(Q37739302)

22 August 2017

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title

Use of in vivo animal models to assess pharmacokinetic drug-drug interactions (English)

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22 August 2017

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Cuyue Tang

1

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22 August 2017

Thomayant Prueksaritanont

series ordinal

2

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22 August 2017

publication date

29 April 2010

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22 August 2017

published in

Pharmaceutical Research

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22 August 2017

volume

27

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22 August 2017

issue

9

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22 August 2017

page(s)

1772-1787

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The effect of probenecid on the renal elimination of cimetidine

22 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS11095-010-0157-Z

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

21 January 2018

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12 December 2020

Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.

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12 December 2020

Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver

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12 December 2020

Substrate specificity and kinetic properties of seven heterologously expressed dog cytochromes p450.

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12 December 2020

The chimpanzee cytochrome P450 3A subfamily: Is our closest related species really that similar?

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12 December 2020

Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates

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12 December 2020

Effects of drug transporters on volume of distribution

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12 December 2020

Comparative inter-species pharmacokinetics of phenoxyacetic acid herbicides and related organic acids. evidence that the dog is not a relevant species for evaluation of human health risk

1 reference

12 December 2020

Kinetic analyses for species differences in P-glycoprotein-mediated drug transport.

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12 December 2020

The complexities of hepatic drug transport: current knowledge and emerging concepts.

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12 December 2020

Progesterone metabolism in hepatic microsomes. Effect of the cytochrome P-450 inhibitor, ketoconazole, and the NADPH 5 alpha-reductase inhibitor, 4-MA, upon the metabolic profile in human, monkey, dog, and rat.

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12 December 2020

Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man.

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12 December 2020

Progress towards prediction of human pharmacokinetic parameters from in vitro technologies.

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12 December 2020

Implications and consequences of enzyme induction on preclinical and clinical drug development

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12 December 2020

In vitro and in vivo CYP3A64 induction and inhibition studies in rhesus monkeys: a preclinical approach for CYP3A-mediated drug interaction studies.

1 reference

12 December 2020

General framework for the prediction of oral drug interactions caused by CYP3A4 induction from in vivo information

1 reference

12 December 2020

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers

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12 December 2020

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization

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12 December 2020

Drug interactions at the blood-brain barrier: fact or fantasy?

1 reference

12 December 2020

In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay

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12 December 2020

Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein.

1 reference

12 December 2020

Characterization of gastrointestinal drug absorption in cynomolgus monkeys

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12 December 2020

Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction

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12 December 2020

Animal data: the contributions of the Ussing Chamber and perfusion systems to predicting human oral drug delivery in vivo

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12 December 2020

Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine.

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12 December 2020

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

1 reference

12 December 2020

Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists

1 reference

12 December 2020

Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes

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12 December 2020

Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.

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12 December 2020

The species differences of intestinal drug absorption and first-pass metabolism between cynomolgus monkeys and humans.

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12 December 2020

Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

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12 December 2020

Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes.

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12 December 2020

Glucuronidation in the chimpanzee (Pan troglodytes): studies with acetaminophen, oestradiol and morphine.

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12 December 2020

Measurements of rat and mouse gastrointestinal pH, fluid and lymphoid tissue, and implications for in-vivo experiments

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12 December 2020

Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption

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12 December 2020

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate

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12 December 2020

Advancement of structure-activity relationship of multidrug resistance-associated protein 2 interactions.

1 reference

12 December 2020

MRP2 mediated drug-drug interaction: indomethacin increases sulfasalazine absorption in the small intestine, potentially decreasing its colonic targeting

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12 December 2020

Scientific and regulatory perspectives on metabolizing enzyme-transporter interplay and its role in drug interactions: challenges in predicting drug interactions

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12 December 2020

CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist

1 reference

12 December 2020

Identification of interspecies difference in hepatobiliary transporters to improve extrapolation of human biliary secretion.

1 reference

12 December 2020

Development and validation of a preclinical food effect model

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12 December 2020

Functional analysis of dog multidrug resistance-associated protein 2 (Mrp2) in comparison with rat Mrp2.

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12 December 2020

A comparison of pharmacokinetics between humans and monkeys

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12 December 2020

Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene

1 reference

12 December 2020

The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model

1 reference

12 December 2020

Effect of oral ketoconazole on oral and intravenous pharmacokinetics of simvastatin and its acid in cynomolgus monkeys

1 reference

12 December 2020

Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells.

1 reference

12 December 2020

Absolute difference of hepatobiliary transporter multidrug resistance-associated protein (MRP2/Mrp2) in liver tissues and isolated hepatocytes from rat, dog, monkey, and human.

1 reference

12 December 2020

A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.

1 reference

12 December 2020

Altered absorption of drugs from the rat small intestine by carbonic anhydrase inhibition

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12 December 2020

Induction of intestinal cytochrome P450 (CYP3A) by rifampicin in beagle dogs

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12 December 2020

Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans

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12 December 2020

The quantitative prediction of in vivo enzyme-induction caused by drug exposure from in vitro information on human hepatocytes

1 reference

12 December 2020

MDR- and CYP3A4-mediated drug-drug interactions

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12 December 2020

Applications and limitations of genetically modified mouse models in drug discovery and development

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12 December 2020

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12 December 2020

Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat.

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12 December 2020

Interplay of drug metabolism and transport: a real phenomenon or an artifact of the site of measurement?

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12 December 2020

Database analyses for the prediction of in vivo drug-drug interactions from in vitro data

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12 December 2020

Predicting drug-drug interactions from in vitro drug metabolism data: challenges and recent advances

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12 December 2020

Kinetic studies on the competition between famotidine and cimetidine in rats. Evidence of multiple renal secretory systems for organic cations

1 reference

12 December 2020

Comparison of species differences of P-glycoproteins in beagle dog, rhesus monkey, and human using Atpase activity assays.

1 reference

12 December 2020

Pharmacokinetics of digoxin in the rat

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12 December 2020

Blood-brain barrier active efflux transporters: ATP-binding cassette gene family

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12 December 2020

Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey

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12 December 2020

The drug transporter-metabolism alliance: uncovering and defining the interplay

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12 December 2020

Potential role of intestinal first-pass metabolism in the prediction of drug–drug interactions

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12 December 2020

Effect of P-glycoprotein-mediated efflux on cerebrospinal fluid concentrations in rhesus monkeys

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12 December 2020

Sequencing and tissue distribution of the canine MRP2 gene compared with MRP1 and MDR1.

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12 December 2020

In vivo evaluation of drug-drug interaction via mechanism-based inhibition by macrolide antibiotics in cynomolgus monkeys

1 reference

12 December 2020

Evaluation of the binding orientations of testosterone in the active site of homology models for CYP2C11 and CYP2C13.

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12 December 2020

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

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12 December 2020

Assessment of drug-drug interactions: concepts and approaches

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12 December 2020

In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier

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12 December 2020

Renal elimination of a novel and potent alphavbeta3 integrin antagonist in animals

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12 December 2020

Effects of uremic toxins on hepatic uptake and metabolism of erythromycin

1 reference

12 December 2020

Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction

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12 December 2020

Species differences in in vitro and in vivo small intestinal metabolism of CYP3A substrates

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12 December 2020

In vivo and in vitro induction of cytochrome P450 enzymes in beagle dogs

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12 December 2020

Effect of SKF 525-A on drug absorption in rats

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12 December 2020

Liver transporters in hepatic drug disposition: an update

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12 December 2020

A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters

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12 December 2020

Pharmacokinetic and pharmacodynamic properties of histamine H2-receptor antagonists. Relationship between intrinsic potency and effective plasma concentrations

1 reference

12 December 2020

The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application

1 reference

12 December 2020

Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide

1 reference

12 December 2020

Establishment and characterization of the transformants stably-expressing MDR1 derived from various animal species in LLC-PK1.

1 reference

12 December 2020

The inhibitory effect of probenecid on renal excretion of famotidine in young, healthy volunteers

1 reference

12 December 2020

Suitability of the Cynomolgus Monkey as an Animal Model for Drug Absorption Studies of Oral Dosage Forms from the Viewpoint of Gastrointestinal Physiology

1 reference

12 December 2020

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux

1 reference

12 December 2020

Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.

1 reference

12 December 2020

Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists

1 reference

12 December 2020

Permeability--in vitro assays for assessing drug transporter activity

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12 December 2020

Diclofenac hydroxylation in monkeys: efficiency, regioselectivity, and response to inhibitors

1 reference

12 December 2020

Rifampin induces the in vitro oxidative metabolism, but not the in vivo clearance of diclofenac in rhesus monkeys

1 reference

12 December 2020

Mechanism-based inactivation of CYP3A by HIV protease inhibitors

1 reference

12 December 2020

Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney

1 reference

12 December 2020

Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors: drug-drug interactions and interindividual differences in transporter and metabolic enzyme functions

1 reference

12 December 2020

Cynomolgus monkey CYPs: a comparison with human CYPs

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12 December 2020

Relationship between drugs and functional activity of various mammalian P-glycoproteins (ABCB1).

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12 December 2020

Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat.

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12 December 2020

Role of cytochrome P450 enzymes in drug-drug interactions.

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12 December 2020

10.1007/S11095-010-0157-Z

Identifiers

DOI

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22 August 2017

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