(Q36863389)

16 August 2017

1 reference

title

Novel therapeutic strategies for the treatment of protein-misfolding diseases (English)

1 reference

16 August 2017

Jean-Christophe Rochet

series ordinal

1

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16 August 2017

28 June 2007

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Expert Reviews in Molecular Medicine

16 August 2017

1 reference

16 August 2017

9

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16 August 2017

1-34

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16 August 2017

17

1 reference

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

16 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tau phosphorylation and aggregation in Alzheimer's disease pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Untangling memory deficits.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

C-terminal truncation modulates both nucleation and extension phases of tau fibrillization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Normal huntingtin function: an alternative approach to Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Proteolytic cleavage of polyglutamine-expanded ataxin-3 is critical for aggregation and sequestration of non-expanded ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Caspase-mediated proteolysis of the polyglutamine disease protein ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Somatostatin regulates brain amyloid beta peptide Abeta42 through modulation of proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

PKCepsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Design of potent inhibitors of human beta-secretase. Part 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Gleevec inhibits β-amyloid production but not Notch cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

From rafts to crafts: membrane asymmetry in moving cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Lithium induces autophagy by inhibiting inositol monophosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

mTOR-targeted therapy of cancer with rapamycin derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Rapamycin alleviates toxicity of different aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

APP, Notch, and presenilin: molecular pieces in the puzzle of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tau suppression in a neurodegenerative mouse model improves memory function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Characterization of cytoplasmic alpha-synuclein aggregates. Fibril formation is tightly linked to the inclusion-forming process in cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The crystal structure of transthyretin in complex with diethylstilbestrol: a promising template for the design of amyloid inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Dynein mutations impair autophagic clearance of aggregate-prone proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aggresomes: a cellular response to misfolded proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Protein-protein interactions as targets for small molecule drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Molecular structure of amyloid fibrils: insights from solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Protein-misfolding diseases and chaperone-based therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Protein aggregation and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Mefloquine, an antimalaria drug with antiprion activity in vitro, lacks activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

New inhibitors of scrapie-associated prion protein formation in a library of 2000 drugs and natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Systematic identification of antiprion drugs by high-throughput screening based on scanning for intensely fluorescent targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Up-regulation of heat shock protein 27 induces resistance to 17-allylamino-demethoxygeldanamycin through a glutathione-mediated mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Biologically active molecules that reduce polyglutamine aggregation and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Reversal of a full-length mutant huntingtin neuronal cell phenotype by chemical inhibitors of polyglutamine-mediated aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Toxic proteins in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Glutamine repeats and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Alternative conformations of amyloidogenic proteins govern their behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

JNK mediates pathogenic effects of polyglutamine-expanded androgen receptor on fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Ligand-dependent inhibition and reversal of tau filament formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A high-throughput screen for compounds that inhibit aggregation of the Alzheimer's peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Peptide-based inhibitors of amyloid assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Analysis of alpha-synuclein-associated proteins by quantitative proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Amyloid-like fibrils of ribonuclease A with three-dimensional domain-swapped and native-like structure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Molecular basis for amyloid fibril formation and stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structural organization of alpha-synuclein fibrils studied by site-directed spin labeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Modulation of neurodegeneration by molecular chaperones

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Scanning cysteine mutagenesis analysis of Abeta-(1-40) amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Oxidative stress mediates tau-induced neurodegeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Hydrogen-deuterium (H/D) exchange mapping of Abeta 1-40 amyloid fibril secondary structure using nuclear magnetic resonance spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Huntingtin inclusion bodies are iron-dependent centers of oxidative events.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Mapping abeta amyloid fibril secondary structure using scanning proline mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Analysis of oxidative events induced by expanded polyglutamine huntingtin exon 1 that are differentially restored by expression of heat shock proteins or treatment with an antioxidant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Amyloid fibrillogenesis: themes and variations

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Recent atomic models of amyloid fibril structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate alpha-synuclein fibrilization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Molecular targets and therapeutic strategies in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Identification of rotenone-induced modifications in alpha-synuclein using affinity pull-down and tandem mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Perturbed signal transduction in neurodegenerative disorders involving aberrant protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Methionine oxidation, alpha-synuclein and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Nitration inhibits fibrillation of human α‐synuclein in vitro by formation of soluble oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Acetyl-L-carnitine-induced up-regulation of heat shock proteins protects cortical neurons against amyloid-beta peptide 1-42-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Small molecule inhibitors of alpha-synuclein filament assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Metabolite-initiated protein misfolding may trigger Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A molecular switch in amyloid assembly: Met35 and amyloid beta-protein oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Oxidation of methionine 35 attenuates formation of amyloid beta -peptide 1-40 oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Methionine 35 oxidation reduces fibril assembly of the amyloid abeta-(1-42) peptide of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Neurotoxic, redox-competent Alzheimer's beta-amyloid is released from lipid membrane by methionine oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Vesicle permeabilization by protofibrillar alpha-synuclein: implications for the pathogenesis and treatment of Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tissue damage in the amyloidoses: Transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The most infectious prion protein particles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Opposing activities protect against age-onset proteotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

A specific amyloid-beta protein assembly in the brain impairs memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Protein folding and misfolding

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Transgenic Small Interfering RNA Halts Amyotrophic Lateral Sclerosis in a Mouse Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Interactions with Diverse Intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

Therapeutic approaches to polyglutamine diseases: combating protein misfolding and aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Inhibition of protein misfolding and aggregation by small rationally-designed peptides

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Structural differences in Abeta amyloid protofibrils and fibrils mapped by hydrogen exchange--mass spectrometry with on-line proteolytic fragmentation

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Developing therapeutics for the diseases of protein misfolding

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

alpha-Synuclein is phosphorylated in synucleinopathy lesions

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

GSK-3 is essential in the pathogenesis of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Chemical and pharmacological chaperones as new therapeutic agents

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Acylguanidines as small-molecule beta-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

HSP27 but not HSP70 has a potent protective effect against alpha-synuclein-induced cell death in mammalian neuronal cells.

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Metal-catalyzed oxidation of alpha-synuclein: helping to define the relationship between oligomers, protofibrils, and filaments

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice--a model of familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1017%2FS1462399407000385

7 January 2021

10.1017/S1462399407000385

Identifiers

DOI

0 references

PubMed ID

17597554

1 reference

PubMed ID

17597554