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Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism.
scientific article published on 09 July 2009
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
main subject
autophagy
0 references
mitochondrion
1 reference
based on heuristic
inferred from title
Parkinson's disease
1 reference
based on heuristic
inferred from title
author
Charleen T. Chu
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
author name string
Charleen T Chu
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2790548
retrieved
20 August 2017
language of work or name
English
0 references
publication date
9 July 2009
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
published in
Biochimica et Biophysica Acta
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
volume
1802
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
issue
1
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
page(s)
20-28
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
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Mitochondrial alterations in PINK1 deficient cells are influenced by calcineurin-dependent dephosphorylation of dynamin-related protein 1.
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FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation
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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth
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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation
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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking
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Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
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23 August 2017
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.
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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
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Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
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Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death
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6-Hydroxydopamine induces mitochondrial ERK activation.
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PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
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23 August 2017
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
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Selective degradation of mitochondria by mitophagy
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23 August 2017
Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death
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23 August 2017
The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function
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23 August 2017
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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23 August 2017
Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease
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23 August 2017
Kinase signaling cascades in the mitochondrion: a matter of life or death.
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23 August 2017
PINK1 (PARK6) associated Parkinson disease in Ireland
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23 August 2017
Novel PINK1 mutations in early-onset parkinsonism
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23 August 2017
PINK1 mutations are associated with sporadic early-onset parkinsonism
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23 August 2017
Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
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23 August 2017
Genetic clues to the pathogenesis of Parkinson's disease
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Parkinson's disease transgenic mitochondrial cybrids generate Lewy inclusion bodies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Molecular Pathways of Neurodegeneration in Parkinson's Disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Parkinson's disease: mechanisms and models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Parkinson's disease: piecing together a genetic jigsaw
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Autophagosome formation in mammalian cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Mechanistic approaches to Parkinson's disease pathogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Failure of the ubiquitin-proteasome system in Parkinson's disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
23 August 2017
Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Parkin stabilizes PINK1 through direct interaction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Molecular interaction between parkin and PINK1 in mammalian neuronal cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
6-Hydroxydopamine (6-OHDA) induces Drp1-dependent mitochondrial fragmentation in SH-SY5Y cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Silencing of the Pink1 gene expression by conditional RNAi does not induce dopaminergic neuron death in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Parkin enhances mitochondrial biogenesis in proliferating cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
14 September 2017
Pink1 suppresses alpha-synuclein-induced phenotypes in a Drosophila model of Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
PINK1 heterozygous rare variants: prevalence, significance and phenotypic spectrum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial fusion protects against neurodegeneration in the cerebellum.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial aberrations in mucolipidosis Type IV.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial trafficking to synapses in cultured primary cortical neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Distribution of PINK1 and LRRK2 in rat and mouse brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Homozygous PINK1 C-terminus mutation causing early-onset parkinsonism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Axonal mitochondrial transport and potential are correlated
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondrial abnormalities in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mitochondria are selectively eliminated from eukaryotic cells after blockade of caspases during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Understanding cell death in Parkinson's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Mechanisms of MPTP toxicity.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
2 September 2018
Lipid oxidation and autophagy in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790548
retrieved
3 December 2018
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19595762
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19595762
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.BBADIS.2009.06.012
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PMCID
2790548
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
PubMed ID
19595762
1 reference
stated in
Europe PubMed Central
PMCID
2790548
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19595762%20AND%20SRC:MED&resulttype=core&format=json
retrieved
2 February 2020
ResearchGate publication ID
222259000
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