(Q38207394)

31 August 2017

title

Role of epigenetic mechanisms in epithelial-to-mesenchymal transition of breast cancer cells (English)

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31 August 2017

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Annina Nickel

1

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31 August 2017

Sonja C Stadler

series ordinal

2

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31 August 2017

publication date

12 April 2014

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31 August 2017

published in

Translational Research

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31 August 2017

volume

165

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31 August 2017

issue

1

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31 August 2017

page(s)

126-142

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Breast cancer statistics, 2011.

31 August 2017

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A Twist in fate: evolutionary comparison of Twist structure and function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Correlation of Snail expression with histological grade and lymph node status in breast carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Snail and slug play distinct roles during breast carcinoma progression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

The transcriptional repressor Snail promotes mammary tumor recurrence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Evidence for a function of CtBP in epithelial gene regulation and anoikis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Coordinated histone modifications mediated by a CtBP co-repressor complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Another Tie that Binds the MTA Family to Breast Cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Dysregulation of PAD4-mediated citrullination of nuclear GSK3β activates TGF-β signaling and induces epithelial-to-mesenchymal transition in breast cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Polycomb group protein complexes: do different complexes regulate distinct target genes?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Epithelial mesenchymal transition traits in human breast cancer cell lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A case study in cross-talk: the histone lysine methyltransferases G9a and GLP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

SET8 promotes epithelial-mesenchymal transition and confers TWIST dual transcriptional activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

CoREST is an integral component of the CoREST- human histone deacetylase complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

LSD1 demethylates histone and non-histone proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

The loss of estrogen and progesterone receptor gene expression in human breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

CDH1 promoter hypermethylation and E-cadherin protein expression in infiltrating breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Expression and functional significance of HtrA1 loss in endometrial cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Downregulation of serine protease HTRA1 is associated with poor survival in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

RNA-Seq of human breast ductal carcinoma in situ models reveals aldehyde dehydrogenase isoform 5A1 as a novel potential target

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MicroRNAs as regulators of epithelial-mesenchymal transition.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

p53 represses c-Myc through induction of the tumor suppressor miR-145

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A microRNA DNA methylation signature for human cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

A MicroRNA targeting dicer for metastasis control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

MicroRNA-21 regulates breast cancer invasion partly by targeting tissue inhibitor of metalloproteinase 3 expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Epigenetic modifications as therapeutic targets

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Epigenetic therapy of cancer: past, present and future

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Approval summary: azacitidine for treatment of myelodysplastic syndrome subtypes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Phase II multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Selective inhibition of BET bromodomains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Targeting MYC dependence in cancer by inhibiting BET bromodomains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Differentiation of NUT midline carcinoma by epigenomic reprogramming

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Breast cancer and microRNAs: therapeutic impact.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2014.04.001

10.1016/J.TRSL.2014.04.001

7 January 2021

Identifiers

DOI

1 reference

31 August 2017

1 reference