(Q38020955)

27 August 2017

title

Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis (English)

1 reference

27 August 2017

0 references

Calliope A Dendrou

2

0 references

Lars Fugger

series ordinal

3

object named as

Lars Fugger

1 reference

27 August 2017

Kathrine E Attfield

1

1 reference

27 August 2017

language of work or name

1 reference

1 July 2012

1 reference

27 August 2017

published in

Immunological Reviews

1 reference

27 August 2017

volume

248

1 reference

27 August 2017

issue

1

1 reference

27 August 2017

page(s)

10-22

1 reference

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

27 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Risk alleles for multiple sclerosis identified by a genomewide study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Next-generation DNA sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A map of human genome variation from population-scale sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Accurate whole human genome sequencing using reversible terminator chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Progress and challenges in genome-wide association studies in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Initial impact of the sequencing of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

From genes to function: the next challenge to understanding multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Multiple sclerosis genetics--is the glass half full, or half empty?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Genotype to phenotype: a complex problem

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Epistatic selection between coding and regulatory variation in human evolution and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Functional genomics: The changes that count.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Gene--environment-wide association studies: emerging approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A functional and structural basis for TCR cross-reactivity in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A prescription for human immunology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Autoimmunity's next top models

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The relation between inflammation and neurodegeneration in multiple sclerosis brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Selection and fine-tuning of the autoimmune T-cell repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Twin studies and the heritability of MS: a conclusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Infectious triggers protect from autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

CD8-deficient SJL mice display enhanced susceptibility to Theiler's virus infection and increased demyelinating pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Role of CD8+ T cells in murine experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Encephalitogenicity of complete Freund's adjuvant relative to CpG is linked to induction of Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

B lymphocytes producing demyelinating autoantibodies: development and function in gene-targeted transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The NIH Human Microbiome Project

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Interactions between commensal intestinal bacteria and the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Commensal host-bacterial relationships in the gut

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The interplay between microbiome dynamics and pathogen dynamics in a murine model of Clostridium difficile Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The T lymphocyte in experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Fate mapping of IL-17-producing T cells in inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Environmental risk factors in multiple sclerosis aetiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Molecular mimicry and multiple sclerosis: degenerate T-cell recognition and the induction of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Phylogeny of gammaproteobacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The risk of relapses in multiple sclerosis during systemic infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Diabetes induced by Coxsackie virus: initiation by bystander damage and not molecular mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Presented antigen from damaged pancreatic beta cells activates autoreactive T cells in virus-mediated autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Epitope spreading and molecular mimicry as triggers of autoimmunity in the Theiler's virus-induced demyelinating disease model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Pronuclear injection for the production of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Altering the genome by homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A novel TNFRSF1A splice mutation associated with increased nuclear factor kappaB (NF-kappaB) transcription factor activation in patients with tumour necrosis factor receptor associated periodic syndrome (TRAPS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Recombineering: a homologous recombination-based method of genetic engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Cre recombinase: The universal reagent for genome tailoring

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

High-efficiency FLP and PhiC31 site-specific recombination in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A comparison of exogenous promoter activity at the ROSA26 locus using a ΦiC31 integrase mediated cassette exchange approach in mouse ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A modified RMCE-compatible Rosa26 locus for the expression of transgenes from exogenous promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Control of TH17 cells occurs in the small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A rapid and scalable system for studying gene function in mice using conditional RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Constitutive and conditional RNAi transgenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Recombineering: a powerful new tool for mouse functional genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Serine recombinases as tools for genome engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

The problems and promises of research into human immunology and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

Polygenic control of susceptibility to murine systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1600-065X.2012.01132.X

10.1111/J.1600-065X.2012.01132.X

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference