(Q37943776)

25 August 2017

Focal adhesion kinase and tumour angiogenesis (English)

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25 August 2017

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Kairbaan Hodivala-Dilke

object named as

Kairbaan Hodivala-Dilke

series ordinal

2

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author name string

Tanguy Lechertier

series ordinal

1

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PubMed ID

21984450

25 August 2017

language of work or name

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23 November 2011

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25 August 2017

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25 August 2017

226

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25 August 2017

2

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25 August 2017

404-412

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Angiogenesis in health and disease

25 August 2017

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Integrins in angiogenesis: multitalented molecules in a balancing act.

21 January 2018

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Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

21 January 2018

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Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions

21 January 2018

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Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses

21 January 2018

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Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

21 January 2018

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Integrin-regulated FAK-Src signaling in normal and cancer cells

21 January 2018

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Dual inhibition of focal adhesion kinase and epidermal growth factor receptor pathways cooperatively induces death receptor-mediated apoptosis in human breast cancer cells

21 January 2018

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FAK integrates growth-factor and integrin signals to promote cell migration

21 January 2018

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Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion

21 January 2018

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The role of focal-adhesion kinase in cancer - a new therapeutic opportunity

21 January 2018

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Regulation of focal adhesion kinase by its amino-terminal domain through an autoinhibitory interaction

21 January 2018

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Residues within the first subdomain of the FERM-like domain in focal adhesion kinase are important in its regulation.

21 January 2018

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FERM domain interaction promotes FAK signaling

21 January 2018

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Structural basis for the autoinhibition of focal adhesion kinase

21 January 2018

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Focal adhesion kinase: targeting adhesion signaling pathways for therapeutic intervention

21 January 2018

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Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics

21 January 2018

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Signal transduction by focal adhesion kinase in cancer

21 January 2018

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Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase

21 January 2018

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Autonomous expression of a noncatalytic domain of the focal adhesion-associated protein tyrosine kinase pp125FAK

21 January 2018

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Control of motile and invasive cell phenotypes by focal adhesion kinase.

21 January 2018

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Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells

21 January 2018

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Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase

21 January 2018

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Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: a role for paxillin tyrosine phosphorylation

21 January 2018

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RAFTK/Pyk2-mediated cellular signalling

21 January 2018

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Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain

21 January 2018

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Cloning and characterization of cell adhesion kinase beta, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily

21 January 2018

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Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells

21 January 2018

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Focal adhesion kinase: in command and control of cell motility

21 January 2018

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p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain

21 January 2018

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Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53

21 January 2018

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

21 January 2018

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Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells

21 January 2018

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Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation

21 January 2018

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Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

21 January 2018

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Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

21 January 2018

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FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

21 January 2018

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Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation.

21 January 2018

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Src and focal adhesion kinase as therapeutic targets in cancer

21 January 2018

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Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

21 January 2018

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Cellular characterization of a novel focal adhesion kinase inhibitor

21 January 2018

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Antitumor activity and pharmacology of a selective focal adhesion kinase inhibitor, PF-562,271

21 January 2018

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Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

21 January 2018

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TAE226-induced apoptosis in breast cancer cells with overexpressed Src or EGFR.

21 January 2018

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Therapeutic efficacy of a novel focal adhesion kinase inhibitor TAE226 in ovarian carcinoma

21 January 2018

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Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

21 January 2018

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Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

21 January 2018

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Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model.

21 January 2018

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Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

21 January 2018

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Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment

21 January 2018

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Paradoxical roles of FAK in tumor cell migration and metastasis.

21 January 2018

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Characterization of a novel focal adhesion kinase inhibitor in human platelets.

21 January 2018

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FAK regulates biological processes important for the pathogenesis of cancer

21 January 2018

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Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors

21 January 2018

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Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

21 January 2018

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Autophosphorylation-independent and -dependent functions of focal adhesion kinase during development

21 January 2018

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Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.

21 January 2018

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Bioluminescent imaging study: FAK inhibitor, PF-562,271, preclinical study in PC3M-luc-C6 local implant and metastasis xenograft models

21 January 2018

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Conditional deletion of the focal adhesion kinase FAK alters remodeling of the blood-brain barrier in glioma

21 January 2018

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Endothelial FAK is required for tumour angiogenesis

21 January 2018

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Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

21 January 2018

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Normalization of the vasculature for treatment of cancer and other diseases

21 January 2018

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Role of focal adhesion kinase Ser-732 phosphorylation in centrosome function during mitosis

21 January 2018

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Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases

21 January 2018

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Codon-improved Cre recombinase (iCre) expression in the mouse

21 January 2018

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Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

21 January 2018

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Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome

21 January 2018

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Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PATH.3018

1 reference

25 August 2017

1 reference

PubMed ID

21984450