(Q37845170)

24 August 2017

1 reference

title

Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivity (English)

1 reference

24 August 2017

author name string

Siamak Cyrus Khojasteh

1

1 reference

24 August 2017

Saileta Prabhu

2

1 reference

24 August 2017

Jane R Kenny

3

1 reference

24 August 2017

Jason S Halladay

4

1 reference

24 August 2017

Anthony Y H Lu

5

1 reference

24 August 2017

publication date

19 February 2011

1 reference

European Journal of Drug Metabolism and Pharmacokinetics

24 August 2017

published in

1 reference

24 August 2017

volume

36

1 reference

24 August 2017

issue

1

1 reference

24 August 2017

page(s)

1-16

1 reference

https://scigraph.springernature.com/pub.10.1007/s13318-011-0024-2

24 August 2017

exact match

0 references

cites work

Automated assessment of time-dependent inhibition of human cytochrome P450 enzymes using liquid chromatography-tandem mass spectrometry analysis

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Use of heterologously expressed human cytochrome P4501A2 to predict tacrine-fluvoxamine drug interaction in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Evaluation of fluorescence- and mass spectrometry-based CYP inhibition assays for use in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The conduct of in vitro and in vivo drug-drug interaction studies: a Pharmaceutical Research and Manufacturers of America (PhRMA) perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Characterisation of the cytochrome P450 enzymes involved in the in vitro metabolism of granisetron

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Drug interactions of paclitaxel metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Validation of (-)-N-3-benzyl-phenobarbital as a selective inhibitor of CYP2C19 in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Resveratrol, a red wine constituent, is a mechanism-based inactivator of cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of human cytochrome CYP 1 enzymes by flavonoids of St. John's wort

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

5-substituted, 6-substituted, and unsubstituted 3-heteroaromatic pyridine analogues of nicotine as selective inhibitors of cytochrome P-450 2A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Comparison of cytochrome P450 inhibition assays for drug discovery using human liver microsomes with LC-MS, rhCYP450 isozymes with fluorescence, and double cocktail with LC-MS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations catalyzed by human cytochrome P450 enzymes: a comparison with SKF-525A and ketoconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Progress curve analysis of CYP1A2 inhibition: a more informative approach to the assessment of mechanism-based inactivation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

A novel testosterone 6 beta-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP2C19 inhibition: the impact of substrate probe selection on in vitro inhibition profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Interaction between fibrates and statins--metabolic interactions with gemfibrozil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP2A13 metabolizes the substrates of human CYP1A2, phenacetin, and theophylline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of cytochrome P450 2C9 activity in vitro by 5-hydroxytryptamine and adrenaline

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Cytochrome P450s and other enzymes in drug metabolism and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of CYP2C9 by selective serotonin reuptake inhibitors: in vitro studies with tolbutamide and (S)-warfarin using human liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Human liver microsomal metabolism of the enantiomers of warfarin and acenocoumarol: P450 isozyme diversity determines the differences in their pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibitory effects of neurotransmitters and steroids on human CYP2A6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow-derived macrophages and human haemopoietic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Metabolism and disposition kinetics of nicotine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

In vitro interactions between fluoxetine or fluvoxamine and methadone or buprenorphine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Metabolism of repaglinide by CYP2C8 and CYP3A4 in vitro: effect of fibrates and rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

In vitro inhibition of the cytochrome P450 (CYP450) system by the antiplatelet drug ticlopidine: potent effect on CYP2C19 and CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The effects of selective serotonin reuptake inhibitors and their metabolites on S-mephenytoin 4'-hydroxylase activity in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Enzyme source effects on CYP2C9 kinetics and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Amodiaquine clearance and its metabolism to N-desethylamodiaquine is mediated by CYP2C8: a new high affinity and turnover enzyme-specific probe substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Metabolic interactions of methoxsalen and coumarin in humans and mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Impact of Nonspecific Binding to Microsomes and Phospholipid on the Inhibition of Cytochrome P4502D6: Implications for Relating in Vitro Inhibition Data to in Vivo Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Evaluation of time-dependent cytochrome P450 inhibition using cultured human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Effects of propofol on human hepatic microsomal cytochrome P450 activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The use of caffeine as a metabolic probe for human drug metabolizing enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP2A13 expressed in human bladder metabolically activates 4-aminobiphenyl.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of phenytoin hydroxylation in human liver microsomes by several selective serotonin re-uptake inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The xenobiotic inhibitor profile of cytochrome P4502C8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition by fluoxetine of cytochrome P450 2D6 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Venlafaxine oxidation in vitro is catalysed by CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Characterization of the cytochrome P450 isoenzymes involved in the in vitro N-dealkylation of haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP2A6: a human coumarin 7-hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Effects of fibrates on metabolism of statins in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Mechanism-based inactivation of human cytochrome P450 1A2 by furafylline: detection of a 1:1 adduct to protein and evidence for the formation of a novel imidazomethide intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Fluvoxamine inhibits the CYP2C19-catalysed metabolism of proguanil in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Summary of information on human CYP enzymes: human P450 metabolism data

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibitory effects of the monoamine oxidase inhibitor tranylcypromine on the cytochrome P450 enzymes CYP2C19, CYP2C9, and CYP2D6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP1A1 genotype-selective inhibition of benzo[a]pyrene activation by quercetin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Expression of CYP1A1 and CYP1A2 genes in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Antibodies as a probe in cytochrome P450 research

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibitors of imipramine metabolism by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Selegiline metabolism and cytochrome P450 enzymes: in vitro study in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Utility of recombinant cytochrome p450 enzymes: a drug metabolism perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Trimethoprim and the CYP2C8*3 allele have opposite effects on the pharmacokinetics of pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Microsomal protein concentration modifies the apparent inhibitory potency of CYP3A inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Selective inhibition of CYP2B6-catalyzed bupropion hydroxylation in human liver microsomes in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The functional role of CYP2B6 in human drug metabolism: substrates and inhibitors in vitro, in vivo and in silico.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibitors of alprazolam metabolism in vitro: effect of serotonin-reuptake-inhibitor antidepressants, ketoconazole and quinidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Validated assays for human cytochrome P450 activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Selective inhibition of human cytochrome P4502C8 by montelukast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Examination of 209 drugs for inhibition of cytochrome P450 2C8

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Reaction phenotyping in drug discovery: moving forward with confidence?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Synthetic inhibitors of cytochrome P-450 2A6: inhibitory activity, difference spectra, mechanism of inhibition, and protein cocrystallization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Human liver cytochrome P450 enzymes involved in the 7-hydroxylation of R- and S-warfarin enantiomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13318-011-0024-2

Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions

21 January 2018

1 reference

12 December 2020

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1 reference

12 December 2020

Fluvoxamine is a potent inhibitor of cytochrome P4501A2

1 reference

12 December 2020

Oxidative metabolism of omeprazole in human liver microsomes: cosegregation with S-mephenytoin 4'-hydroxylation

1 reference

12 December 2020

Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19

1 reference

12 December 2020

Human cytochromes mediating N-demethylation of fluoxetine in vitro

1 reference

12 December 2020

Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro.

1 reference

12 December 2020

Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.

1 reference

12 December 2020

Automated high throughput human CYP isoform activity assay using SPE-LC/MS method: application in CYP inhibition evaluation

1 reference

12 December 2020

The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions

1 reference

12 December 2020

Effect of selected antimalarial drugs and inhibitors of cytochrome P-450 3A4 on halofantrine metabolism by human liver microsomes

1 reference

12 December 2020

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

1 reference

12 December 2020

Cytochrome P450 specificity of metabolism and interactions of oxybutynin in human liver microsomes

1 reference

12 December 2020

Biotransformation of taxoids by human cytochromes P450: structure-activity relationship

1 reference

12 December 2020

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

1 reference

12 December 2020

A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6

1 reference

12 December 2020

Participation of CYP2C8 in retinoic acid 4-hydroxylation in human hepatic microsomes

1 reference

12 December 2020

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

1 reference

12 December 2020

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors

1 reference

12 December 2020

Human CYP1B1 and anticancer agent metabolism: mechanism for tumor-specific drug inactivation?

1 reference

12 December 2020

Isoform-selective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline

1 reference

12 December 2020

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8

1 reference

12 December 2020

Human cytochromes P4501A1 and P4501A2: R-warfarin metabolism as a probe

1 reference

12 December 2020

Venlafaxine and metabolites are very weak inhibitors of human cytochrome P450-3A isoforms

1 reference

12 December 2020

Mechanism-based inactivation of human liver cytochrome P450 2A6 by 8-methoxypsoralen

1 reference

12 December 2020

Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma by in situ hybridization

1 reference

12 December 2020

In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s

1 reference

12 December 2020

Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver

1 reference

12 December 2020

Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans

1 reference

12 December 2020

Heterologous expression and kinetic characterization of human cytochromes P-450: validation of a pharmaceutical tool for drug metabolism research

1 reference

12 December 2020

In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (tranylcypromine), and its nonamine analog, cyclopropylbenzene.

1 reference

12 December 2020

High-throughput radiometric CYP2C19 inhibition assay using tritiated (S)-mephenytoin

1 reference

12 December 2020

Human liver CYP2B6-catalyzed hydroxylation of RP 73401

1 reference

12 December 2020

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes

1 reference

12 December 2020

Inhibition by ticlopidine and its derivatives of human liver cytochrome p450. Mechanism-based inactivation of CYP 2C19 by ticlopidine.

1 reference

12 December 2020

[O-ethyl 14C]phenacetin O-deethylase activity in human liver microsomes

1 reference

12 December 2020

Interaction of sulfaphenazole derivatives with human liver cytochromes P450 2C: molecular origin of the specific inhibitory effects of sulfaphenazole on CYP 2C9 and consequences for the substrate binding site topology of CYP 2C9

1 reference

12 December 2020

Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole

1 reference

12 December 2020

A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes.

1 reference

12 December 2020

The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6

1 reference

12 December 2020

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes

1 reference

12 December 2020

Mibefradil is a P-glycoprotein substrate and a potent inhibitor of both P-glycoprotein and CYP3A in vitro.

1 reference

12 December 2020

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus

1 reference

12 December 2020

Fluvoxamine-Clozapine Drug Interaction: Inhibition In Vitro of Five Cytochrome P450 Isoforms Involved in Clozapine Metabolism

1 reference

12 December 2020

Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A

1 reference

12 December 2020

Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity

1 reference

12 December 2020

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry

1 reference

12 December 2020

Fully automated analysis of activities catalysed by the major human liver cytochrome P450 (CYP) enzymes: assessment of human CYP inhibition potential

1 reference

12 December 2020

Hepatic microsomal metabolism of montelukast, a potent leukotriene D4 receptor antagonist, in humans

1 reference

12 December 2020

Inhibition of terfenadine metabolism in vitro by azole antifungal agents and by selective serotonin reuptake inhibitor antidepressants: relation to pharmacokinetic interactions in vivo

1 reference

12 December 2020

Metabolic enantiomeric interactions: the inhibition of human (S)-warfarin-7-hydroxylase by (R)-warfarin

1 reference

12 December 2020

Validation of cytochrome P450 time-dependent inhibition assays: a two-time point IC50 shift approach facilitates kinact assay design

1 reference

12 December 2020

Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation

1 reference

12 December 2020

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

1 reference

12 December 2020

The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways

1 reference

12 December 2020

Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo

1 reference

12 December 2020

Phenacetin O-deethylation by human liver microsomes in vitro: inhibition by chemical probes, SSRI antidepressants, nefazodone and venlafaxine

1 reference

12 December 2020

Assays for CYP1A2 by testing in vivo metabolism of caffeine in humans

1 reference

12 December 2020

Inhibition of coumarin 7-hydroxylase activity in human liver microsomes.

1 reference

12 December 2020

The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.

1 reference

12 December 2020

Identification of human cytochrome P450 isoforms involved in the metabolism of brotizolam

1 reference

12 December 2020

Potent inhibition of yeast-expressed CYP2D6 by dihydroquinidine, quinidine, and its metabolites

1 reference

12 December 2020

CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes

1 reference

12 December 2020

Characterization of the inhibition of P4501A2 by furafylline

1 reference

12 December 2020

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

1 reference

12 December 2020

Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes

1 reference

12 December 2020

Protease inhibitors as inhibitors of human cytochromes P450: high risk associated with ritonavir

1 reference

12 December 2020

Characterization and inhibition of mephenytoin 4-hydroxylase activity in human liver microsomes

1 reference

12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

1 reference

12 December 2020

Ticlopidine inhibition of phenytoin metabolism mediated by potent inhibition of CYP2C19

1 reference

12 December 2020

Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity.

1 reference

12 December 2020

Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments

1 reference

12 December 2020

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

1 reference

12 December 2020

In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A

1 reference

12 December 2020

Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis.

1 reference

12 December 2020

Role of CYP2B6 in stereoselective human methadone metabolism

1 reference

12 December 2020

Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine: comparison with other selective serotonin reuptake inhibitor antidepressants

1 reference

12 December 2020

Mechanism-based inactivation of cytochromes P450 2B1 and P450 2B6 by 2-phenyl-2-(1-piperidinyl)propane

1 reference

12 December 2020

Identification of the human liver cytochrome P450 isoenzyme responsible for the 6-methylhydroxylation of the novel anticancer drug 5,6-dimethylxanthenone-4-acetic acid

1 reference

12 December 2020

Progesterone oxidation by cytochrome P450 2D isoforms in the brain

1 reference

12 December 2020

Detection of cytochrome P450 mRNA transcripts in prostate samples by RT-PCR

1 reference

12 December 2020

Characterization of CYP2A6 involved in 3'-hydroxylation of cotinine in human liver microsomes

1 reference

12 December 2020

Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9

1 reference

12 December 2020

10.1007/S13318-011-0024-2

Identifiers

DOI

1 reference

24 August 2017

1 reference