(Q38495049)

3 September 2017

1 reference

title

Schistosome sirtuins as drug targets (English)

1 reference

3 September 2017

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Alejandro Cabezas-Cruz

2

1 reference

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12 June 2020

Stéphanie Caby

3

1 reference

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12 June 2020

Martin Marek

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Christophe Romier

6

1 reference

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12 June 2020

Manfred Jung

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

author name string

Julien Lancelot

1

1 reference

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12 June 2020

Johan Schultz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

Raymond J Pierce

9

1 reference

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12 June 2020

publication date

1 January 2015

1 reference

Future Medicinal Chemistry

3 September 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

page(s)

765-782

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25996069%20AND%20SRC:MED&resulttype=core&format=json

The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008.

12 June 2020

cites work

1 reference

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

21 January 2018

1 reference

The genome of the blood fluke Schistosoma mansoni

21 January 2018

1 reference

The Schistosoma japonicum genome reveals features of host-parasite interplay

21 January 2018

1 reference

Whole-genome sequence of Schistosoma haematobium

21 January 2018

1 reference

Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

21 January 2018

1 reference

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

21 January 2018

1 reference

Lessons on longevity from budding yeast

21 January 2018

1 reference

Metabolic and neuropsychiatric effects of calorie restriction and sirtuins

21 January 2018

1 reference

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

21 January 2018

1 reference

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

21 January 2018

1 reference

Sirtuins of parasitic protozoa: in search of function(s).

21 January 2018

1 reference

Sirtuins as emerging anti-parasitic targets

21 January 2018

1 reference

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

21 January 2018

1 reference

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

1 reference

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

21 January 2018

1 reference

Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis

21 January 2018

1 reference

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

21 January 2018

1 reference

SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress

21 January 2018

1 reference

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

21 January 2018

1 reference

New and continuing developments at PROSITE.

21 January 2018

1 reference

Sirtuins, metabolism, and DNA repair

21 January 2018

1 reference

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

A therapeutic role for sirtuins in diseases of aging?

21 January 2018

1 reference

Calorie restriction and sirtuins revisited

21 January 2018

1 reference

NAD+ as a signaling molecule modulating metabolism

21 January 2018

1 reference

How does SIRT1 affect metabolism, senescence and cancer?

21 January 2018

1 reference

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

21 January 2018

1 reference

SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient- and exercise-induced stress.

21 January 2018

1 reference

Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation

21 January 2018

1 reference

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

21 January 2018

1 reference

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

21 January 2018

1 reference

On the Origin of Cancer Cells

21 January 2018

1 reference

The reversible effect of glucose on the energy metabolism of Schistosoma mansoni cercariae and schistosomula

21 January 2018

1 reference

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

21 January 2018

1 reference

SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

21 January 2018

1 reference

SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

21 January 2018

1 reference

A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

21 January 2018

1 reference

Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1

21 January 2018

1 reference

Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation.

21 January 2018

1 reference

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

21 January 2018

1 reference

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

21 January 2018

1 reference

ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair

21 January 2018

1 reference

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

21 January 2018

1 reference

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

21 January 2018

1 reference

SIRT3 functions in the nucleus in the control of stress-related gene expression

21 January 2018

1 reference

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

21 January 2018

1 reference

Structure of the histone deacetylase SIRT2

21 January 2018

1 reference

Crystal structures of human SIRT3 displaying substrate-induced conformational changes

21 January 2018

1 reference

Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

21 January 2018

1 reference

Structure and biochemical functions of SIRT6.

21 January 2018

1 reference

The 2.5 Å crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition

21 January 2018

1 reference

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

21 January 2018

1 reference

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

21 January 2018

1 reference

Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

21 January 2018

1 reference

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

21 January 2018

1 reference

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

21 January 2018

1 reference

Sorting out functions of sirtuins in cancer

21 January 2018

1 reference

Emerging Roles of SIRT1 in Cancer Drug Resistance

21 January 2018

1 reference

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

21 January 2018

1 reference

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

21 January 2018

1 reference

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

21 January 2018

1 reference

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

21 January 2018

1 reference

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

21 January 2018

1 reference

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

21 January 2018

1 reference

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

21 January 2018

1 reference

Epigenetic protein families: a new frontier for drug discovery

21 January 2018

1 reference

New assays and approaches for discovery and design of Sirtuin modulators

21 January 2018

1 reference

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

21 January 2018

1 reference

Inhibitors of NAD+ dependent histone deacetylases (sirtuins).

21 January 2018

1 reference

Sirtuins inhibitors: the approach to affinity and selectivity

21 January 2018

1 reference

Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry

21 January 2018

1 reference

Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation

21 January 2018

1 reference

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

21 January 2018

1 reference

Identification and characterization of novel sirtuin inhibitor scaffolds

21 January 2018

1 reference

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

21 January 2018

1 reference

Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.

21 January 2018

1 reference

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing

21 January 2018

1 reference

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

1 reference

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

21 January 2018

1 reference

Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach

21 January 2018

1 reference

Identification of Selective Inhibitors of NAD+-dependent Deacetylases Using Phenotypic Screens in Yeast

21 January 2018

1 reference

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

21 January 2018

1 reference

N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.

21 January 2018

1 reference

Inhibition of the human deacylase Sirtuin 5 by the indole GW5074.

21 January 2018

1 reference

Chemical probing of the human sirtuin 5 active site reveals its substrate acyl specificity and peptide-based inhibitors

21 January 2018

1 reference

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5

21 January 2018

1 reference

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3

21 January 2018

1 reference

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

21 January 2018

1 reference

Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum

21 January 2018

1 reference

Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum

21 January 2018

1 reference

Targeted disruption of cytosolic SIR2 deacetylase discloses its essential role in Leishmania survival and proliferation.

21 January 2018

1 reference

Stage-specific antileishmanial activity of an inhibitor of SIR2 histone deacetylase.

21 January 2018

1 reference

Bisnaphthalimidopropyl derivatives as inhibitors of Leishmania SIR2 related protein 1.

21 January 2018

1 reference