(Q38042021)

27 August 2017

Recent agents targeting HIF-1α for cancer therapy (English)

1 reference

27 August 2017

Yaozhong Hu

1

1 reference

PubMed ID

22961911

27 August 2017

Jing Liu

series ordinal

2

1 reference

PubMed ID

22961911

27 August 2017

He Huang

series ordinal

3

1 reference

27 August 2017

1 March 2013

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Journal of Cellular Biochemistry

27 August 2017

1 reference

27 August 2017

114

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27 August 2017

498-509

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27 August 2017

3

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Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis

27 August 2017

1 reference

Resveratrol: a review of preclinical studies for human cancer prevention

21 January 2018

1 reference

Phage display technology: clinical applications and recent innovations

21 January 2018

1 reference

Hypoxia inducible factor-1: a novel target for cancer therapy

21 January 2018

1 reference

A phase 2 trial of flavopiridol (Alvocidib) and cisplatin in platin-resistant ovarian and primary peritoneal carcinoma: MC0261

21 January 2018

1 reference

Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma

21 January 2018

1 reference

Flavopiridol, an inhibitor of transcription: implications, problems and solutions

21 January 2018

1 reference

Phase I trial of the combination of flavopiridol and imatinib mesylate in patients with Bcr-Abl+ hematological malignancies.

21 January 2018

1 reference

New phosphatidylinositol 3-kinase inhibitors for cancer

21 January 2018

1 reference

Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo

21 January 2018

1 reference

YC-1 exerts inhibitory effects on MDA-MB-468 breast cancer cells by targeting EGFR in vitro and in vivo under normoxic condition

21 January 2018

1 reference

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells.

21 January 2018

1 reference

Versatile pharmacological actions of YC-1: anti-platelet to anticancer

21 January 2018

1 reference

Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis

21 January 2018

1 reference

In vivo and in vitro effects of a HIF-1alpha inhibitor, RX-0047.

21 January 2018

1 reference

Chemoprotection against cancer by isothiocyanates: a focus on the animal models and the protective mechanisms

21 January 2018

1 reference

Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.

21 January 2018

1 reference

Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

21 January 2018

1 reference

Geldanamycin and its derivatives as Hsp90 inhibitors

21 January 2018

1 reference

Identification by phage display of single-domain antibody fragments specific for the ODD domain in hypoxia-inducible factor 1alpha

21 January 2018

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Naturally occurring antibodies devoid of light chains

21 January 2018

1 reference

Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.

21 January 2018

1 reference

Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol

21 January 2018

1 reference

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture

21 January 2018

1 reference

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

21 January 2018

1 reference

Identification of novel small-molecule inhibitors of hypoxia-inducible factor-1 transactivation and DNA binding

21 January 2018

1 reference

Novel thioredoxin inhibitors paradoxically increase hypoxia-inducible factor-alpha expression but decrease functional transcriptional activity, DNA binding, and degradation

21 January 2018

1 reference

Wondonin, a novel compound, inhibits hypoxia-induced angiogenesis through hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

HIF-1α inhibition by siRNA or chetomin in human malignant glioma cells: effects on hypoxic radioresistance and monitoring via CA9 expression

21 January 2018

1 reference

Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity

21 January 2018

1 reference

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

21 January 2018

1 reference

A radicicol derivative, KF58333, inhibits expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, angiogenesis and growth of human breast cancer xenografts

21 January 2018

1 reference

Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.

21 January 2018

1 reference

A novel approach to cancer therapy using PX-478 as a HIF-1α inhibitor

21 January 2018

1 reference

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

21 January 2018

1 reference

A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}.

21 January 2018

1 reference

Cancer therapy by targeting hypoxia-inducible factor-1.

21 January 2018

1 reference

Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells

21 January 2018

1 reference

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

1 reference

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

21 January 2018

1 reference

2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.

21 January 2018

1 reference

Inhibition of hypoxia-induced angiogenesis by FK228, a specific histone deacetylase inhibitor, via suppression of HIF-1alpha activity

21 January 2018

1 reference

Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers.

21 January 2018

1 reference

Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy

21 January 2018

1 reference

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

21 January 2018

1 reference

Hypoxia enhances LPA-induced HIF-1alpha and VEGF expression: their inhibition by resveratrol

21 January 2018

1 reference

Class II histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha

21 January 2018

1 reference

Production of novel recombinant single-domain antibodies against tandem repeat region of MUC1 mucin

21 January 2018

1 reference

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination.

21 January 2018

1 reference

MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

21 January 2018

1 reference

Targeting HIF-1 for cancer therapy

21 January 2018

1 reference

Hypoxia-inducible factor 1 (HIF-1) pathway

21 January 2018

1 reference

Structural and functional analysis of hypoxia-inducible factor 1.

21 January 2018

1 reference

Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice.

21 January 2018

1 reference

Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1.

21 January 2018

1 reference

Anticancer activities of alkylating pyrrole-imidazole polyamides with specific sequence recognition

21 January 2018

1 reference

The crystal structure of a llama heavy chain variable domain

21 January 2018

1 reference

Camelid heavy-chain variable domains provide efficient combining sites to haptens

21 January 2018

1 reference

Effects of HIF-1 inhibition by chetomin on hypoxia-related transcription and radiosensitivity in HT 1080 human fibrosarcoma cells

21 January 2018

1 reference

YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia

21 January 2018

1 reference

Angiogenic signaling aberrantly induced by tumor hypoxia

21 January 2018

1 reference

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

21 January 2018

1 reference

Nanobodies®: new ammunition to battle viruses

21 January 2018

1 reference

Combination strategy targeting the hypoxia inducible factor-1 alpha with mammalian target of rapamycin and histone deacetylase inhibitors

21 January 2018

1 reference

Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions

21 January 2018

1 reference

CCI-779 inhibits rhabdomyosarcoma xenograft growth by an antiangiogenic mechanism linked to the targeting of mTOR/Hif-1alpha/VEGF signaling

21 January 2018

1 reference

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

21 January 2018

1 reference

Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.

21 January 2018

1 reference

Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors

21 January 2018

1 reference

YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.

21 January 2018

1 reference

Amphotericin B blunts erythropoietin response to hypoxia by reinforcing FIH-mediated repression of HIF-1.

21 January 2018

1 reference

Application of phage display technology to cancer research

21 January 2018

1 reference

Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells.

21 January 2018

1 reference

Resveratrol inhibits hypoxia-induced accumulation of hypoxia-inducible factor-1alpha and VEGF expression in human tongue squamous cell carcinoma and hepatoma cells

21 January 2018

1 reference

A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/JCB.24390

1 reference

27 August 2017

1 reference

PubMed ID

22961911