(Q38260253)

1 September 2017

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title

The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins? (English)

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1 September 2017

3

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1 September 2017

Andrea Scelfo

1

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1 September 2017

Andrea Piunti

series ordinal

2

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1 September 2017

language of work or name

English

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publication date

11 November 2014

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1 September 2017

number of pages

20

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based on heuristic

inferred from page(s)

published in

FEBS Journal

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1 September 2017

volume

282

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1 September 2017

issue

9

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1 September 2017

page(s)

1703-1722

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A gene complex controlling segmentation in Drosophila

1 September 2017

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Epigenetic factors in cancer development: polycomb group proteins

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A new world of Polycombs: unexpected partnerships and emerging functions

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PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes

21 January 2018

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Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation

21 January 2018

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Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

21 January 2018

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The Polycomb complex PRC2 and its mark in life

21 January 2018

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Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity

21 January 2018

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Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing

21 January 2018

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A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin

21 January 2018

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Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity

21 January 2018

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SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of histone H3 lysine 27 methylation in Polycomb-group silencing

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

21 January 2018

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Chromatin repressive complexes in stem cells, development, and cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb protein Ezh1 promotes RNA polymerase II elongation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb silencers control cell fate, development and cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FFEBS.13112

Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The polycomb-group gene Ezh2 is required for early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb complexes repress developmental regulators in murine embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of the polycomb protein EED in the propagation of repressive histone marks

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A model for transmission of the H3K27me3 epigenetic mark

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Long residence time inhibition of EZH2 in activated polycomb repressive complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of hPHF1 in H3K27 methylation and Hox gene silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

PRC2 complexes with JARID2, MTF2, and esPRC2p48 in ES cells to modulate ES cell pluripotency and somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A novel human homologue of Drosophila polycomblike gene is up-regulated in multiple cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Jarid2 and PRC2, partners in regulating gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The central role of EED in the orchestration of polycomb group complexes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of histone H2A ubiquitination in Polycomb silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb complex recruitment in pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

CpG islands recruit a histone H3 lysine 36 demethylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

WDR5, a complexed protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Physiological roles of class I HDAC complex and histone demethylase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Dogma derailed: the many influences of RNA on the genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Tsix, a gene antisense to Xist at the X-inactivation centre

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Long noncoding RNA as modular scaffold of histone modification complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Structural and functional differences in the long non-coding RNA hotair in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genome-wide identification of polycomb-associated RNAs by RIP-seq

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Promiscuous RNA binding by Polycomb repressive complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Interactions between JARID2 and noncoding RNAs regulate PRC2 recruitment to chromatin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

General transcriptional silencing by a Polycomb response element in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genome-wide analysis of Polycomb targets in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genome-wide analysis of promoter architecture in Drosophila melanogaster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

REST-mediated recruitment of polycomb repressor complexes in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of the polycomb repressive complex 2 in acute promyelocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Division of labor in polycomb group repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb-dependent regulatory contacts between distant Hox loci in Drosophila.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Reconstitution of a functional core polycomb repressive complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

General transcription factors bind promoters repressed by Polycomb group proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Core transcriptional regulatory circuitry in human embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb function during oogenesis is required for mouse embryonic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

CBX7 is a tumor suppressor in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb group proteins: navigators of lineage pathways led astray in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomblike-2-deficient mice exhibit normal left-right asymmetry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

RYBP represses endogenous retroviruses and preimplantation- and germ line-specific genes in mouse embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Male-to-female sex reversal in M33 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Random replication of the inactive X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Posterior transformation, neurological abnormalities, and severe hematopoietic defects in mice with a targeted deletion of the bmi-1 proto-oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb repressive complex 2 regulates normal hematopoietic stem cell function in a developmental-stage-specific manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Chromatin proteins and modifications as drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Chromatin targeting drugs in cancer and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Tumor suppressor function of the polycomb group genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A complex Polycomb issue: the two faces of EZH2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH2 in normal and malignant hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The role of histone methyltransferase EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb CBX7 has a unifying role in cellular lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Role of the chromobox protein CBX7 in lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH2 couples pancreatic regeneration to neoplastic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The INK4a/ARF locus in murine tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Clinical significance of Polycomb gene expression in brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

BMI1 sustains human glioblastoma multiforme stem cell renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

EZH2 is essential for glioblastoma cancer stem cell maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FFEBS.13112

21 January 2018

Identifiers

DOI

10.1111/FEBS.13112

1 reference

1 September 2017

1 reference