(Q38592069)

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Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome?

scientific article published on August 2015

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24 February 2020

Translation of Pre-Clinical Studies into Successful Clinical Trials for Alzheimer's Disease: What are the Roadblocks and How Can They Be Overcome? (English)

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24 February 2020

Alzheimer's disease

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M. V. Padma Srivastava

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Dheeraj Khurana

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Avijit Banik

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Richard E Brown

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James Bamburg

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Debomoy K Lahiri

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Robert P Friedland

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Wei Chen

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Amritpal Mudher

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Ante L Padjen

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Elizabeta Mukaetova-Ladinska

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Sudhir Srivastava

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Raj N Kalaria

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Akshay Anand

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Colin L Masters

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1 January 2015

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24 February 2020

Journal of Alzheimer's Disease

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815-843

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24 February 2020

Epidemiology of Alzheimer disease

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21 January 2018

Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors

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The global prevalence of dementia: a systematic review and metaanalysis

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Central Challenges Facing the National Clinical Research Enterprise

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The meaning of translational research and why it matters

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21 January 2018

Fire in the ashes: can failed Alzheimer's disease drugs succeed with second chances?

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21 January 2018

Bacopa monniera ameliorates amnesic effects of diazepam qualifying behavioral-molecular partitioning

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21 January 2018

Scopolamine induced amnesia is reversed by Bacopa monniera through participation of kinase-CREB pathway

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21 January 2018

Antiamnesic effect of B. monniera on L-NNA induced amnesia involves calmodulin

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21 January 2018

Traditional Chinese medicine: a promising candidate for the treatment of Alzheimer's disease

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21 January 2018

The acute effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy normal subjects.

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Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial.

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21 January 2018

Oxidative insults to neurons and synapse are prevented by aged garlic extract and S-allyl-L-cysteine treatment in the neuronal culture and APP-Tg mouse model

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Can animal models of disease reliably inform human studies?

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The animal models of dementia and Alzheimer's disease for pre-clinical testing and clinical translation

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The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.

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The application of cerebrospinal fluid biomarkers in early diagnosis of Alzheimer disease

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A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

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21 January 2018

Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease

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Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence

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First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

Amyloid beta dimers/trimers potently induce cofilin-actin rods that are inhibited by maintaining cofilin-phosphorylation

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Animal models of Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The relevance of individual genetic background and its role in animal models of epilepsy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

What are we measuring when we test strain differences in anxiety in mice?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Strain and sex differences in anxiety-like and social behaviors in C57BL/6J and BALB/cJ mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Sex differences in the brain: the not so inconvenient truth

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Sex difference in pathology and memory decline in rTg4510 mouse model of tauopathy.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Social stress in mice: gender differences and effects of estrous cycle and social dominance.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Sex bias in neuroscience and biomedical research

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Sexual dimorphism in healthy aging and mild cognitive impairment: a DTI study

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Similarities and differences in genome-wide expression data of six organisms

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Dose translation from animal to human studies revisited

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Global similarity and local divergence in human and mouse gene co-expression networks

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Large scale comparison of global gene expression patterns in human and mouse.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A cross-species analysis method to analyze animal models' similarity to human's disease state

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Neuron-Enriched Gene Expression Patterns are Regionally Anti-Correlated with Oligodendrocyte-Enriched Patterns in the Adult Mouse and Human Brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Neuropathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The levels of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Recent rodent models for Alzheimer's disease: clinical implications and basic research

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Plaques, tangles, and memory loss in mouse models of neurodegeneration.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Alzheimer disease models and human neuropathology: similarities and differences

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Interaction between NH(2)-tau fragment and Aβ in Alzheimer's disease mitochondria contributes to the synaptic deterioration

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Epidemiological of and risk factors for Alzheimer's disease: a review

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

What does the pediatrician need to know about Alzheimer disease?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Traumatic brain injury: a risk factor for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Brain aging and late-onset Alzheimer's disease: many open questions

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Lifestyle behavior pattern is associated with different levels of risk for incident dementia and Alzheimer's disease: the Cache County study

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The projected effect of risk factor reduction on Alzheimer's disease prevalence

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Acceleration of brain amyloidosis in an Alzheimer's disease mouse model by a folate, vitamin B6 and B12-deficient diet

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A mouse model characterizing features of vascular dementia with hippocampal atrophy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Pathological synergism between amyloid-beta and apolipoprotein E4--the most prevalent yet understudied genetic risk factor for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The genetics of the human APOE polymorphism

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Are certain lifestyle habits associated with lower Alzheimer's disease risk?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

An active and socially integrated lifestyle in late life might protect against dementia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Life style interventions to reduce the risk of dementia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Prevention in psychiatry: effects of healthy lifestyle on cognition.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and beta-amyloid in the aging brain.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Applying epigenetics to Alzheimer's disease via the latent early-life associated regulation (LEARn) model.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Regulatory innovation and drug development for early-stage Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Clinical and research diagnostic criteria for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Improving animal models for nervous system disorders.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Visual detection, pattern discrimination and visual acuity in 14 strains of mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Age-related changes in visual acuity, learning and memory in C57BL/6J and DBA/2J mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Detecting spatial memory deficits beyond blindness in tg2576 Alzheimer mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Loss of learning in mice when exposed to rat odor: a water maze study.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The lonely mouse: verification of a separation-induced model of depression in female mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The effects of apparatus design and test procedure on learning and memory performance of C57BL/6J mice on the Barnes maze.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Optimization of apparatus design and behavioral measures for the assessment of visuo-spatial learning and memory of mice on the Barnes maze.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A call for transparent reporting to optimize the predictive value of preclinical research

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Publication bias in laboratory animal research: a survey on magnitude, drivers, consequences and potential solutions

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Neuroprotection for ischaemic stroke: translation from the bench to the bedside

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Survey of the quality of experimental design, statistical analysis and reporting of research using animals

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Statistical design considerations in animal studies published recently in cancer research.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Better reporting of randomised controlled trials: the CONSORT statement

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Standards for the publication of mouse mutant studies

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The role of monitoring interpretive rates, concordance between cytotechnologist and pathologist interpretations before sign-out, and turnaround time in gynecologic cytology quality assurance: findings from the College of American Pathologists Gyneco

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Genome-wide association studies in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Genetics of familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Genetics and epigenetics of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Finding the missing heritability of complex diseases

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Targeted proteomics for quantification of histone acetylation in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The benefits of using genetic information to design prevention trials

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

How were new medicines discovered?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Phenotypic vs. target-based drug discovery for first-in-class medicines

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Computational drug repositioning: from data to therapeutics

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Modern phenotypic drug discovery is a viable, neoclassic pharma strategy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Putting the Alzheimer's cognitive test to the test II: Rasch Measurement Theory.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Revising the definition of Alzheimer's disease: a new lexicon.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Promoting interactions with basic scientists and clinicians: the NIA Alzheimer's Disease Data Coordinating Center

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Meeting report: The future of preclinical mouse models in melanoma treatment is now.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Innovative solutions to novel drug development in mental health

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

CNTRICS final animal model task selection: control of attention

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Validation of experimental medicine methods in psychiatry: the P1vital approach and experience

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

The National Alzheimer's Coordinating Center (NACC) database: the Uniform Data Set.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Mary S. Easton Center of Alzheimer's Disease Research at UCLA: advancing the therapeutic imperative

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Alzheimer's disease public-private partnerships: A landscape of the global nonprofit community

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Animal models of neurological disease: are there any babies in the bathwater?

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150136

21 January 2018

Identifiers

10.3233/JAD-150136

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26401762%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26401762%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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