(Q38077741)

28 August 2017

1 reference

title

Flexibility and reactivity in promiscuous enzymes (English)

1 reference

28 August 2017

Pietro Gatti-Lafranconi

object named as

Pietro Gatti-Lafranconi

series ordinal

1

0 references

Florian Hollfelder

object named as

Florian Hollfelder

series ordinal

2

0 references

publication date

29 January 2013

1 reference

28 August 2017

1 reference

28 August 2017

14

1 reference

28 August 2017

285-292

1 reference

28 August 2017

3

1 reference

Benchmark reaction rates, the stability of biological molecules in water, and the evolution of catalytic power in enzymes

28 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Degrees of difficulty of water-consuming reactions in the absence of enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Catalytic promiscuity and the evolution of new enzymatic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzyme recruitment in evolution of new function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzyme promiscuity: a mechanistic and evolutionary perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Binding Affinities of Host–Guest, Protein–Ligand, and Protein–Transition‐State Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Why enzymes are proficient catalysts: beyond the Pauling paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Protein promiscuity and its implications for biotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzymes with extra talents: moonlighting functions and catalytic promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Catalytic promiscuity in biocatalysis: using old enzymes to form new bonds and follow new pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Catalysis by a de novo zinc-mediated protein interface: implications for natural enzyme evolution and rational enzyme engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Cofactor binding and enzymatic activity in an unevolved superfamily of de novo designed 4-helix bundle proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Stereoselective hydrogenation of olefins using rhodium-substituted carbonic anhydrase--a new reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Manganese-substituted carbonic anhydrase as a new peroxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Structural basis for ligand promiscuity in cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Cytochrome P450: taming a wild type enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

A study in molecular contingency: glutamine phosphoribosylpyrophosphate amidotransferase is a promiscuous and evolvable phosphoribosylanthranilate isomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

An efficient, multiply promiscuous hydrolase in the alkaline phosphatase superfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Functional interrelationships in the alkaline phosphatase superfamily: phosphodiesterase activity of Escherichia coli alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Efficient catalytic promiscuity in an enzyme superfamily: an arylsulfatase shows a rate acceleration of 10(13) for phosphate monoester hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Picoliter cell lysate assays in microfluidic droplet compartments for directed enzyme evolution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The time required for water attack at the phosphorus atom of simple phosphodiesters and of DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The rate of hydrolysis of phosphomonoester dianions and the exceptional catalytic proficiencies of protein and inositol phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Biological phosphoryl-transfer reactions: understanding mechanism and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The chemical biology of modular biosynthetic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Natural products version 2.0: connecting genes to molecules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Mapping the limits of substrate specificity of the adenylation domain of TycA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Partition coefficients and their uses

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Redesigning the PheA domain of gramicidin synthetase leads to a new understanding of the enzyme's mechanism and selectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Structural plasticity broadens the specificity of an engineered protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzyme specificity under dynamic control II: Principal component analysis of alpha-lytic protease using global and local solvent boundary conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Einfluss der Configuration auf die Wirkung der Enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Conformational selection or induced fit? A critical appraisal of the kinetic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Conformational selection or induced fit: a flux description of reaction mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzyme dynamics point to stepwise conformational selection in catalysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Application of a Theory of Enzyme Specificity to Protein Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Flexibility, diversity, and cooperativity: pillars of enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Hidden alternative structures of proline isomerase essential for catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Characterization of enzyme motions by solution NMR relaxation dispersion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Antibody multispecificity mediated by conformational diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The role of dynamic conformational ensembles in biomolecular recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Free-energy landscape of enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

"Eppur si muove" (Yet it moves).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Taking Ockham's razor to enzyme dynamics and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzymatic transition states and dynamic motion in barrier crossing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Relating protein motion to catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Protein dynamism and evolvability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Solution structure of a minor and transiently formed state of a T4 lysozyme mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Exploring protein fitness landscapes by directed evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Ultrahigh-throughput FACS-based screening for directed enzyme evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

The potential of microfluidic water-in-oil droplets in experimental biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Microdroplets: a sea of applications?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Microfluidic droplets: new integrated workflows for biological experiments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Single-molecule enzymatic dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Probing single-molecule enzyme active-site conformational state intermittent coherence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Single-biomolecule kinetics: the art of studying a single enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Single-molecule mechanoenzymatics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Chapter 1 Introduction to Polyketide Biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Directed evolution of a gatekeeper domain in nonribosomal peptide synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Enzymes under the nanoscope

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201200628

Mapping catalytic promiscuity in the alkaline phosphatase superfamily

21 January 2018

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC-CON-08-10-20

Identifiers

DOI

10.1002/CBIC.201200628

1 reference

28 August 2017

1 reference

PubMed ID

23362046