(Q38800643)

6 September 2017

1 reference

title

Viral Vectors: The Road to Reducing Genotoxicity (English)

1 reference

6 September 2017

Rhiannon M David

1

1 reference

PubMed ID

27803388

6 September 2017

Ann T Doherty

series ordinal

2

1 reference

6 September 2017

1 November 2016

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6 September 2017

Toxicological Sciences

1 reference

6 September 2017

155

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6 September 2017

2

1 reference

6 September 2017

315-325

1 reference

Gene therapy for primary immunodeficiencies: Part 2.

6 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The committee for advanced therapies' of the European Medicines Agency reflection paper on management of clinical risks deriving from insertional mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Improved human beta-globin expression from self-inactivating lentiviral vectors carrying the chicken hypersensitive site-4 (cHS4) insulator element

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Ocular gene delivery using lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

General considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Lentiviral vector integration profiles differ in rodent postmitotic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Promoterless gene targeting without nucleases ameliorates haemophilia B in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Lentiviral hematopoietic stem cell gene therapy benefits metachromatic leukodystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Insertional gene activation by lentiviral and gammaretroviral vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

HIV integration site distributions in resting and activated CD4+ T cells infected in culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

High-definition mapping of retroviral integration sites identifies active regulatory elements in human multipotent hematopoietic progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Use of tissue-specific microRNA to control pathology of wild-type adenovirus without attenuation of its ability to kill cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Vector design influences hepatic genotoxicity after adeno-associated virus gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Enhancers are major targets for murine leukemia virus vector integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

AAV vector integration sites in mouse hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

A chromatin insulator protects retrovirus vectors from chromosomal position effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Suppression of clonal dominance in cultured human lymphoid cells by addition of the cHS4 insulator to a lentiviral vector

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Efficacy of gene therapy for X-linked severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

High-throughput insertional mutagenesis screens in mice to identify oncogenic networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Molecular mechanisms of retroviral integration site selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

MLV integration site selection is driven by strong enhancers and active promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Retroviral DNA integration: viral and cellular determinants of target-site selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Transcriptome comparison between fetal and adult mouse livers: implications for circadian clock mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Genomic and functional assays demonstrate reduced gammaretroviral vector genotoxicity associated with use of the cHS4 chromatin insulator

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Insertional mutagenesis by replication-deficient retroviral vectors encoding the large T oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Genomic discovery of potent chromatin insulators for human gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Direct comparison of the insulating properties of two genetic elements in an adenoviral vector containing two different expression cassettes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Patient monitoring and follow-up in lentiviral clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Hematopoietic stem cell gene transfer in a tumor-prone mouse model uncovers low genotoxicity of lentiviral vector integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Integration site and clonal expansion in human chronic retroviral infection and gene therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Incorporating double copies of a chromatin insulator into lentiviral vectors results in less viral integrants

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Stable gammaretroviral vector expression during embryonic stem cell-derived in vitro hematopoietic development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Study of long-distance functional interactions between Su(Hw) insulators that can regulate enhancer-promoter communication in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

CRISPR genome engineering and viral gene delivery: a case of mutual attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

HIV-1 integration in the human genome favors active genes and local hotspots

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Gene therapy matures in the clinic

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Lentiviral Nef suppresses iron uptake in a strain specific manner through inhibition of Transferrin endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Insulation from viral transcriptional regulatory elements improves inducible transgene expression from adenovirus vectors in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Alpharetroviral vectors: from a cancer-causing agent to a useful tool for human gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Retroviral insertion mutagenesis in mice as a comparative oncogenomics tool to identify disease genes in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Genotoxicity of retroviral hematopoietic stem cell gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The chicken hypersensitivity site 4 core insulator blocks promoter interference in lentiviral vectors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

The CD20/alphaCD20 'suicide' system: novel vectors with improved safety and expression profiles and efficient elimination of CD20-transgenic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Long-term correction of Sandhoff disease following intravenous delivery of rAAV9 to mouse neonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Analysis of lentiviral vector integration in HIV+ study subjects receiving autologous infusions of gene modified CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Transcription start regions in the human genome are favored targets for MLV integration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Overlapping enhancer/promoter and transcriptional termination signals in the lentiviral long terminal repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Current advances in retroviral gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

RNA 3' readthrough of oncoretrovirus and lentivirus: implications for vector safety and efficacy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFW220

21 January 2018

Identifiers

DOI

10.1093/TOXSCI/KFW220

1 reference

6 September 2017

1 reference

PubMed ID

27803388