(Q37682748)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

1 reference

title

C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

main subject

Caenorhabditis elegans

0 references

1 reference

1 reference

Shusei Hamamichi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Kim A Caldwell

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

1 reference

1 May 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

published in

Developmental Dynamics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

239

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

1282-1295

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

17 January 2020

cites work

1 reference

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A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease

21 January 2018

1 reference

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Neurobiology of the Caenorhabditis elegans genome.

21 January 2018

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7 January 2021

Efficacy of multidisciplinary approach in the treatment of two cases of nonclassical infantile glycogenosis type II.

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7 January 2021

Drosophila as a model for human neurodegenerative disease

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7 January 2021

Caenorhabditis elegans MPP+ model of Parkinson's disease for high-throughput drug screenings

1 reference

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7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

1 reference

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7 January 2021

Traversing a wormhole to combat Parkinson's disease

1 reference

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7 January 2021

Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

1 reference

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7 January 2021

Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

1 reference

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7 January 2021

Green fluorescent protein as a marker for gene expression

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1 reference

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7 January 2021

Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkinson's disease: mechanisms and models

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Description of Parkinson's disease as a clinical syndrome.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

alpha-Synuclein affects the MAPK pathway and accelerates cell death

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Repression of alpha-synuclein expression and toxicity by microRNA-7.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Genome-wide RNAi screening in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A MicroRNA feedback circuit in midbrain dopamine neurons

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Loss of autophagy in the central nervous system causes neurodegeneration in mice

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Familial Parkinson mutant alpha-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A systematic RNAi screen reveals involvement of endocytic pathway in neuronal dysfunction in α-synuclein transgenic C . elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human alpha-synuclein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein structures from fluorescence energy-transfer kinetics: implications for the role of the protein in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

https://api.crossref.org/works/10.1002%2FDVDY.22231

1 reference

7 January 2021

Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Dopamine signaling architecture in Caenorhabditis elegans.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha synuclein is present in Lewy bodies in sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

MicroRNAs: something new under the sun

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A genetic screen in Caenorhabditis elegans for dopamine neuron insensitivity to 6-hydroxydopamine identifies dopamine transporter mutants impacting transporter biosynthesis and trafficking

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A cellular model to monitor proteasome dysfunction by alpha-synuclein

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Environmental risk factors and Parkinson's disease: a metaanalysis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein and Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Genomic investigation of alpha-synuclein multiplication and parkinsonism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

The divalent metal transporter homologues SMF-1/2 mediate dopamine neuron sensitivity in caenorhabditis elegans models of manganism and parkinson disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Alpha-synuclein in Lewy bodies

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Expression of A53T mutant but not wild-type alpha-synuclein in PC12 cells induces alterations of the ubiquitin-dependent degradation system, loss of dopamine release, and autophagic cell death.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Dopaminergic neurons in the nematodeCaenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

PINK1 mutations are associated with sporadic early-onset parkinsonism

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Pael-R transgenic mice crossed with parkin deficient mice displayed progressive and selective catecholaminergic neuronal loss

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

α-Synuclein oligomerization: a role for lipids?

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis.

1 reference

https://api.crossref.org/works/10.1002%2FDVDY.22231

7 January 2021

Identifiers

DOI

10.1002/DVDY.22231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20108318%20AND%20SRC:MED&resulttype=core&format=json

release_qgpeihiwkrhw5oeb5u5fprhriu

17 January 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/qgpeihiwkrhw5oeb5u5fprhriu

24 November 2022

mapped directly with Wikidata item

1 reference