(Q38013005)

27 August 2017

Energy dysfunction in Huntington's disease: insights from PGC-1α, AMPK, and CKB. (English)

1 reference

27 August 2017

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Yijuang Chern

3

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author name string

Tz-Chuen Ju

series ordinal

1

1 reference

PubMed ID

22627493

27 August 2017

Yow-Sien Lin

series ordinal

2

1 reference

27 August 2017

25 May 2012

1 reference

Cellular and Molecular Life Sciences

27 August 2017

1 reference

27 August 2017

69

1 reference

27 August 2017

24

1 reference

27 August 2017

4107-4120

1 reference

https://scigraph.springernature.com/pub.10.1007/s00018-012-1025-2

27 August 2017

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cites work

Huntington's disease. Pathogenesis and management

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntingtin and the molecular pathogenesis of Huntington's disease. Fourth in molecular medicine review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The role of REST in transcriptional and epigenetic dysregulation in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The role of IκB kinase complex in the neurobiology of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntington's disease: can mice lead the way to treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntington's disease: from molecular pathogenesis to clinical treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mice transgenic for an expanded CAG repeat in the Huntington's disease gene develop diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Impaired glucose tolerance in the R6/1 transgenic mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Progressive formation of inclusions in the striatum and hippocampus of mice transgenic for the human Huntington's disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Cholesterol metabolism in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Increased frequency of diabetes mellitus in patients with Huntington's chorea

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Severe ultrastructural mitochondrial changes in lymphoblasts homozygous for Huntington disease mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Evidence of apoptosis and mitochondrial abnormalities in peripheral blood cells of Huntington's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Effects of overexpression of huntingtin proteins on mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mitochondrial defect in Huntington's disease caudate nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Effect of exogenous and endogenous antioxidants on 3-nitropionic acid-induced in vivo oxidative stress and striatal lesions: insights into Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Evidence of oxidant damage in Huntington's disease: translational strategies using antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Lipoic acid improves survival in transgenic mouse models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mutant huntingtin and mitochondrial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Impaired mitochondrial trafficking in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Peroxisome proliferator-activated receptors: nuclear control of metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Exercise and myocyte enhancer factor 2 regulation in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Restoration of sterol-regulatory-element-binding protein-1c gene expression in HepG2 cells by peroxisome-proliferator-activated receptor-gamma co-activator-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

SUMOylation attenuates the function of PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Impaired PGC-1alpha function in muscle in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Peroxisome-proliferator-activated receptor gamma coactivator 1 α contributes to dysmyelination in experimental models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase signaling in metabolic regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK: a key regulator of energy balance in the single cell and the whole organism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK: a metabolic gauge regulating whole-body energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK: a nutrient and energy sensor that maintains energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK in Health and Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dealing with energy demand: the AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Evidence for the involvement of CaMKII and AMPK in Ca2+-dependent signaling pathways regulating FA uptake and oxidation in contracting rodent muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Regulation of AMP-activated protein kinase by multisite phosphorylation in response to agents that elevate cellular cAMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

PKA phosphorylates and inactivates AMPKalpha to promote efficient lipolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK as a mediator of hormonal signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

5'-AMP-activated protein kinase controls insulin-containing secretory vesicle dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Increased oxygen radical formation and mitochondrial dysfunction mediate beta cell apoptosis under conditions of AMP-activated protein kinase stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Akt activation protects pancreatic beta cells from AMPK-mediated death through stimulation of mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK-beta1 subunit is a p53-independent stress responsive protein that inhibits tumor cell growth upon forced expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase is essential for survival in chronic hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase is activated in Parkinson's disease models mediated by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dietary Aloe Reduces Adipogenesis via the Activation of AMPK and Suppresses Obesity-related Inflammation in Obese Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase: a potential player in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Post-stroke hypothermia provides neuroprotection through inhibition of AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Adenosine monophosphate activated protein kinase inhibition is protective in both sexes after experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Neuroprotective effects of adenosine monophosphate-activated protein kinase inhibition and gene deletion in stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Effects of metformin in experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

AMP-activated protein kinase signaling activation by resveratrol modulates amyloid-beta peptide metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Novel synthetic small-molecule activators of AMPK as enhancers of autophagy and amyloid-β peptide degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

CGS21680 attenuates symptoms of Huntington's disease in a transgenic mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Metformin therapy in a transgenic mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Subcellular localization of creatine kinase in Torpedo electrocytes: association with acetylcholine receptor-rich membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Intracellular compartmentation, structure and function of creatine kinase isoenzymes in tissues with high and fluctuating energy demands: the 'phosphocreatine circuit' for cellular energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Flow of energy in the outer retina in darkness and in light.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Hair bundles are specialized for ATP delivery via creatine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Creatine kinase in non-muscle tissues and cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Thrombin modulates and reverses neuroblastoma neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Interaction of neuron-specific K+-Cl- cotransporter, KCC2, with brain-type creatine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Hereditary motor and sensory neuropathy with agenesis of the corpus callosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The expression of creatine kinase isoenzymes in neocortex of patients with neurodegenerative disorders: Alzheimer's and Pick's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Oxidation of cytosolic proteins and expression of creatine kinase BB in frontal lobe in different neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Oxidative modification of creatine kinase BB in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Proteomic and oxidative stress analysis in human brain samples of Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Proteomic analysis of protein expression and oxidative modification in r6/2 transgenic mice: a model of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Reduced creatine kinase as a central and peripheral biomarker in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Proteomic changes in the brains of Huntington's disease mouse models reflect pathology and implicate mitochondrial changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Early alterations of brain cellular energy homeostasis in Huntington disease models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

KCC2 interacts with the dendritic cytoskeleton to promote spine development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Huntingtin inclusion bodies are iron-dependent centers of oxidative events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Direct antioxidant properties of creatine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Creatine in mouse models of neurodegeneration and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Creatine and cyclocreatine attenuate MPTP neurotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Functions and effects of creatine in the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Kinetics of creatine in blood and brain after intraperitoneal injection in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mouse p53 represses the rat brain creatine kinase gene but activates the rat muscle creatine kinase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

The generation of the oxidized form of creatine kinase is a negative regulation on muscle creatine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Arginine:glycine amidinotransferase deficiency: the third inborn error of creatine metabolism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Creatine depletion in a new case with AGAT deficiency: clinical and genetic study in a large pedigree

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

X-linked creatine-transporter gene (SLC6A8) defect: a new creatine-deficiency syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

X-linked creatine deficiency syndrome: a novel mutation in creatine transporter gene SLC6A8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Diffuse Lewy Body Disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Rapidly progressive diffuse Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Impaired brain creatine kinase activity in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Bioenergetics: Dissecting the role of creatine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-012-1025-2

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

21 January 2018

1 reference

12 December 2020

1 reference

12 December 2020

Huntingtin aggregate-associated axonal degeneration is an early pathological event in Huntington's disease mice.

1 reference

12 December 2020

Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice

1 reference

12 December 2020

Creatine kinase is the main target of reactive oxygen species in cardiac myofibrils

1 reference

12 December 2020

Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase

1 reference

12 December 2020

Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man

1 reference

12 December 2020

Creatine kinase B is a target molecule of reactive oxygen species in cervical cancer.

1 reference

12 December 2020

Therapeutic effects of coenzyme Q10 and remacemide in transgenic mouse models of Huntington's disease.

1 reference

12 December 2020

Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter

1 reference

12 December 2020

Creatine and creatinine metabolism

1 reference

12 December 2020

Higher sedentary energy expenditure in patients with Huntington's disease

1 reference

12 December 2020

Neuropathological classification of Huntington's disease

1 reference

12 December 2020

Functional significance of cell volume regulatory mechanisms.

1 reference

12 December 2020

Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation

1 reference

12 December 2020

Cell type-specific differences in chloride-regulatory mechanisms and GABA(A) receptor-mediated inhibition in rat substantia nigra

1 reference

12 December 2020

Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease.

1 reference

12 December 2020

Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum.

1 reference

12 December 2020

PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle

1 reference

12 December 2020

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling

1 reference

12 December 2020

Thrombin receptor activation protects neurons and astrocytes from cell death produced by environmental insults.

1 reference

12 December 2020

Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors

1 reference

12 December 2020

Neuroprotective effects of creatine in a transgenic mouse model of Huntington's disease.

1 reference

12 December 2020

10.1007/S00018-012-1025-2

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22627493