smad 2/3 signaling in neurons.

1 reference

12 December 2020

Effects of atorvastatin and aspirin combined therapy on inflammatory responses in patients undergoing coronary artery bypass grafting

1 reference

12 December 2020

Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice

1 reference

12 December 2020

Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder

1 reference

12 December 2020

Venlafaxine exhibits an anti-inflammatory effect in an inflammatory co-culture model

1 reference

12 December 2020

TGF-beta1: a novel target for cardiovascular pharmacology

1 reference

12 December 2020

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

1 reference

12 December 2020

Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease

1 reference

12 December 2020

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

1 reference

12 December 2020

+10 T/C polymorphisms in the gene of transforming growth factor-β1 are associated with neurodegeneration and its clinical evolution

1 reference

12 December 2020

Reduced insulin-induced phosphatidylinositol-3-kinase activation in peripheral blood mononuclear leucocytes from patients with Alzheimer's disease.

1 reference

12 December 2020

Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling

1 reference

12 December 2020

The biology of neurotrophins, signalling pathways, and functional peptide mimetics of neurotrophins and their receptors

1 reference

12 December 2020

Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy

1 reference

12 December 2020

TGF-beta1 targets the GSK-3beta/beta-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts.

1 reference

12 December 2020

TGF-beta 1 protects against Abeta-neurotoxicity via the phosphatidylinositol-3-kinase pathway.

1 reference

12 December 2020

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

1 reference

12 December 2020

Reduced risk of incident AD with elective statin use in a clinical trial cohort

1 reference

12 December 2020

Lithium may be useful in the prevention of Alzheimer's disease in individuals at risk of presenile familial Alzheimer's disease

1 reference

12 December 2020

Neuropsychiatric symptoms in dementia: importance and treatment considerations.

1 reference

12 December 2020

Microglial activation and amyloid deposition in mild cognitive impairment: a PET study

1 reference

12 December 2020

Antidepressants and dementia

1 reference

12 December 2020

Why do centenarians escape or postpone cancer? The role of IGF-1, inflammation and p53.

1 reference

12 December 2020

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

1 reference

12 December 2020

The role of neuroimmunomodulation in Alzheimer's disease.

1 reference

12 December 2020

Normal embryo fibroblasts release transforming growth factors in a latent form

1 reference

12 December 2020

The serum concentration of active transforming growth factor-beta is severely depressed in advanced atherosclerosis

1 reference

12 December 2020

Processing of transforming growth factor beta 1 precursor by human furin convertase

1 reference

12 December 2020

Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide

1 reference

12 December 2020

TGF-beta 1 is an organizer of responses to neurodegeneration

1 reference

12 December 2020

Serum cytokine levels in patients with Alzheimer's disease

1 reference

12 December 2020

Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.

1 reference

12 December 2020

Mitotic mechanisms in Alzheimer's disease?

1 reference

12 December 2020

Transforming growth factors-beta protect primary rat hippocampal neuronal cultures from degeneration induced by beta-amyloid peptide

1 reference

12 December 2020

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

1 reference

12 December 2020

Transforming growth factor-beta protects human hNT cells from degeneration induced by beta-amyloid peptide: involvement of the TGF-beta type II receptor

1 reference

12 December 2020

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

1 reference

12 December 2020

Transforming growth factor-betas in neurodegenerative disease

1 reference

12 December 2020

Beta-catenin: a key mediator of Wnt signaling

1 reference

12 December 2020

Co-injection of beta-amyloid with ibotenic acid induces synergistic loss of rat hippocampal neurons.

1 reference

12 December 2020

Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield.

1 reference

12 December 2020

The role of neuronal growth factors in neurodegenerative disorders of the human brain

1 reference

12 December 2020

Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion.

1 reference

12 December 2020

Activation of tau protein kinase I/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons.

1 reference

12 December 2020

Transforming growth factor-beta inhibits apoptosis induced by beta-amyloid peptide fragment 25-35 in cultured neuronal cells

1 reference

12 December 2020

Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta

1 reference

12 December 2020

Effects of transforming growth factor-beta (isoforms 1-3) on amyloid-beta deposition, inflammation, and cell targeting in organotypic hippocampal slice cultures.

1 reference

12 December 2020

10.1111/J.1755-5949.2009.00115.X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6493850&resulttype=core&format=json

14 May 2020

1 reference