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Drugging Chromatin in Cancer: Recent Advances and Novel Approaches.
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Europe PubMed Central
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4701197
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1 March 2020
title
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches
(English)
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Europe PubMed Central
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4701197
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1 March 2020
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Sheng Cai
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1
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4701197
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1 March 2020
Chun-Wei Chen
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2
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1 March 2020
author name string
Scott A Armstrong
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3
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1 March 2020
publication date
1 November 2015
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1 March 2020
published in
Molecular Cell
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4701197
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1 March 2020
volume
60
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Europe PubMed Central
PMCID
4701197
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26590715%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
page(s)
561-570
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Europe PubMed Central
PMCID
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26590715%20AND%20SRC:MED&resulttype=core&format=json
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1 March 2020
issue
4
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Europe PubMed Central
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1 March 2020
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6 September 2017
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
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6 September 2017
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate
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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
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6 September 2017
MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.
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AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
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6 September 2017
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
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Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells
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6 September 2017
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Epigenetics: a landscape takes shape
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6 September 2017
The fundamental role of epigenetics in hematopoietic malignancies
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6 September 2017
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
hDOT1L links histone methylation to leukemogenesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
The ENCODE (ENCyclopedia Of DNA Elements) Project
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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6 September 2017
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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14 September 2017
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity
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25 September 2017
Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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25 September 2017
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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23 June 2018
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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23 June 2018
Use of clinical next-generation sequencing to identify melanomas harboring SMARCB1 mutations.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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31 August 2018
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies.
1 reference
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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31 August 2018
The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4701197
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31 August 2018
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines
1 reference
stated in
COCI
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27 May 2022
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https://opencitations.net/index/coci/api/v1/citations/10.1158/1535-7163.MCT-11-0182
Identifiers
DOI
10.1016/J.MOLCEL.2015.10.042
1 reference
stated in
Europe PubMed Central
PMCID
4701197
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26590715%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PMCID
4701197
1 reference
stated in
Europe PubMed Central
PMCID
4701197
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26590715%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
PubMed ID
26590715
1 reference
stated in
Europe PubMed Central
PMCID
4701197
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26590715%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 March 2020
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