(Q38134099)

29 August 2017

2 references

8 February 2021

31 July 2022

Expanding the prion concept to cancer biology: dominant-negative effect of aggregates of mutant p53 tumour suppressor (English)

1 reference

transmissible spongiform encephalopathy

29 August 2017

1 reference

20 December 2019

1 reference

20 December 2019

1 reference

8 February 2021

1

1 reference

29 August 2017

Luciana P Rangel

2

1 reference

29 August 2017

Danielly C F Costa

series ordinal

3

1 reference

29 August 2017

Yraima Cordeiro

series ordinal

4

1 reference

29 August 2017

Claudia V De Moura Gallo

series ordinal

5

1 reference

29 August 2017

language of work or name

1 reference

25 July 2013

11 references

29 August 2017

23 March 2019

3 April 2019

25 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

8 February 2021

31 July 2022

11 references

29 August 2017

23 March 2019

3 April 2019

25 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

8 February 2021

31 July 2022

33

1 reference

29 August 2017

4

1 reference

Creative Commons Attribution 3.0 Unported

29 August 2017

10 references

23 March 2019

3 April 2019

25 April 2019

28 November 2019

11 December 2019

18 December 2019

19 December 2019

20 December 2019

8 February 2021

on focus list of Wikimedia project

31 July 2022

copyright status

copyrighted

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6 September 2017

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Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.

6 September 2017

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6 September 2017

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The clonal and mutational evolution spectrum of primary triple-negative breast cancers

6 September 2017

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Structural features and cytotoxicity of amyloid oligomers: implications in Alzheimer's disease and other diseases with amyloid deposits

6 September 2017

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Atomic View of a Toxic Amyloid Small Oligomer

6 September 2017

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Potential roles for prions and protein-only inheritance in cancer

6 September 2017

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The role of RNA in mammalian prion protein conversion

6 September 2017

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Intermolecular transmission of superoxide dismutase 1 misfolding in living cells

6 September 2017

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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

6 September 2017

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Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance

6 September 2017

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Misfolded protein aggregates: mechanisms, structures and potential for disease transmission

6 September 2017

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The client protein p53 adopts a molten globule-like state in the presence of Hsp90.

6 September 2017

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Hallmarks of Cancer: The Next Generation

6 September 2017

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p53 and its mutants in tumor cell migration and invasion

6 September 2017

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Prion hypothesis: the end of the controversy?

6 September 2017

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PrP interactions with nucleic acids and glycosaminoglycans in function and disease

6 September 2017

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Awakening guardian angels: drugging the p53 pathway

6 September 2017

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The p53 core domain is a molten globule at low pH: functional implications of a partially unfolded structure.

6 September 2017

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Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins

6 September 2017

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30 years and a long way into p53 research

6 September 2017

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In vitro recapitulating of TP53 mutagenesis in hepatocellular carcinoma associated with dietary aflatoxin B1 exposure.

6 September 2017

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Getting a grip on prions: oligomers, amyloids, and pathological membrane interactions

6 September 2017

1 reference

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p53 isoforms - a conspiracy to kidnap p53 tumor suppressor activity?

6 September 2017

1 reference

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Structural biology of the tumor suppressor p53.

6 September 2017

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Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation

6 September 2017

1 reference

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Novel therapeutic strategies for the treatment of protein-misfolding diseases

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

p53 in health and disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Protein misfolding, functional amyloid, and human disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

p53 isoforms can regulate p53 transcriptional activity.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Reversible aggregation plays a crucial role on the folding landscape of p53 core domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Protein aggregation and neurodegenerative disease

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Principles of protein folding, misfolding and aggregation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Conversion of wild-type p53 core domain into a conformation that mimics a hot-spot mutant

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

On the origin of G --> T transversions in lung cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

TP53 and liver carcinogenesis.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Molecular mechanism of the interaction between MDM2 and p53.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Rescuing the function of mutant p53.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

DNA converts cellular prion protein into the beta-sheet conformation and inhibits prion peptide aggregation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

6 September 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

The fundamentals of protein folding: bringing together theory and experiment

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Thermodynamic stability of wild-type and mutant p53 core domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Novel proteinaceous infectious particles cause scrapie

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Time-dependent maturation of the simian virus 40 large T antigen-p53 complex studied by using monoclonal antibodies

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Self-replication and scrapie

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Cancer. p53, guardian of the genome

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Cholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

p73 function is inhibited by tumor-derived p53 mutants in mammalian cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Mutant p53 drives invasion by promoting integrin recycling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Molecular biology. Getting p53 out of the nucleus.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Folding of a cyclin box: linking multitarget binding to marginal stability, oligomerization, and aggregation of the retinoblastoma tumor suppressor AB pocket domain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Cell biology. A unifying role for prions in neurodegenerative diseases

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Transmissible proteins: expanding the prion heresy

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Single-Molecule characterization of oligomerization kinetics and equilibria of the tumor suppressor p53

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

The structure of amyloid fibrils by electron microscopy and X-ray diffraction

23 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

23 June 2018

https://api.crossref.org/works/10.1042%2FBSR20130065

The cellular oncogene p53 can be activated by mutagenesis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Protein-protein interactions in high molecular weight forms of the transformation-related phosphoprotein p53

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Formation of amyloid in human pancreatic islets transplanted to the liver and spleen of nude mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Fibrillar aggregates of the tumor suppressor p53 core domain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Reversible amyloid formation by the p53 tetramerization domain and a cancer-associated mutant

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Cell-free formation of protease-resistant prion protein.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Correlation of metabolic stability and altered quaternary structure of oncoprotein p53 with cell transformation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3728989

Evidence for novel aspects of Nox4 oxidase regulation of mitochondrial function and peroxide generation in an endothelial cell model of senescence.

31 August 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSR20130065

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSR20130065

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSR20130065

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSR20130065

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBSR20130065

p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer

21 January 2018

1 reference

12 December 2020

A comparison between p53 accumulation determined by immunohistochemistry and TP53 mutations as prognostic variables in tumours from breast cancer patients

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12 December 2020

Filling in the blanks in the p53 protein structure

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12 December 2020

Locus-specific mutation databases: pitfalls and good practice based on the p53 experience

1 reference

12 December 2020

Identifiers

DOI

10.1042/BSR20130065

1 reference

29 August 2017

1 reference

29 August 2017

PubMed publication ID

24003888

1 reference