(Q37968309)

26 August 2017

Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking (English)

1 reference

26 August 2017

Paul Mellor

1

1 reference

26 August 2017

Levi A Furber

series ordinal

2

1 reference

26 August 2017

Jennifer N K Nyarko

series ordinal

3

1 reference

26 August 2017

Deborah H Anderson

series ordinal

4

1 reference

26 August 2017

language of work or name

English

0 references

publication date

1 January 2012

1 reference

26 August 2017

15

1 reference

based on heuristic

inferred from page(s)

published in

Biochemical Journal

1 reference

26 August 2017

441

1 reference

26 August 2017

23-37

1 reference

26 August 2017

1

1 reference

Regulatory subunits of class IA PI3K.

26 August 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Regulation of phosphoinositide 3-kinase expression in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The pleckstrin homology and phosphotyrosine binding domains of insulin receptor substrate 1 mediate inhibition of apoptosis by insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Critical nodes in signalling pathways: insights into insulin action

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol-3-OH kinase as a direct target of Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Role of RAS in the regulation of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Signalling through the lipid products of phosphoinositide-3-OH kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

AKT signaling in physiology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The PKB/AKT pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The PTEN-PI3K pathway: of feedbacks and cross-talks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Regulation of the actin cytoskeleton-plasma membrane interplay by phosphoinositides

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Impairment of dynamin's GAP domain stimulates receptor-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Dynamin undergoes a GTP-dependent conformational change causing vesiculation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Mechanisms of endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Actin dynamics and endocytosis in yeast and mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Dissection of the interplay between class I PI3Ks and Rac signaling in phagocytic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

p85 regulatory subunit of PI3K mediates cAMP-PKA and estrogens biological effects on growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Modification of phosphatidylinositol 3-kinase SH2 domain binding properties by Abl- or Lck-mediated tyrosine phosphorylation at Tyr-688.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85-p110 heterodimerization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Tyrosine 508 of the 85-kilodalton subunit of phosphatidylinositol 3-kinase is phosphorylated by the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Novel pathways of F-actin polymerization in the human neutrophil

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Cytoskeletal reorganization by G protein-coupled receptors is dependent on phosphoinositide 3-kinase gamma, a Rac guanosine exchange factor, and Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphoinositide 3-Kinase Binds Constitutively to / -Tubulin and Binds to -Tubulin in Response to Insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Critical role for Gab2 in transformation by BCR/ABL

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The p85 subunit of phosphoinositide 3-kinase is associated with beta-catenin in the cadherin-based adhesion complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Caspase 8 promotes peripheral localization and activation of Rab5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Using a phage display library to identify basic residues in A-Raf required to mediate binding to the Src homology 2 domains of the p85 subunit of phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Two phosphorylation-independent sites on the p85 SH2 domains bind A-Raf kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A-Raf associates with and regulates platelet-derived growth factor receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The smaller isoforms of ankyrin 3 bind to the p85 subunit of phosphatidylinositol 3'-kinase and enhance platelet-derived growth factor receptor down-regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Intermolecular interactions of the p85alpha regulatory subunit of phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Crystal structure of the breakpoint cluster region-homology domain from phosphoinositide 3-kinase p85 alpha subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Structural studies of the phosphatidylinositol 3-kinase (PI3K) SH3 domain in complex with a peptide ligand: role of the anchor residue in ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

SNX9 - a prelude to vesicle release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol 3-kinase binds to alpha-actinin through the p85 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Mammalian Rho GTPases: new insights into their functions from in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Understanding the catalytic mechanism of GTPase-activating proteins: demonstration of the importance of switch domain stabilization in the stimulation of GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol 3-kinase p85 adaptor function in T-cells. Co-stimulation and regulation of cytokine transcription independent of associated p110.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A PI3K activity-independent function of p85 regulatory subunit in control of mammalian cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Cdc42 and vesicle trafficking in polarized cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Deregulation of Rab5 and Rab4 proteins in p85R274A-expressing cells alters PDGFR trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab GTPases implicated in inherited and acquired disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Role of Rab GTPases in membrane traffic and cell physiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab GTPases as coordinators of vesicle traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Synthesis and function of 3-phosphorylated inositol lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Twice upon a time: PI3K's secret double life exposed

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The emerging mechanisms of isoform-specific PI3K signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Class I PI3K in oncogenic cellular transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Insulin activates the alpha isoform of class II phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The regulation and function of Class III PI3Ks: novel roles for Vps34.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

RAS Interaction with PI3K: More Than Just Another Effector Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Structural effects of oncogenic PI3Kα mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol 3-kinase: the oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The regulation of class IA PI 3-kinases by inter-subunit interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Oncogenic mutations of PIK3CA in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Targeting the PI3K signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

More than just kinases: the scaffolding function of PI3K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Functional analysis of PIK3CA gene mutations in human colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Genetic alteration and expression of the phosphoinositol-3-kinase/Akt pathway genes PIK3CA and PIKE in human glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

BCR-ABL regulates phosphatidylinositol 3-kinase-p110gamma transcription and activation and is required for proliferation and drug resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Targeted RNA interference of phosphatidylinositol 3-kinase p110-beta induces apoptosis and proliferation arrest in endometrial carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A specific function for phosphatidylinositol 3-kinase alpha (p85alpha-p110alpha) in cell survival and for phosphatidylinositol 3-kinase beta (p85alpha-p110beta) in de novo DNA synthesis of human colon carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Biochemical and biological characterization of tumor-associated mutations of p110alpha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The genomic landscapes of human breast and colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Somatic mutations affect key pathways in lung adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

PTEN and the PI3-kinase pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Tenets of PTEN tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The nuclear affairs of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Haplo-insufficiency: a driving force in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

PTEN level in tumor suppression: how much is too little?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Pten is essential for embryonic development and tumour suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Subtle variations in Pten dose determine cancer susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Pten dose dictates cancer progression in the prostate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Membrane-binding and activation mechanism of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Acute ethanol exposure inhibits insulin signaling in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

NHERFs, NEP, MAGUKs, and more: interactions that regulate PTEN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

YXXM motifs in the PDGF-beta receptor serve dual roles as phosphoinositide 3-kinase binding motifs and tyrosine-based endocytic sorting signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Endocytosis and signalling: intertwining molecular networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Signal transduction gRABs attention

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Defining the boundaries: Rab GEFs and GAPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab protein evolution and the history of the eukaryotic endomembrane system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

GTPase-activating proteins: helping hands to complement an active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The emerging shape of the ESCRT machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Derailed endocytosis: an emerging feature of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Aberrant receptor signaling and trafficking as mechanisms in oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The Rab5 effector EEA1 is a core component of endosome docking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The Rab5 effector EEA1 interacts directly with syntaxin-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphatidylinositol-3-OH kinases are Rab5 effectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

PI3KC2α, a class II PI3K, is required for dynamin-independent internalization pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The class II phosphoinositide 3-kinase C2alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Integrin-mediated function of Rab GTPases in cancer progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab5 induces Rac-independent lamellipodia formation and cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Role of rab5 in EGF receptor-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

Rab conversion as a mechanism of progression from early to late endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

The GTPase dynamin binds to and is activated by a subset of SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

PTEN Regulation, a Novel Function for the p85 Subunit of Phosphoinositide 3-Kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20111164

21 January 2018

Identifiers

DOI

10.1042/BJ20111164

1 reference

26 August 2017

1 reference