(Q38237431)

31 August 2017

title

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression (English)

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31 August 2017

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3

Zachary T Schafer

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31 August 2017

Cassandra L Buchheit

1

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31 August 2017

Kelsey J Weigel

series ordinal

2

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31 August 2017

language of work or name

English

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publication date

7 August 2014

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31 August 2017

published in

Nature Reviews Cancer

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31 August 2017

volume

14

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31 August 2017

issue

9

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31 August 2017

page(s)

632-641

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https://scigraph.springernature.com/pub.10.1038/nrc3789

31 August 2017

exact match

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cites work

Unravelling the complexity of metastasis - molecular understanding and targeted therapies

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Hallmarks of Cancer: The Next Generation

31 March 2020

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Genetic determinants of cancer metastasis

31 March 2020

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Metastasis: a question of life or death

31 March 2020

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31 March 2020

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Anoikis resistance and tumor metastasis

31 March 2020

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The regulation of cancer cell death and metabolism by extracellular matrix attachment

31 March 2020

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The discovery of receptor tyrosine kinases: targets for cancer therapy

31 March 2020

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The insulin and insulin-like growth factor receptor family in neoplasia: an update

31 March 2020

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The insulin-like growth factor I receptor is required for Akt activation and suppression of anoikis in cells transformed by the ETV6-NTRK3 chimeric tyrosine kinase.

31 March 2020

1 reference

PTK6 Regulates IGF-1-Induced Anchorage-Independent Survival

31 March 2020

1 reference

The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.

31 March 2020

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Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

31 March 2020

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Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes.

31 March 2020

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ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells

31 March 2020

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ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells

31 March 2020

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Intracellular reactive oxygen species activate Src tyrosine kinase during cell adhesion and anchorage-dependent cell growth

31 March 2020

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Phosphorylation of Y845 on the epidermal growth factor receptor mediates binding to the mitochondrial protein cytochrome c oxidase subunit II.

31 March 2020

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Redox regulation of anoikis: reactive oxygen species as essential mediators of cell survival.

31 March 2020

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Redox regulation of anoikis resistance of metastatic prostate cancer cells: key role for Src and EGFR-mediated pro-survival signals

31 March 2020

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Angiopoietin-like 4 protein elevates the prosurvival intracellular O2(-):H2O2 ratio and confers anoikis resistance to tumors

31 March 2020

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

31 March 2020

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Hypoxia suppression of Bim and Bmf blocks anoikis and luminal clearing during mammary morphogenesis

31 March 2020

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The oncogene HER2/neu (ERBB2) requires the hypoxia-inducible factor HIF-1 for mammary tumor growth and anoikis resistance

31 March 2020

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Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

31 March 2020

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RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

31 March 2020

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Cell cycle arrest or survival signaling through αv integrins, activation of PKC and ERK1/2 lead to anoikis resistance of ovarian cancer spheroids.

31 March 2020

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The integrin-linked kinase (ILK) suppresses anoikis

31 March 2020

1 reference

CAF-secreted IGFBPs regulate breast cancer cell anoikis.

31 March 2020

1 reference

Targeting RAS signalling pathways in cancer therapy

31 March 2020

1 reference

Disruption of epithelial cell-matrix interactions induces apoptosis

31 March 2020

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Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

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Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling

31 March 2020

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Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells

31 March 2020

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Oncogenic ras-induced down-regulation of pro-apoptotic protease caspase-2 is required for malignant transformation of intestinal epithelial cells

31 March 2020

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Oncogenic Ras blocks anoikis by activation of a novel effector pathway independent of phosphatidylinositol 3-kinase

31 March 2020

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Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis

31 March 2020

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The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal

31 March 2020

1 reference

Oncogenic B-RAFV600E Promotes Anchorage-Independent Survival of Human Melanocytes

31 March 2020

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Role of Bim in the survival pathway induced by Raf in epithelial cells

31 March 2020

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Mutations of the BRAF gene in human cancer

31 March 2020

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B-RAF and PI-3 kinase signaling protect melanoma cells from anoikis

31 March 2020

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Mutant B-RAF mediates resistance to anoikis via Bad and Bim.

31 March 2020

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Mcl-1 is required for melanoma cell resistance to anoikis

31 March 2020

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Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor

31 March 2020

1 reference

31 March 2020

RHO-GTPases and cancer

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Resensitization of breast cancer cells to anoikis by tropomyosin-1: role of Rho kinase-dependent cytoskeleton and adhesion

31 March 2020

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p66Shc mediates anoikis through RhoA

31 March 2020

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Aiolos promotes anchorage independence by silencing p66Shc transcription in cancer cells

31 March 2020

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p66Shc restrains Ras hyperactivation and suppresses metastatic behavior

31 March 2020

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Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis

31 March 2020

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Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis

31 March 2020

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Akt and RhoA inhibition promotes anoikis of aggregated B16F10 melanoma cells.

31 March 2020

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RhoG regulates anoikis through a phosphatidylinositol 3-kinase-dependent mechanism

31 March 2020

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Ephexin4 and EphA2 mediate resistance to anoikis through RhoG and phosphatidylinositol 3-kinase.

31 March 2020

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Mechanisms that link the oncogenic epithelial-mesenchymal transition to suppression of anoikis

31 March 2020

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Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.

31 March 2020

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Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways

31 March 2020

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A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition

31 March 2020

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Loss of p120-catenin induces metastatic progression of breast cancer by inducing anoikis resistance and augmenting growth factor receptor signaling

31 March 2020

1 reference

Retracted: Epithelial Mesenchymal Transition Is Required for Acquisition of Anoikis Resistance and Metastatic Potential in Adenoid Cystic Carcinoma

31 March 2020

1 reference

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

31 March 2020

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Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis

31 March 2020

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A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis

31 March 2020

1 reference

DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition

31 March 2020

1 reference

Deconvoluting the context-dependent role for autophagy in cancer

31 March 2020

1 reference

Autophagy in cell death: an innocent convict?

31 March 2020

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

31 March 2020

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Induction of autophagy during extracellular matrix detachment promotes cell survival

31 March 2020

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PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment

31 March 2020

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Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK

31 March 2020

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IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway

31 March 2020

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Metabolic stress in autophagy and cell death pathways

31 March 2020

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Metabolic catastrophe as a means to cancer cell death

31 March 2020

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Regulation of cancer cell metabolism

31 March 2020

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The engine driving the ship: metabolic steering of cell proliferation and death.

31 March 2020

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Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress

31 March 2020

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Antioxidant enzymes mediate survival of breast cancer cells deprived of extracellular matrix.

31 March 2020

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Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

31 March 2020

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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

31 March 2020

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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

31 March 2020

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A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion.

31 March 2020

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Regulation of myosin activation during cell-cell contact formation by Par3-Lgl antagonism: entosis without matrix detachment

31 March 2020

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Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death

31 March 2020

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Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells

31 March 2020

1 reference

The cell biology of cell-in-cell structures

31 March 2020

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Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

31 March 2020

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mTOR regulates phagosome and entotic vacuole fission.

31 March 2020

1 reference

Treatment of HER2-positive breast cancer: current status and future perspectives.

31 March 2020

1 reference

ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini

31 March 2020

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Modelling glandular epithelial cancers in three-dimensional cultures

31 March 2020

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BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms

31 March 2020

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G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression

31 March 2020

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Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes

31 March 2020

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An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism

31 March 2020

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Transforming growth factor-alpha prevents detachment-induced inhibition of c-Src kinase activity, Bcl-XL down-regulation, and apoptosis of intestinal epithelial cells

31 March 2020

1 reference

Increased Bcl-xL expression mediates v-Src-induced resistance to anoikis in intestinal epithelial cells

31 March 2020

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Cell detachment triggers p38 mitogen-activated protein kinase-dependent overexpression of Fas ligand. A novel mechanism of Anoikis of intestinal epithelial cells

31 March 2020

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Apoptosis commitment and activation of mitochondrial Bax during anoikis is regulated by p38MAPK.

31 March 2020

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Control of adhesion-dependent cell survival by focal adhesion kinase

31 March 2020

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Focal adhesion kinase gene silencing promotes anoikis and suppresses metastasis of human pancreatic adenocarcinoma cells

31 March 2020

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An altered fibronectin matrix induces anoikis of human squamous cell carcinoma cells by suppressing integrin alpha v levels and phosphorylation of FAK and ERK.

31 March 2020

1 reference

Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: fibronectin and integrin alphav mediate survival signals through focal adhesion kinase

31 March 2020

1 reference

Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance

31 March 2020

1 reference

FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas

31 March 2020

1 reference

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.

31 March 2020

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Src activation regulates anoikis in human colon tumor cell lines

31 March 2020

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Altered regulation of Src upon cell detachment protects human lung adenocarcinoma cells from anoikis

31 March 2020

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Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.

31 March 2020

1 reference

Atypical protein kinase Cι (PKCι) promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to Anoikis via PKCι-SKP2-AKT pathway

31 March 2020

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FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance

31 March 2020

1 reference

p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms

31 March 2020

1 reference

Downregulation of the pro-apoptotic protein Bak is required for the ras-induced transformation of intestinal epithelial cells.

31 March 2020

1 reference

Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm

31 March 2020

1 reference

ras Oncogene triggers up-regulation of cIAP2 and XIAP in intestinal epithelial cells: epidermal growth factor receptor-dependent and -independent mechanisms of ras-induced transformation.

31 March 2020

1 reference

Analysis of the transcriptional program induced by Raf in epithelial cells

31 March 2020

1 reference

Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis

31 March 2020

1 reference

EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation

31 March 2020

1 reference

Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance

31 March 2020

1 reference

ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion

31 March 2020

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Rac1 protects epithelial cells against anoikis

31 March 2020

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Regulation of anoikis by Cdc42 and Rac1.

31 March 2020

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MicroRNA-200a promotes anoikis resistance and metastasis by targeting YAP1 in human breast cancer

31 March 2020

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Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP.

31 March 2020

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Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

31 March 2020

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vFLIP from KSHV inhibits anoikis of primary endothelial cells

31 March 2020

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Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1.

31 March 2020

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IAP regulation of metastasis

31 March 2020

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Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-κB.

31 March 2020

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Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

31 March 2020

1 reference

Zeb1 is required for TrkB-induced epithelial-mesenchymal transition, anoikis resistance and metastasis

31 March 2020

1 reference

Targets of miR-200c mediate suppression of cell motility and anoikis resistance

31 March 2020

1 reference

miR-200c targets a NF-κB up-regulated TrkB/NTF3 autocrine signaling loop to enhance anoikis sensitivity in triple negative breast cancer

31 March 2020

1 reference

A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition

31 March 2020

1 reference

A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

31 March 2020

1 reference

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

31 March 2020

1 reference

Regulation of the microRNA 200b (miRNA-200b) by transcriptional regulators PEA3 and ELK-1 protein affects expression of Pin1 protein to control anoikis

31 March 2020

1 reference

Smad7 inhibits the survival nuclear factor kappaB and potentiates apoptosis in epithelial cells

31 March 2020

1 reference

Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts

31 March 2020

1 reference

TGF-β upregulates miR-181a expression to promote breast cancer metastasis

31 March 2020

1 reference

Insulin-like growth factor-I-mediated survival from anoikis: role of cell aggregation and focal adhesion kinase

31 March 2020

1 reference

12 December 2020

Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect

1 reference

12 December 2020

Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor

1 reference

12 December 2020

BimEL is an important determinant for induction of anoikis sensitivity by mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitors.

1 reference

12 December 2020

Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis

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12 December 2020

p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis.

1 reference

12 December 2020

Inhibition of integrin-linked kinase (ILK) suppresses activation of protein kinase B/Akt and induces cell cycle arrest and apoptosis of PTEN-mutant prostate cancer cells

1 reference

12 December 2020

A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.

1 reference

12 December 2020

U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC3789

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Dimensions Publication ID

31 August 2017

1046357606

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