(Q38047182)

27 August 2017

The NAD metabolome--a key determinant of cancer cell biology (English)

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27 August 2017

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Alberto Chiarugi

1

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27 August 2017

Christian Dölle

series ordinal

2

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27 August 2017

Roberta Felici

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3

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27 August 2017

Mathias Ziegler

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4

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27 August 2017

language of work or name

English

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publication date

28 September 2012

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27 August 2017

Nature Reviews Cancer

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27 August 2017

12

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27 August 2017

741-752

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27 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrc3340

27 August 2017

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cites work

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31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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The new life of a centenarian: signalling functions of NAD(P).

31 March 2020

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The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways

31 March 2020

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Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

31 March 2020

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Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms

31 March 2020

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The NMN/NaMN adenylyltransferase (NMNAT) protein family.

31 March 2020

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Enzymology of mammalian NAD metabolism in health and disease

31 March 2020

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The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate

31 March 2020

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NAD+biosynthesis and salvage - a phylogenetic perspective

31 March 2020

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Poly(ADP-ribose). The most elaborate metabolite of NAD+.

31 March 2020

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The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.

31 March 2020

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Poly(ADP-ribose): novel functions for an old molecule

31 March 2020

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Magnitude and significance of NAD turnover in human cell line D98/AH2

31 March 2020

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

31 March 2020

1 reference

Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis

31 March 2020

1 reference

Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony-enhancing factor

31 March 2020

1 reference

Nampt: linking NAD biology, metabolism and cancer

31 March 2020

1 reference

Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma

31 March 2020

1 reference

Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

31 March 2020

1 reference

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

31 March 2020

1 reference

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

1 reference

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

31 March 2020

1 reference

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

31 March 2020

1 reference

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

31 March 2020

1 reference

Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose

31 March 2020

1 reference

Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel.

31 March 2020

1 reference

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling

31 March 2020

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Decreased cADPR and increased NAD+ in the Cd38-/- mouse.

31 March 2020

1 reference

CD38 and chronic lymphocytic leukemia: a decade later

31 March 2020

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CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions

31 March 2020

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Mammalian ADP-ribosyltransferases and ADP-ribosylhydrolases

31 March 2020

1 reference

ADP-ribosylarginine hydrolase regulates cell proliferation and tumorigenesis

31 March 2020

1 reference

PARP inhibition: PARP1 and beyond

31 March 2020

1 reference

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

31 March 2020

1 reference

The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets

31 March 2020

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Players in the PARP-1 cell-death pathway: JNK1 joins the cast.

31 March 2020

1 reference

The clinical development of inhibitors of poly(ADP-ribose) polymerase.

31 March 2020

1 reference

Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?

31 March 2020

1 reference

How to kill tumor cells with inhibitors of poly(ADP-ribosyl)ation.

31 March 2020

1 reference

Harnessing synthetic lethal interactions in anticancer drug discovery

31 March 2020

1 reference

The concept of synthetic lethality in the context of anticancer therapy

31 March 2020

1 reference

The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings

31 March 2020

1 reference

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

31 March 2020

1 reference

Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval

31 March 2020

1 reference

Poly(ADP-ribose) polymerase (PARP) inhibitors: Exploiting a synthetic lethal strategy in the clinic

31 March 2020

1 reference

A snapshot of chemoresistance to PARP inhibitors

31 March 2020

1 reference

Sirtuins mediate mammalian metabolic responses to nutrient availability

31 March 2020

1 reference

The biochemistry of sirtuins.

31 March 2020

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Conserved metabolic regulatory functions of sirtuins

31 March 2020

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

31 March 2020

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Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?

31 March 2020

1 reference

Mammalian sirtuins: biological insights and disease relevance

31 March 2020

1 reference

SIRT1, is it a tumor promoter or tumor suppressor?

31 March 2020

1 reference

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

31 March 2020

1 reference

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

31 March 2020

1 reference

DBC1 is a negative regulator of SIRT1

31 March 2020

1 reference

Negative regulation of the deacetylase SIRT1 by DBC1

31 March 2020

1 reference

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

31 March 2020

1 reference

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

31 March 2020

1 reference

SIRT1: recent lessons from mouse models.

31 March 2020

1 reference

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

1 reference

Deacetylation of p53 modulates its effect on cell growth and apoptosis

31 March 2020

1 reference

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

1 reference

Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

31 March 2020

1 reference

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

31 March 2020

1 reference

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

31 March 2020

1 reference

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

31 March 2020

1 reference

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

31 March 2020

1 reference

Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

31 March 2020

1 reference

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

31 March 2020

1 reference

Chromatin regulation and genome maintenance by mammalian SIRT6

31 March 2020

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SIRT6 promotes DNA repair under stress by activating PARP1

31 March 2020

1 reference

PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation

31 March 2020

1 reference

Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

31 March 2020

1 reference

Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked?

31 March 2020

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SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

31 March 2020

1 reference

Altered sirtuin expression is associated with node-positive breast cancer

31 March 2020

1 reference

Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues

31 March 2020

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"SIRT8" expressed in thyroid cancer is actually SIRT7.

31 March 2020

1 reference

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

31 March 2020

1 reference

31 March 2020

Mitochondrial sirtuins

1 reference

Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition

31 March 2020

1 reference

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources

31 March 2020

1 reference

NAD+ metabolism in health and disease

31 March 2020

1 reference

Pathway analysis of NAD+metabolism

31 March 2020

1 reference

Nicotinamide Phosphoribosyltransferase in Human Diseases

31 March 2020

1 reference

Identification of a novel human nicotinamide mononucleotide adenylyltransferase

31 March 2020

1 reference

Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons

31 March 2020

1 reference

Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1

31 March 2020

1 reference

Regulation of poly(ADP-ribose) polymerase-1-dependent gene expression through promoter-directed recruitment of a nuclear NAD+ synthase

31 March 2020

1 reference

Pathways and subcellular compartmentation of NAD biosynthesis in human cells: from entry of extracellular precursors to mitochondrial NAD generation.

31 March 2020

1 reference

Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and Apoptosis

31 March 2020

1 reference

The dynamic regulation of NAD metabolism in mitochondria

31 March 2020

1 reference

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells

31 March 2020

1 reference

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

31 March 2020

1 reference

Comparative rates of synthesis of diphosphopyridine nucleotide by normal and tumour tissue from mouse mammary gland; studies with isolated nuclei

31 March 2020

1 reference

Enzymic synthesis of coenzyme I in relation to chemical control of cell growth

31 March 2020

1 reference

NMN/NaMN adenylyltransferase (NMNAT) and NAD kinase (NADK) inhibitors: chemistry and potential therapeutic applications

31 March 2020

1 reference

Biochemical mechanisms of resistance to tiazofurin.

31 March 2020

1 reference

Nampt/PBEF/visfatin and cancer

31 March 2020

1 reference

Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2.

31 March 2020

1 reference

Nampt and its potential role in inflammation and type 2 diabetes

31 March 2020

1 reference

The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors

31 March 2020

1 reference

Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials

31 March 2020

1 reference

Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777.

31 March 2020

1 reference

Efficacy of combining GMX1777 with radiation therapy for human head and neck carcinoma

31 March 2020

1 reference

Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound

31 March 2020

1 reference

The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor

31 March 2020

1 reference

Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study

31 March 2020

1 reference

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

31 March 2020

1 reference

NAD depletion by FK866 induces autophagy

31 March 2020

1 reference

Reciprocal potentiation of the antitumoral activities of FK866, an inhibitor of nicotinamide phosphoribosyltransferase, and etoposide or cisplatin in neuroblastoma cells

31 March 2020

1 reference

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

31 March 2020

1 reference

Control of the steady-state concentrations of the nicotinamide nucleotides in rat liver

31 March 2020

1 reference

The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

31 March 2020

1 reference

Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies

31 March 2020

1 reference

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

31 March 2020

1 reference

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

31 March 2020

1 reference

Increased 5-phospho-alpha-D-ribose-1-diphosphate synthetase (ribosephosphate pyrophosphokinase, EC 2.7.6.1) activity in rat hepatomas

31 March 2020

1 reference

12 December 2020

SIRT3 and cancer: tumor promoter or suppressor?

1 reference

12 December 2020

A Phase I study of CHS 828 in patients with solid tumor malignancy

1 reference

12 December 2020

Tiazofurine ICN Pharmaceuticals.

1 reference

12 December 2020

Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates.

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12 December 2020

Poly(ADP-ribose) polymerase: a guardian angel protecting the genome and suppressing tumorigenesis

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12 December 2020

Antiangiogenic potency of FK866/K22.175, a new inhibitor of intracellular NAD biosynthesis, in murine renal cell carcinoma.

1 reference

12 December 2020

FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

1 reference

12 December 2020

CD38 as a therapeutic target

1 reference

12 December 2020

Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects

1 reference

12 December 2020

Clinical toxicity associated with tiazofurin

1 reference

12 December 2020

Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis

1 reference

12 December 2020

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3340

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Dimensions Publication ID

27 August 2017

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