(Q38014338)

27 August 2017

title

Analysis of the regulatory and catalytic domains of PTEN-induced kinase-1 (PINK1). (English)

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27 August 2017

Heung-Chin Cheng

5

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author name string

Chou Hung Sim

1

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27 August 2017

Kipros Gabriel

2

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27 August 2017

Ryan D Mills

3

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27 August 2017

Janetta G Culvenor

4

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27 August 2017

publication date

5 July 2012

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27 August 2017

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27 August 2017

volume

33

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27 August 2017

issue

10

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27 August 2017

page(s)

1408-1422

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Artificial mitochondrial presequences

27 August 2017

cites work

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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability

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Chapter 10 Analysis and prediction of mitochondrial targeting peptides

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PINK1 protein in normal human brain and Parkinson's disease

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Targeting of Neisserial PorB to the mitochondrial outer membrane: an insight on the evolution of β-barrel protein assembly machines

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Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

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PINK1- and Parkin-mediated mitophagy at a glance

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Dynamics of cAMP-dependent protein kinase

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Structure and chemical inhibition of the RET tyrosine kinase domain

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Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin

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Characterization of PINK1 processing, stability, and subcellular localization

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Mitochondrial dynamics and neurodegeneration

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Recent advances in the genetics of Parkinson's disease

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Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport

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The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

21 January 2018

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The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy

21 January 2018

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Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

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Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

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Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors

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Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress

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A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2

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PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

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21 January 2018

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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations

21 January 2018

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21 January 2018

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The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway

21 January 2018

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Protein unfolding in the cell

21 January 2018

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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1

21 January 2018

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21 January 2018

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Effect of endogenous mutant and wild-type PINK1 on Parkin in fibroblasts from Parkinson disease patients

21 January 2018

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The mitochondrial import machinery for preproteins

21 January 2018

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Oncoprotein Akt/PKB induces trophic effects in murine models of Parkinson's disease

21 January 2018

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Predikin and PredikinDB: a computational framework for the prediction of protein kinase peptide specificity and an associated database of phosphorylation sites

21 January 2018

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Mitochondrial protein import: from proteomics to functional mechanisms

21 January 2018

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Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

21 January 2018

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Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

21 January 2018

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21 January 2018

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21 January 2018

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C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.

21 January 2018

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Autoactivation of catalytic (C alpha) subunit of cyclic AMP-dependent protein kinase by phosphorylation of threonine 197

21 January 2018

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Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1.

21 January 2018

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Structural framework for the protein kinase family

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22127

Understanding and exploiting substrate recognition by protein kinases

21 January 2018

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Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates

21 January 2018

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Principles governing amino acid composition of integral membrane proteins: application to topology prediction

21 January 2018

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The HMMTOP transmembrane topology prediction server

21 January 2018

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Mechanisms of specificity in protein phosphorylation

21 January 2018

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Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain

21 January 2018

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

21 January 2018

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Membrane topology and insertion of membrane proteins: search for topogenic signals

21 January 2018

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

21 January 2018

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Membrane protein structure prediction. Hydrophobicity analysis and the positive-inside rule

21 January 2018

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Membrane protein assembly: rules of the game

21 January 2018

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Membrane-protein topology

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22127

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

21 January 2018

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Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.

21 January 2018

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking

21 January 2018

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Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

21 January 2018

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

21 January 2018

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Mitochondrial morphogenesis, distribution, and Parkinson disease: insights from PINK1

21 January 2018

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Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane

21 January 2018

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21 January 2018

Mechanisms of mitophagy

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Atomic structure of the MAP kinase ERK2 at 2.3 A resolution

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22127

Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22127

2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FHUMU.22127

The kinase domain of mitochondrial PINK1 faces the cytoplasm

21 January 2018

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https://api.crossref.org/works/10.1002%2FHUMU.22127

The signal that sorts yeast cytochrome b2 to the mitochondrial intermembrane space contains three distinct functional regions

21 January 2018

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7 January 2021

Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan

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7 January 2021

The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification 1

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7 January 2021

Successive translocation into and out of the mitochondrial matrix: targeting of proteins to the intermembrane space by a bipartite signal peptide

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https://api.crossref.org/works/10.1002%2FHUMU.22127

7 January 2021

Powering mitochondrial protein import

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https://api.crossref.org/works/10.1002%2FHUMU.22127

7 January 2021

Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides

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7 January 2021

Domain structure of mitochondrial and chloroplast targeting peptides

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7 January 2021

Identifiers

DOI

10.1002/HUMU.22127

1 reference

27 August 2017

1 reference