(Q38568755)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Mechanism, factors, and physiological role of nonsense-mediated mRNA decay (English)

1 reference

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22 February 2020

2

1 reference

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22 February 2020

Niels H Gehring

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

author name string

Tobias Fatscher

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

publication date

18 August 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

Cellular and Molecular Life Sciences

22 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

volume

72

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

issue

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

page(s)

4523-4544

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00018-015-2017-9

22 February 2020

exact match

0 references

cites work

Nonsense-mediated mRNA decay (NMD) mechanisms

1 reference

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The interaction of cytoplasmic poly(A)-binding protein with eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay

21 January 2018

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Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

21 January 2018

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Eukaryotic initiation factor 4G suppresses nonsense-mediated mRNA decay by two genetically separable mechanisms

21 January 2018

1 reference

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A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay

21 January 2018

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The effect of eukaryotic release factor depletion on translation termination in human cell lines

21 January 2018

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Involvement of human release factors eRF3a and eRF3b in translation termination and regulation of the termination complex formation

21 January 2018

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Molecular cloning of a novel member of the eukaryotic polypeptide chain-releasing factors (eRF). Its identification as eRF3 interacting with eRF1

21 January 2018

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The polypeptide chain release factor eRF1 specifically contacts the s(4)UGA stop codon located in the A site of eukaryotic ribosomes

21 January 2018

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A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

21 January 2018

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Mutations in the highly conserved GGQ motif of class 1 polypeptide release factors abolish ability of human eRF1 to trigger peptidyl-tRNA hydrolysis.

21 January 2018

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The crystal structure of human eukaryotic release factor eRF1--mechanism of stop codon recognition and peptidyl-tRNA hydrolysis

21 January 2018

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GTP hydrolysis by eRF3 facilitates stop codon decoding during eukaryotic translation termination

21 January 2018

1 reference

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In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3

21 January 2018

1 reference

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The role of ABCE1 in eukaryotic posttermination ribosomal recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Ribosome recycling depends on a mechanistic link between the FeS cluster domain and a conformational switch of the twin-ATPase ABCE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural basis of highly conserved ribosome recycling in eukaryotes and archaea

21 January 2018

1 reference

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A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: domain structure and expression

21 January 2018

1 reference

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Recognition of polyadenylate RNA by the poly(A)-binding protein

21 January 2018

1 reference

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Poly(A)-binding protein and eRF3 are associated in vivo in human and Xenopus cells

21 January 2018

1 reference

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Structure and function of the C-terminal PABC domain of human poly(A)-binding protein

21 January 2018

1 reference

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The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Molecular basis of eRF3 recognition by the MLLE domain of poly(A)-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Interdomain allostery promotes assembly of the poly(A) mRNA complex with PABP and eIF4G

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Translation factors promote the formation of two states of the closed-loop mRNP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Circularization of mRNA by eukaryotic translation initiation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Binary specification of nonsense codons by splicing and cytoplasmic translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Boundary-independent polar nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The human intronless melanocortin 4-receptor gene is NMD insensitive

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Disassembly of exon junction complexes by PYM

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Role of the nonsense-mediated decay factor hUpf3 in the splicing-dependent exon-exon junction complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Y14 and hUpf3b form an NMD-activating complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3' UTR length.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

3' UTR length and messenger ribonucleoprotein composition determine endocleavage efficiencies at termination codons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification of elements in human long 3' UTRs that inhibit nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Global analyses of UPF1 binding and function reveal expanded scope of nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Rules that govern UPF1 binding to mRNA 3' UTRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Translation-dependent displacement of UPF1 from coding sequences causes its enrichment in 3' UTRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Evidence for a pioneer round of mRNA translation: mRNAs subject to nonsense-mediated decay in mammalian cells are bound by CBP80 and CBP20

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

eIF4E-bound mRNPs are substrates for nonsense-mediated mRNA decay in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense mutations in the human beta-globin gene affect mRNA metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Two cloned β thalassemia genes are associated with amber mutations at codon 39

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Autoregulation of the nonsense-mediated mRNA decay pathway in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Posttranscriptional gene regulation by spatial rearrangement of the 3' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Tissue-specific regulation of selenoenzyme gene expression during selenium deficiency in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Selenium regulation of thioredoxin reductase activity and mRNA levels in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated decay factors are involved in the regulation of selenoprotein mRNA levels during selenium deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

EST comparison indicates 38% of human mRNAs contain possible alternative splice forms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The RNA degradation pathway regulates the function of GAS5 a non-coding RNA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Ribosome profiling reveals resemblance between long non-coding RNAs and 5' leaders of coding RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Gene products that promote mRNA turnover in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Looking at mRNA decay pathways through the window of molecular evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Crystal structure of the UPF2-interacting domain of nonsense-mediated mRNA decay factor UPF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Molecular identification of smg-4, required for mRNA surveillance in C. elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification and characterization of novel factors that act in the nonsense-mediated mRNA decay pathway in nematodes, flies and mammals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

MOV10 Is a 5' to 3' RNA helicase contributing to UPF1 mRNA target degradation by translocation along 3' UTRs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Aberrant growth and lethality of Arabidopsis deficient in nonsense-mediated RNA decay factors is caused by autoimmune-like response

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Rent1, a trans-effector of nonsense-mediated mRNA decay, is essential for mammalian embryonic viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural and functional insights into the human Upf1 helicase core

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SF1 and SF2 helicases: family matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structure and mechanism of helicases and nucleic acid translocases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Genetic and biochemical characterization of mutations in the ATPase and helicase regions of the Upf1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification and characterization of mutations in the UPF1 gene that affect nonsense suppression and the formation of the Upf protein complex but not mRNA turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Upf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Evidence that the Upf1-related molecular motor scans the 3'-UTR to ensure mRNA integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Eukaryote-specific domains in translation initiation factors: implications for translation regulation and evolution of the translation system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

CWC22 connects pre-mRNA splicing and exon junction complex assembly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A highly conserved region essential for NMD in the Upf2 N-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A UPF3-mediated regulatory switch that maintains RNA surveillance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Meiotic sex chromosome inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay in Drosophila: at the intersection of the yeast and mammalian pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Splicing-dependent NMD does not require the EJC in Schizosaccharomyces pombe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG-1 is a phosphatidylinositol kinase-related protein kinase required for nonsense-mediated mRNA Decay in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Characterization of SMG-9, an essential component of the nonsense-mediated mRNA decay SMG1C complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification and functional analysis of novel phosphorylation sites in the RNA surveillance protein Upf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Role for Upf2p phosphorylation in Saccharomyces cerevisiae nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

An unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural basis of 14-3-3 protein functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structural basis of the PNRC2-mediated link between mrna surveillance and decapping

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG5-PNRC2 is functionally dominant compared with SMG5-SMG7 in mammalian nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

PIN domains in nonsense-mediated mRNA decay and RNAi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mechanisms of endonuclease-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated messenger RNA decay is initiated by endonucleolytic cleavage in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A post-translational regulatory switch on UPF1 controls targeted mRNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay (NMD) in animal embryogenesis: to die or not to die, that is the question

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

NMD is essential for hematopoietic stem and progenitor cells and for eliminating by-products of programmed DNA rearrangements

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Smg1 is required for embryogenesis and regulates diverse genes via alternative splicing coupled to nonsense-mediated mRNA decay

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

UPF2 is a critical regulator of liver development, function and regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The multiple lives of NMD factors: balancing roles in gene and genome regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated mRNA decay in human cells: mechanistic insights, functions beyond quality control and the double-life of NMD factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mutations of the UPF3B gene, which encodes a protein widely expressed in neurons, are associated with nonspecific mental retardation with or without autism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A novel frameshift mutation in UPF3B identified in brothers affected with childhood onset schizophrenia and autism spectrum disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Broadening the phenotype associated with mutations in UPF3B: two further cases with renal dysplasia and variable developmental delay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Exome sequencing identifies UPF3B as the causative gene for a Chinese non-syndrome mental retardation pedigree.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Transcriptome profiling of UPF3B/NMD-deficient lymphoblastoid cells from patients with various forms of intellectual disability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

An alternative branch of the nonsense-mediated decay pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Spatial and temporal mapping of de novo mutations in schizophrenia to a fetal prefrontal cortical network

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Thrombocytopenia-absent radius syndrome: a clinical genetic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Short stature, Robin sequence, cleft mandible, pre/postaxial hand anomalies, and clubfoot: a new autosomal recessive syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A noncoding expansion in EIF4A3 causes Richieri-Costa-Pereira syndrome, a craniofacial disorder associated with limb defects

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

RNA surveillance. Unforeseen consequences for gene expression, inherited genetic disorders and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Ataluren as an agent for therapeutic nonsense suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A meta-analysis of nonsense mutations causing human genetic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

NMD: RNA biology meets human genetic medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Nonsense-mediated decay approaches the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Long mutant dystrophins and variable phenotypes: evasion of nonsense-mediated decay?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Pharmacologic therapy for stop mutations: how much CFTR activity is enough?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Aminoglycoside antibiotics: old drugs and new therapeutic approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Suppression of a CFTR premature stop mutation in a bronchial epithelial cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

PTC124 targets genetic disorders caused by nonsense mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Mechanism of PTC124 activity in cell-based luciferase assays of nonsense codon suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

A lack of premature termination codon read-through efficacy of PTC124 (Ataluren) in a diverse array of reporter assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

beta 0 thalassemia, a nonsense mutation in man

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

The nonsense-mediated decay pathway and mutually exclusive expression of alternatively spliced FGFR2IIIb and -IIIc mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00018-015-2017-9

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon

21 January 2018

1 reference

12 December 2020

Identification of a selenocysteyl-tRNA(Ser) in mammalian cells that recognizes the nonsense codon, UGA.

1 reference

12 December 2020

Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3.

1 reference

12 December 2020

Translation is required to remove Y14 from mRNAs in the cytoplasm

1 reference

12 December 2020

mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence

1 reference

12 December 2020

A new kind of informational suppression in the nematode Caenorhabditis elegans

1 reference

12 December 2020

Compound inheritance of a low-frequency regulatory SNP and a rare null mutation in exon-junction complex subunit RBM8A causes TAR syndrome

1 reference

12 December 2020

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G

1 reference

12 December 2020

Frameshift suppression Saccharomyces cerevisiae. II. Genetic properties of group II suppressors.

1 reference

12 December 2020

Nonsense codon mutations in the terminal exon of the beta-globin gene are not associated with a reduction in beta-mRNA accumulation: a mechanism for the phenotype of dominant beta-thalassemia

1 reference

12 December 2020

Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay

1 reference

12 December 2020

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

1 reference

12 December 2020

Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons

1 reference

12 December 2020

A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells

1 reference

12 December 2020

mRNA surveillance by the Caenorhabditis elegans smg genes

1 reference

12 December 2020

smg-7 is required for mRNA surveillance in Caenorhabditis elegans.

1 reference

12 December 2020

Eukaryotic polypeptide chain release factor eRF3 is an eRF1- and ribosome-dependent guanosine triphosphatase

1 reference

12 December 2020

Incomplete nonsense-mediated mRNA decay in Giardia lamblia

1 reference

12 December 2020

10.1007/S00018-015-2017-9

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26283621%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference