(Q38218971)

31 August 2017

title

The mechanistic role of DNA methylation in myeloid leukemogenesis (English)

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31 August 2017

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J Jasielec

1

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31 August 2017

V Saloura

series ordinal

2

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31 August 2017

L A Godley

series ordinal

3

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31 August 2017

publication date

20 May 2014

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31 August 2017

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31 August 2017

volume

28

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31 August 2017

issue

9

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31 August 2017

page(s)

1765-1773

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https://scigraph.springernature.com/pub.10.1038/leu.2014.163

31 August 2017

exact match

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cites work

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Chromatin proteins and modifications as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Recent progress toward epigenetic therapies: the example of mixed lineage leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Amount and distribution of 5-methylcytosine in human DNA from different types of tissues of cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Dissecting DNA hypermethylation in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

DNA methylation patterns and epigenetic memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Advances in understanding the coupling of DNA base modifying enzymes to processes involving base excision repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Epigenetic reprogramming: is deamination key to active DNA demethylation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

5-Methylcytosine DNA demethylation: more than losing a methyl group

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Alterations of 5-hydroxymethylcytosine in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Clinical response and miR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Guided by RNAs: X-inactivation as a model for lncRNA function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Xist RNA is a potent suppressor of hematologic cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Long intergenic noncoding RNA HOTAIR is overexpressed and regulates PTEN methylation in laryngeal squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Association of large noncoding RNA HOTAIR expression and its downstream intergenic CpG island methylation with survival in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Array-based genomic resequencing of human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

De novo DNA methylation by Dnmt3a and Dnmt3b is dispensable for nuclear reprogramming of somatic cells to a pluripotent state

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

The prognostic significance of IDH2 mutations in AML depends on the location of the mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

TET2 mutations improve the new European LeukemiaNet risk classification of acute myeloid leukemia: a Cancer and Leukemia Group B study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Dnmt3a is essential for hematopoietic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Large conserved domains of low DNA methylation maintained by Dnmt3a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

5-azacitidine prolongs overall survival in patients with myelodysplastic syndrome--a systematic review and meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

The human equilibrative nucleoside transporter 1 mediates in vitro cytarabine sensitivity in childhood acute myeloid leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Membrane transporters and channels: role of the transportome in cancer chemosensitivity and chemoresistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Cellular differentiation, cytidine analogs and DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Novel Insights into the Molecular Mechanism of Action of DNA Hypomethylating Agents: Role of Protein Kinase C δ in Decitabine-Induced Degradation of DNA Methyltransferase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Multiple new phenotypes induced in and 3T3 cells treated with 5-azacytidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Azacytidine causes complex DNA methylation responses in myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Genomic impact of transient low-dose decitabine treatment on primary AML cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

DNA methylation and microRNA dysregulation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Genome-wide epigenetic regulation of miRNAs in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Drug effects on nucleic acid modification. I. A specific effect of 5-azacytidine on mammalian transfer RNA methylation invivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

TET2 is essential for survival and hematopoietic stem cell homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2014.163

Effects of 5-azacytidine on transfer RNA methyltransferases

21 January 2018

1 reference

12 December 2020

Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia

1 reference

12 December 2020

DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia

1 reference

12 December 2020

Uncovering the role of 5-hydroxymethylcytosine in the epigenome

1 reference

12 December 2020

Isocitrate dehydrogenase (IDH)2 R140Q mutation induces myeloid and lymphoid neoplasms in mice.

1 reference

12 December 2020

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia

1 reference

12 December 2020

Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia

1 reference

12 December 2020

Identifiers

DOI

10.1038/LEU.2014.163

1 reference

Dimensions Publication ID

31 August 2017

1006767626

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1 reference