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English
High-throughput functional genomics using CRISPR-Cas9.
scientific article published on 9 April 2015
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
review article
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stated in
Europe PubMed Central
title
High-throughput functional genomics using CRISPR-Cas9
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
main subject
CRISPR
0 references
genomics
0 references
functional genomics
1 reference
based on heuristic
inferred from title
Cas9
0 references
author
Neville E Sanjana
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
author name string
Ophir Shalem
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
Feng Zhang
series ordinal
3
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stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
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5 March 2020
publication date
9 April 2015
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Europe PubMed Central
PMC publication ID
4503232
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
published in
Nature Reviews Genetics
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stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
volume
16
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stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
issue
5
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Europe PubMed Central
PMC publication ID
4503232
reference URL
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5 March 2020
page(s)
299-311
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Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
describes a project that uses
CRISPR-Cas method
1 reference
based on heuristic
inferred from title
exact match
https://scigraph.springernature.com/pub.10.1038/nrg3899
0 references
cites work
Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds
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GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
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In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
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Whole-genome sequencing analysis reveals high specificity of CRISPR/Cas9 and TALEN-based genome editing in human iPSCs
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12 July 2018
The many faces of RNAi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Harnessing transposons for cancer gene discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Haploid genetic screens in human cells identify host factors used by pathogens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Statistical methods for analysis of high-throughput RNA interference screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Rapid creation and quantitative monitoring of high coverage shRNA libraries
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: RNA interference.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Synthetic lethal screen identification of chemosensitizer loci in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Genome-scale loss-of-function screening with a lentiviral RNAi library
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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12 July 2018
Lessons from Nature: microRNA-based shRNA libraries
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
High-throughput RNAi screening by time-lapse imaging of live human cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Building mammalian signalling pathways with RNAi screens
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
3' UTR seed matches, but not overall identity, are associated with RNAi off-targets
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Second-generation shRNA libraries covering the mouse and human genomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The love-hate relationship between Ras and Notch.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: mouse
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
A computational study of off-target effects of RNA interference
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The ENCODE (ENCyclopedia Of DNA Elements) Project
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Mechanisms of gene silencing by double-stranded RNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
MicroRNAs: small RNAs with a big role in gene regulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
siRNAs: applications in functional genomics and potential as therapeutics
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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12 July 2018
A resource for large-scale RNA-interference-based screens in mammals.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: mammalian culture cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Genome-wide RNAi analysis of growth and viability in Drosophila cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
MicroRNAs: genomics, biogenesis, mechanism, and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: Escherichia coli
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Expression profiling reveals off-target gene regulation by RNAi
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Gene silencing in mammals by small interfering RNAs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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12 July 2018
The art and design of genetic screens: caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: Drosophila melanogaster
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: Arabidopsis thaliana
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: zebrafish
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The art and design of genetic screens: yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Isolation and characterization of a near-haploid human cell line.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Introduction of double-strand breaks into the genome of mouse cells by expression of a rare-cutting endonuclease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Mutations affecting segment number and polarity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Determination of anteroposterior polarity in Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
12 July 2018
Microhomology-based choice of Cas9 nuclease target sites.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
26 September 2018
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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26 September 2018
High-throughput RNAi screening in cultured cells: a user's guide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
retrieved
26 September 2018
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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26 September 2018
A genetic screen for mutations affecting embryogenesis in zebrafish.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4503232
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26 September 2018
Promoter elements regulate cytoplasmic mRNA decay
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Crossref
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https://api.crossref.org/works/10.1038%2FNRG3899
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31 March 2020
Identifiers
DOI
10.1038/NRG3899
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PMC publication ID
4503232
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
PubMed publication ID
25854182
1 reference
stated in
Europe PubMed Central
PMC publication ID
4503232
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25854182%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 March 2020
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