(Q38123936)

29 August 2017

title

New insights into pre-BCR and BCR signalling with relevance to B cell malignancies (English)

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29 August 2017

Robert C Rickert

1

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29 August 2017

publication date

1 August 2013

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Nature Reviews Immunology

29 August 2017

published in

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29 August 2017

volume

13

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29 August 2017

issue

8

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29 August 2017

page(s)

578-591

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https://scigraph.springernature.com/pub.10.1038/nri3487

29 August 2017

exact match

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cites work

The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation

1 reference

Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments

31 March 2020

1 reference

Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group

31 March 2020

1 reference

Survival of resting mature B lymphocytes depends on BCR signaling via the Igalpha/beta heterodimer

31 March 2020

1 reference

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death.

31 March 2020

1 reference

Mechanisms of B-cell lymphoma pathogenesis

31 March 2020

1 reference

Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma

31 March 2020

1 reference

AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations

31 March 2020

1 reference

AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development

31 March 2020

1 reference

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

31 March 2020

1 reference

The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

31 March 2020

1 reference

Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

31 March 2020

1 reference

The tipping points in the initiation of B cell signalling: how small changes make big differences.

31 March 2020

1 reference

Integration of B cell responses through Toll-like receptors and antigen receptors

31 March 2020

1 reference

Visualizing a role for the actin cytoskeleton in the regulation of B-cell activation

31 March 2020

1 reference

Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling

31 March 2020

1 reference

The nonimmunoglobulin portion of lambda5 mediates cell-autonomous pre-B cell receptor signaling

31 March 2020

1 reference

BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation

31 March 2020

1 reference

Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells.

31 March 2020

1 reference

Deficiency of the adaptor SLP-65 in pre-B-cell acute lymphoblastic leukaemia

31 March 2020

1 reference

The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion.

31 March 2020

1 reference

BLNK suppresses pre-B-cell leukemogenesis through inhibition of JAK3.

31 March 2020

1 reference

A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation

31 March 2020

1 reference

SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway.

31 March 2020

1 reference

Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

31 March 2020

1 reference

Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

31 March 2020

1 reference

FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.

31 March 2020

1 reference

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.

31 March 2020

1 reference

Bruton's tyrosine kinase cooperates with the B cell linker protein SLP-65 as a tumor suppressor in Pre-B cells.

31 March 2020

1 reference

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion.

31 March 2020

1 reference

Control of B cell development by Ras-mediated activation of Raf.

31 March 2020

1 reference

Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes

31 March 2020

1 reference

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

31 March 2020

1 reference

Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells

31 March 2020

1 reference

The BCR-ABL1 kinase bypasses selection for the expression of a pre-B cell receptor in pre-B acute lymphoblastic leukemia cells

31 March 2020

1 reference

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition

31 March 2020

1 reference

BCL6 is critical for the development of a diverse primary B cell repertoire

31 March 2020

1 reference

The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor

31 March 2020

1 reference

Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling

31 March 2020

1 reference

Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors

31 March 2020

1 reference

IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Ig alpha/beta

31 March 2020

1 reference

The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma.

31 March 2020

1 reference

Molecular characterization of immunoglobulin gene rearrangements in diffuse large B-cell lymphoma: antigen-driven origin and IGHV4-34 as a particular subgroup of the non-GCB subtype.

31 March 2020

1 reference

B-cell receptor signaling in chronic lymphocytic leukemia.

31 March 2020

1 reference

Clonal evolution of a follicular lymphoma: evidence for antigen selection

31 March 2020

1 reference

The B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomas

31 March 2020

1 reference

Surface IgM of CLL cells displays unusual glycans indicative of engagement of antigen in vivo

31 March 2020

1 reference

Human follicular lymphoma cells contain oligomannose glycans in the antigen-binding site of the B-cell receptor.

31 March 2020

1 reference

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling

31 March 2020

1 reference

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

31 March 2020

1 reference

Expression of ZAP-70 is associated with increased B-cell receptor signaling in chronic lymphocytic leukemia

31 March 2020

1 reference

Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis

31 March 2020

1 reference

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells

31 March 2020

1 reference

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

31 March 2020

1 reference

SYK-dependent tonic B-cell receptor signaling is a rational treatment target in diffuse large B-cell lymphoma

31 March 2020

1 reference

B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity.

31 March 2020

1 reference

ITAM-mediated tonic signalling through pre-BCR and BCR complexes

31 March 2020

1 reference

Cutting edge: constitutive B cell receptor signaling is critical for basal growth of B lymphoma

31 March 2020

1 reference

A loss-of-function RNA interference screen for molecular targets in cancer

31 March 2020

1 reference

Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization

31 March 2020

1 reference

Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy

31 March 2020

1 reference

The alternative transcript of CD79b is overexpressed in B-CLL and inhibits signaling for apoptosis

31 March 2020

1 reference

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

1 reference

PI3 kinase signals BCR-dependent mature B cell survival

31 March 2020

1 reference

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase

31 March 2020

1 reference

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

31 March 2020

1 reference

Synergy between PI3K signaling and MYC in Burkitt lymphomagenesis

31 March 2020

1 reference

Integrin signalling adaptors: not only figurants in the cancer story

31 March 2020

1 reference

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

31 March 2020

1 reference

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways

31 March 2020

1 reference

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

31 March 2020

1 reference

Coordinate suppression of B cell lymphoma by PTEN and SHIP phosphatases

31 March 2020

1 reference

Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiation

31 March 2020

1 reference

Cyclin D3 is selectively required for proliferative expansion of germinal center B cells

31 March 2020

1 reference

Requirement for cyclin D3 in germinal center formation and function.

31 March 2020

1 reference

A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice

31 March 2020

1 reference

CD19 is a major B cell receptor-independent activator of MYC-driven B-lymphomagenesis

31 March 2020

1 reference

FOXO1 is a tumor suppressor in classical Hodgkin lymphoma.

31 March 2020

1 reference

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf.

31 March 2020

1 reference

The ARF tumor suppressor: structure, functions and status in cancer

31 March 2020

1 reference

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

31 March 2020

1 reference

Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?

31 March 2020

1 reference

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

31 March 2020

1 reference

Frequent inactivation of A20 in B-cell lymphomas

31 March 2020

1 reference

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

31 March 2020

1 reference

The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.

31 March 2020

1 reference

Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity

31 March 2020

1 reference

Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

31 March 2020

1 reference

Oncogenic CARD11 mutations induce hyperactive signaling by disrupting autoinhibition by the PKC-responsive inhibitory domain

31 March 2020

1 reference

Phosphorylation of the CARMA1 linker controls NF-kappaB activation

31 March 2020

1 reference

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.

31 March 2020

1 reference

Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells

31 March 2020

1 reference

BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas

31 March 2020

1 reference

The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development

31 March 2020

1 reference

Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development

31 March 2020

1 reference

IkappaB kinase signaling is essential for maintenance of mature B cells

31 March 2020

1 reference

IKKβ Is Required for Peripheral B Cell Survival and Proliferation

31 March 2020

1 reference

Immunodeficiency in protein kinase cbeta-deficient mice

31 March 2020

1 reference

Regulation of NF-κB-Dependent Lymphocyte Activation and Development by Paracaspase

31 March 2020

1 reference

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

31 March 2020

1 reference

Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.

31 March 2020

1 reference

NF-κB function in B lymphocytes

31 March 2020

1 reference

Mice lacking the CARD of CARMA1 exhibit defective B lymphocyte development and impaired proliferation of their B and T lymphocytes

31 March 2020

1 reference

PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling

31 March 2020

1 reference

Malignant pirates of the immune system

31 March 2020

1 reference

Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling

31 March 2020

1 reference

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3

31 March 2020

1 reference

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling

31 March 2020

1 reference

Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas.

31 March 2020

1 reference

Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas

31 March 2020

1 reference

Inhibition of the MEK/ERK signaling pathway blocks a subset of B cell responses to antigen

31 March 2020

1 reference

Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

31 March 2020

1 reference

Surface IgM stimulation induces MEK1/2-dependent MYC expression in chronic lymphocytic leukemia cells.

31 March 2020

1 reference

Global gene expression changes of in vitro stimulated human transformed germinal centre B cells as surrogate for oncogenic pathway activation in individual aggressive B cell lymphomas

31 March 2020

1 reference

Map kinase signaling pathways and hematologic malignancies

31 March 2020

1 reference

In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells

31 March 2020

1 reference

MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation.

31 March 2020

1 reference

Mechanisms and clinical significance of BIM phosphorylation in chronic lymphocytic leukemia.

31 March 2020

1 reference

The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma

31 March 2020

1 reference

Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

31 March 2020

1 reference

Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease

31 March 2020

1 reference

The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.

31 March 2020

1 reference

B cell receptor cross-talk: exposure to lipopolysaccharide induces an alternate pathway for B cell receptor-induced ERK phosphorylation and NF-kappa B activation

31 March 2020

1 reference

B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma

31 March 2020

1 reference

B cell receptor (BCR) cross-talk: IL-4 creates an alternate pathway for BCR-induced ERK activation that is phosphatidylinositol 3-kinase independent

31 March 2020

1 reference

Oncogenically active MYD88 mutations in human lymphoma

31 March 2020

1 reference

Regulation of integrin activation through the B-cell receptor

31 March 2020

1 reference

Stromal gene signatures in large-B-cell lymphomas

31 March 2020

1 reference

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

31 March 2020

1 reference

Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation.

31 March 2020

1 reference

PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic

31 March 2020

1 reference

Targeting the microenvironment in chronic lymphocytic leukemia is changing the therapeutic landscape

31 March 2020

1 reference

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

31 March 2020

1 reference

ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia

31 March 2020

1 reference

Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration

31 March 2020

1 reference

Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).

31 March 2020

1 reference

Drug discovery: New Btk inhibitor holds promise.

31 March 2020

1 reference

Cellular origin and pathophysiology of chronic lymphocytic leukemia

31 March 2020

1 reference

PTEN gene alterations in lymphoid neoplasms

31 March 2020

1 reference

12 December 2020

Molecular analysis of immunoglobulin genes in diffuse large B-cell lymphomas.

1 reference

12 December 2020

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.

1 reference

12 December 2020

The tyrosine phosphatase Shp2 in development and cancer

1 reference

12 December 2020

The role of BAFF-R dysregulation in B-lymphoid lineage malignancies

1 reference

12 December 2020

Early steps of follicular lymphoma pathogenesis

1 reference

12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

12 December 2020

An alternatively spliced form of CD79b gene may account for altered B-cell receptor expression in B-chronic lymphocytic leukemia

1 reference

12 December 2020

Lyn tyrosine kinase: accentuating the positive and the negative

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3487

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Dimensions Publication ID

29 August 2017

1008627823

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