(Q38828825)

6 September 2017

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title

The biology and function of fibroblasts in cancer (English)

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6 September 2017

Raghu Kalluri

1

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PubMed ID

27550820

6 September 2017

language of work or name

English

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publication date

1 August 2016

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6 September 2017

Nature Reviews Cancer

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6 September 2017

16

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6 September 2017

9

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6 September 2017

582-598

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https://scigraph.springernature.com/pub.10.1038/nrc.2016.73

6 September 2017

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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis.

31 March 2020

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Identification and characterization of a fibroblast marker: FSP1

31 March 2020

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Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

31 March 2020

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Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: an important autocrine/paracrine factor in tumor progression

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Tumoral immune suppression by macrophages expressing fibroblast activation protein-α and heme oxygenase-1.

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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

31 March 2020

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Identification of fibroblast heterogeneity in the tumor microenvironment

31 March 2020

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Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production.

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Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

31 March 2020

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Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis

31 March 2020

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Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment.

31 March 2020

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Colorectal Cancer-Associated Fibroblasts are Genotypically Distinct

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Distinct epigenetic changes in the stromal cells of breast cancers

31 March 2020

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Methylation determines fibroblast activation and fibrogenesis in the kidney

31 March 2020

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Histone modifications are responsible for decreased Fas expression and apoptosis resistance in fibrotic lung fibroblasts.

31 March 2020

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Epigenetic regulation of Thy-1 gene expression by histone modification is involved in lipopolysaccharide-induced lung fibroblast proliferation

31 March 2020

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Hypoxia-induced DNA hypermethylation in human pulmonary fibroblasts is associated with Thy-1 promoter methylation and the development of a pro-fibrotic phenotype

31 March 2020

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Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling

31 March 2020

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Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts

31 March 2020

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Modulated expression of WFDC1 during carcinogenesis and cellular senescence

31 March 2020

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

31 March 2020

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In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts

31 March 2020

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The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

31 March 2020

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Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells.

31 March 2020

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Tumor cell interactions with the extracellular matrix during invasion and metastasis

31 March 2020

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The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

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Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells

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TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis.

31 March 2020

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Exosomes in tumor microenvironment influence cancer progression and metastasis

31 March 2020

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Tumor-stroma interaction: Revealing fibroblast-secreted exosomes as potent regulators of Wnt-planar cell polarity signaling in cancer metastasis

31 March 2020

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Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

31 March 2020

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Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

31 March 2020

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Interactions between cancer stem cells and their niche govern metastatic colonization

31 March 2020

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

31 March 2020

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Mesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization

31 March 2020

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Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling.

31 March 2020

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Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice

31 March 2020

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Local and systemic protumorigenic effects of cancer-associated fibroblast-derived GDF15.

31 March 2020

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

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Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

31 March 2020

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VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization

31 March 2020

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Tumor-dependent activation of rodent hepatic stellate cells during experimental melanoma metastasis

31 March 2020

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Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

31 March 2020

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STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer

31 March 2020

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

31 March 2020

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Suppression of tumor development and metastasis formation in mice lacking the S100A4(mts1) gene

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

31 March 2020

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Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.

31 March 2020

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Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor

31 March 2020

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The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

31 March 2020

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PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

31 March 2020

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes inflammation and tumorigenesis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

31 March 2020

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Hypoxia and loss of PHD2 inactivate stromal fibroblasts to decrease tumour stiffness and metastasis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

31 March 2020

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Metabolism of stromal and immune cells in health and disease

31 March 2020

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T Cells and Cancer: How Metabolism Shapes Immunity

31 March 2020

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Immunological hallmarks of stromal cells in the tumour microenvironment

31 March 2020

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Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery

31 March 2020

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Identification of two distinct carcinoma-associated fibroblast subtypes with differential tumor-promoting abilities in oral squamous cell carcinoma

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRC.2016.73

Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations

31 March 2020

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Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A.

31 March 2020

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Classification and biology of tumour associated stromal cells

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Regulation of the anti-tumour immune response by cancer-associated fibroblasts

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Mechanisms of tumor escape from immune system: role of mesenchymal stromal cells.

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IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation.

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IL-6 switches the differentiation of monocytes from dendritic cells to macrophages

31 March 2020

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Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment

31 March 2020

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'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation

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Th17 cells in cancer: the ultimate identity crisis.

31 March 2020

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The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Crosstalk between fibroblasts and inflammatory cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Tumor-associated fibroblasts recruit blood monocytes into tumor tissue.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Cancer-associated fibroblasts as another polarized cell type of the tumor microenvironment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

New functions for the matrix metalloproteinases in cancer progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Cancer-associated fibroblast-targeted strategy enhances antitumor immune responses in dendritic cell-based vaccine

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Modulation of tumor cell response to chemotherapy by the organ environment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Environment-mediated drug resistance: a major contributor to minimal residual disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Fibroblast-mediated drug resistance in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

High interstitial fluid pressure - an obstacle in cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

The tumor microenvironment is a dominant force in multidrug resistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

The impact of tumor stroma on drug response in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Addressing the role of cell adhesion in tumor cell dormancy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Fibroblasts contribute to melanoma tumor growth and drug resistance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

EMT, CTCs and CSCs in tumor relapse and drug-resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Role of interleukin-6 in cancer progression and therapeutic resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Vascular normalization as an emerging strategy to enhance cancer immunotherapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Reconstruction of functionally normal and malignant human breast tissues in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Reversing the aging stromal phenotype prevents carcinoma initiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Prognostic relevance of cancer-associated fibroblasts in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Intratumoral α-SMA enhances the prognostic potency of CD34 associated with maintenance of microvessel integrity in hepatocellular carcinoma and pancreatic cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Stromal gene expression predicts clinical outcome in breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Prognostic significance in breast cancer of a gene signature capturing stromal PDGF signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

The M1 and M2 paradigm of macrophage activation: time for reassessment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Localized Smooth Muscle Differentiation Is Essential for Epithelial Bifurcation during Branching Morphogenesis of the Mammalian Lung

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Bending gradients: how the intestinal stem cell gets its home

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

The basics of epithelial-mesenchymal transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Diversity, topographic differentiation, and positional memory in human fibroblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Mesenchymal stromal cells and fibroblasts: a case of mistaken identity?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

LIF mediates proinvasive activation of stromal fibroblasts in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

System-wide analysis reveals a complex network of tumor-fibroblast interactions involved in tumorigenicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC.2016.73

Idiopathic pulmonary fibrosis will increase the risk of lung cancer

31 March 2020

1 reference

12 December 2020

Myofibroblasts. I. Paracrine cells important in health and disease

1 reference

12 December 2020

Epithelial-mesenchymal transition and drug resistance: role, molecular mechanisms, and therapeutic strategies

1 reference

12 December 2020

Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium

1 reference

12 December 2020

Ultrastructural features of wound healing in mouse skin

1 reference

12 December 2020

Role of periostin in cancer progression and metastasis: inhibition of breast cancer progression and metastasis by anti-periostin antibody in a murine model

1 reference

12 December 2020

Contribution of genetics and epigenetics to progression of kidney fibrosis

1 reference

12 December 2020

Fibroblasts and myofibroblasts in wound healing

1 reference

12 December 2020

Stroma: fertile soil for inflammation

1 reference

12 December 2020

Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast

1 reference

12 December 2020

N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells

1 reference

12 December 2020

Transforming growth factor-beta1 induces desmoplasia in an experimental model of human pancreatic carcinoma

1 reference

12 December 2020

Activation of lung connective tissue cells in vitro

1 reference

12 December 2020

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia

1 reference

12 December 2020

Role of fibroblast activation in inducing interstitial fibrosis

1 reference

12 December 2020

Foetal and cancer patient fibroblasts produce an autocrine migration-stimulating factor not made by normal adult cells

1 reference

12 December 2020

Contribution of bone marrow-derived fibrocytes to liver fibrosis

1 reference

12 December 2020

Does idiopathic pulmonary fibrosis increase lung cancer risk?

1 reference

12 December 2020

HHF35, a muscle actin-specific monoclonal antibody. II. Reactivity in normal, reactive, and neoplastic human tissues.

1 reference

12 December 2020

Myofibroblasts in an avascular fibrous tissue

1 reference

12 December 2020

The interplay of matrix metalloproteinases, morphogens and growth factors is necessary for branching of mammary epithelial cells.

1 reference

12 December 2020

Pathogenesis of desmoplasia. I. Immunofluorescence identification and localization of some structural proteins of line 1 and line 10 guinea pig tumors and of healing wounds.

1 reference

12 December 2020

The myofibroblast, multiple origins for major roles in normal and pathological tissue repair.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRC.2016.73

1 reference

PubMed ID

27550820

Dimensions Publication ID

6 September 2017

0 references

1 reference

PubMed ID

27550820