(Q38028791)

27 August 2017

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies (English)

1 reference

27 August 2017

1

Emmanouil Fokas

1 reference

27 August 2017

W Gillies McKenna

2

1 reference

PubMed ID

22825313

27 August 2017

Ruth J Muschel

series ordinal

3

1 reference

27 August 2017

1 December 2012

1 reference

Cancer and Metastasis Reviews

27 August 2017

1 reference

27 August 2017

31

1 reference

27 August 2017

3-4

1 reference

27 August 2017

823-842

1 reference

https://scigraph.springernature.com/pub.10.1007/s10555-012-9394-4

27 August 2017

0 references

cites work

The role of radiotherapy in cancer treatment: estimating optimal utilization from a review of evidence-based clinical guidelines

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Improving quality of patient care by improving daily practice in radiation oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Innovations in image-guided radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Advances in radiation therapy: conventional to 3D, to IMRT, to 4D, and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Molecular strategies targeting the host component of cancer to enhance tumor response to radiation therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Strategies to improve radiotherapy with targeted drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Guidelines for preclinical and early phase clinical assessment of novel radiosensitisers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

21 January 2018

The 5Rs of radiobiology

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia--a key regulatory factor in tumour growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The impact of O2 availability on human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia in tumors: a paradigm for the approach to biochemical and physiologic heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia-inducible factors in physiology and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Molecular mechanisms and clinical applications of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Impact of hemoglobin levels on tumor oxygenation: the higher, the better?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The anaemia of cancer: death by a thousand cuts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia in cancer: significance and impact on clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Angiogenesis in life, disease and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumor angiogenesis: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumorigenesis and the angiogenic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

VEGF and the quest for tumour angiogenesis factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Premetastatic lung "niche": is vascular endothelial growth factor receptor 1 activation required?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The multifaceted circulating endothelial cell in cancer: towards marker and target identification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Exploiting tumour hypoxia in cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumor microenvironmental physiology and its implications for radiation oncology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Drug resistance and the solid tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumor hypoxia: its impact on cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxic Stress Proteins: Survival of the Fittest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia-mediated drug resistance: novel insights on the functional interaction of HIFs and cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Does the tumor microenvironment influence radiation-induced apoptosis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Chronic suppression of angiogenesis following radiation exposure is independent of hematopoietic reconstitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Matrix metalloproteinase-9 is required for tumor vasculogenesis but not for angiogenesis: role of bone marrow-derived myelomonocytic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Is vasculogenesis crucial for the regrowth of irradiated tumours?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Delta-like ligand 4-notch blockade and tumor radiation response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The pathology of ionizing radiation as defined by morphologic patterns.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Irradiation-dependent effects on tumor perfusion and endogenous and exogenous hypoxia markers in an A549 xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Radiation enhancement of metastasis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Microenvironment-induced cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Ionizing radiation enhances matrix metalloproteinase-2 secretion and invasion of glioma cells through Src/epidermal growth factor receptor-mediated p38/Akt and phosphatidylinositol 3-kinase/Akt signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The tumor bed effect: increased metastatic dissemination from hypoxia-induced up-regulation of metastasis-promoting gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Inhibition of the Kit ligand/c-Kit axis attenuates metastasis in a mouse model mimicking local breast cancer relapse after radiotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Flow cytometric determination of the time of metastasis during fractionated radiation therapy of the rat rhabdomyosarcoma R1H.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Drug penetration in solid tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Drug distribution in tumors: mechanisms, role in drug resistance, and methods for modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Pancreatic stellate cells radioprotect pancreatic cancer cells through β1-integrin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

High interstitial fluid pressure - an obstacle in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The human tumor microenvironment: invasive (needle) measurement of oxygen and interstitial fluid pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

A tense situation: forcing tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The universal dynamics of tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Disrupting tumour blood vessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Targeting VEGF-A to treat cancer and age-related macular degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Angiogenesis inhibitors: current strategies and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Mechanisms of disease: the PI3K-Akt-PTEN signaling node--an intercept point for the control of angiogenesis in brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

'Accidental' anti-angiogenic drugs. anti-oncogene directed signal transduction inhibitors and conventional chemotherapeutic agents as examples

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The RAS signal transduction pathway and its role in radiation sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Enhanced radiation damage of tumor vasculature by mTOR inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Antiangiogenic therapy with mammalian target of rapamycin inhibitor RAD001 (Everolimus) increases radiosensitivity in solid cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The PI3K pathway as drug target in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

mTOR: from growth signal integration to cancer, diabetes and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

TOR signaling in growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The phosphoinositide 3-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Ras, PI(3)K and mTOR signalling controls tumour cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

High frequency of mutations of the PIK3CA gene in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

K-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Deficiency in the p110alpha subunit of PI3K results in diminished Tie2 expression and Tie2(-/-)-like vascular defects in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

H-ras regulates angiogenesis and vascular permeability by activation of distinct downstream effectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Cobalt induces hypoxia-inducible factor-1alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Vascular endothelial growth factor transcriptional activation is mediated by hypoxia-inducible factor 1alpha, HDM2, and p70S6K1 in response to phosphatidylinositol 3-kinase/AKT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Akt-mediated activation of HIF-1 in pulmonary vascular endothelial cells by S-nitrosoglutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Mast cells can mediate vascular permeability through regulation of the PI3K-HIF-1alpha-VEGF axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Involvement of PI3K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Phosphatidylinositol 3-kinase mediates angiogenesis and vascular permeability associated with ovarian carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Microvascular patterning is controlled by fine-tuning the Akt signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Class 1A PI3K regulates vessel integrity during development and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumor vascular changes mediated by inhibition of oncogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Palomid 529, a novel small-molecule drug, is a TORC1/TORC2 inhibitor that reduces tumor growth, tumor angiogenesis, and vascular permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Time-course imaging of therapeutic functional tumor vascular normalization by antiangiogenic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Response of U87 glioma xenografts treated with concurrent rapamycin and fractionated radiotherapy: possible role for thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fr

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Suramin treatment of human glioma xenografts; effects on tumor vasculature and oxygenation status

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Tumour biology: herceptin acts as an anti-angiogenic cocktail.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Endogenous Myc maintains the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

The mitogen-activated protein/extracellular signal-regulated kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) enhances the radiation responsiveness of lung and colorectal tumor xenografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: importance of optimal scheduling to exploit the 'normalization' window of the tumor vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Improved intratumoral oxygenation through vascular normalization increases glioma sensitivity to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Alphavbeta3/alphavbeta5 integrins-FAK-RhoB: a novel pathway for hypoxia regulation in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Bevacizumab-induced transient remodeling of the vasculature in neuroblastoma xenografts results in improved delivery and efficacy of systemically administered chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Efficacy, safety, and biomarkers of neoadjuvant bevacizumab, radiation therapy, and fluorouracil in rectal cancer: a multidisciplinary phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: schedule-dependent enhancement of antitumor activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Inhibition of alpha(v)beta3 integrin survival signaling enhances antiangiogenic and antitumor effects of radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Trimodal cancer treatment: beneficial effects of combined antiangiogenesis, radiation, and chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Modulation of the tumor microvasculature by phosphoinositide-3 kinase inhibition increases doxorubicin delivery in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Blockade of TGF-β signaling by the TGFβR-I kinase inhibitor LY2109761 enhances radiation response and prolongs survival in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Differential effect of sunitinib on the distribution of temozolomide in an orthotopic glioma model

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Effect of tumor microenvironment modulation on the efficacy of oncolytic virus therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Scheduling of radiation with angiogenesis inhibitors anginex and Avastin improves therapeutic outcome via vessel normalization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Selective alpha-particle mediated depletion of tumor vasculature with vascular normalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Rapid decrease in delivery of chemotherapy to tumors after anti-VEGF therapy: implications for scheduling of anti-angiogenic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Vascular toxicity of antineoplastic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

CT findings of chemotherapy-induced toxicity: what radiologists need to know about the clinical and radiologic manifestations of chemotherapy toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Antiangiogenic effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Exploring the role of cancer stem cells in radioresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

A perivascular niche for brain tumor stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Cancer stem cells as a predictive factor in radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Predictive biomarkers of sensitivity to the phosphatidylinositol 3' kinase inhibitor GDC-0941 in breast cancer preclinical models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Role of Oxygen in Modifying the Radiosensitivity of E. Coli B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10555-012-9394-4

10.1007/S10555-012-9394-4

21 January 2018

Identifiers

DOI

1 reference

PubMed ID

22825313

Dimensions Publication ID

27 August 2017

0 references

1 reference

PubMed ID

22825313