(Q38888042)

7 September 2017

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title

Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets (English)

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7 September 2017

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Stephen Safe

1

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7 September 2017

Ravi Kasiappan

series ordinal

2

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7 September 2017

publication date

7 July 2016

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7 September 2017

published in

Phytotherapy Research

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7 September 2017

volume

30

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7 September 2017

issue

11

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7 September 2017

page(s)

1723-1732

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Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells

7 September 2017

cites work

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Molecular targets of dietary agents for prevention and therapy of cancer

21 January 2018

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Pharmacological properties of the ubiquitous natural product betulin

21 January 2018

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RAR and RXR modulation in cancer and metabolic disease

21 January 2018

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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl

21 January 2018

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Predictive value of Sp1/Sp3/FLIP signature for prostate cancer recurrence

21 January 2018

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Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

21 January 2018

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The Beginnings of Drug Therapy: Ancient Mesopotamian Medicine

21 January 2018

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The role of natural product chemistry in drug discovery

21 January 2018

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Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells

21 January 2018

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Curcumin decreases specificity protein expression in bladder cancer cells

21 January 2018

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Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells

21 January 2018

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Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors

21 January 2018

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Anti-proliferative properties of kahweol in oral squamous cancer through the regulation specificity protein 1.

21 January 2018

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Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis

21 January 2018

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Differential in vivo mechanism of chemoprevention of tumor formation in azoxymethane/dextran sodium sulfate mice by PEITC and DBM.

21 January 2018

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Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation

21 January 2018

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Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells

21 January 2018

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Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins

21 January 2018

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Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors

21 January 2018

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Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors

21 January 2018

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Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells

21 January 2018

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Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice

21 January 2018

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Metabolism of plant-derived anticancer agents

21 January 2018

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Impact of natural products on developing new anti-cancer agents

21 January 2018

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Plants as a source of anti-cancer agents

21 January 2018

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Natural products in drug discovery and development

21 January 2018

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Ancient-modern concordance in Ayurvedic plants: some examples

21 January 2018

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Phase II trial of curcumin in patients with advanced pancreatic cancer

21 January 2018

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Pro-apoptotic activities of polyphenolics from açai (Euterpe oleracea Martius) in human SW-480 colon cancer cells.

21 January 2018

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The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

21 January 2018

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Betulinic acid-induced apoptosis in leukemia cells

21 January 2018

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Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness

21 January 2018

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The value of plants used in traditional medicine for drug discovery

21 January 2018

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The Chinese herb isolate isorhapontigenin induces apoptosis in human cancer cells by down-regulating overexpression of antiapoptotic protein XIAP.

21 January 2018

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Significant biological role of sp1 transactivation in multiple myeloma

21 January 2018

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Betulinic Acid for cancer treatment and prevention

21 January 2018

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Betulinic acid induces apoptosis through a direct effect on mitochondria in neuroectodermal tumors.

21 January 2018

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Targeting mitochondrial apoptosis by betulinic acid in human cancers

21 January 2018

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Activation of Mitochondria and Release of Mitochondrial Apoptogenic Factors by Betulinic Acid

21 January 2018

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Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes

21 January 2018

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Mitochondria as therapeutic targets for cancer chemotherapy

21 January 2018

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Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs

21 January 2018

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Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death

21 January 2018

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Alterations in the Sp1 binding and Fmr-1 gene expression in the cortex of the brain during maturation and aging of mouse

21 January 2018

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Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs

21 January 2018

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Sp1 is upregulated in human glioma, promotes MMP-2-mediated cell invasion and predicts poor clinical outcome

21 January 2018

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miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1.

21 January 2018

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Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

21 January 2018

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Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

21 January 2018

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Retinoids in chemoprevention and differentiation therapy

21 January 2018

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Antiangiogenic activity of Tripterygium wilfordii and its terpenoids

21 January 2018

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Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

21 January 2018

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Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors

21 January 2018

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Potential synergism of natural products in the treatment of cancer

21 January 2018

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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

21 January 2018

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Sp1 expression regulates lung tumor progression.

21 January 2018

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alpha-Tocopheryl succinate and derivatives mediate the transcriptional repression of androgen receptor in prostate cancer cells by targeting the PP2A-JNK-Sp1-signaling axis

21 January 2018

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Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression

21 January 2018

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Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells

21 January 2018

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Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation

21 January 2018

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Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth

21 January 2018

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Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents

21 January 2018

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Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cance

21 January 2018

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Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer.

21 January 2018

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Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy

21 January 2018

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Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status

21 January 2018

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Lycopene suppresses the lipopolysaccharide-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and nuclear factor-kappaB.

21 January 2018

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Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters

21 January 2018

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Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin

21 January 2018

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The evolving role of natural products in drug discovery

21 January 2018

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Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.

21 January 2018

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Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer

21 January 2018

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A regulatory loop involving miR-22, Sp1, and c-Myc modulates CD147 expression in breast cancer invasion and metastasis

21 January 2018

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Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules

21 January 2018

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Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence.

21 January 2018

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Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.

21 January 2018

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Regulation of adipogenesis by natural and synthetic REV-ERB ligands.

21 January 2018

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Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

21 January 2018

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Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma

21 January 2018

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JMJD2A-dependent silencing of Sp1 in advanced breast cancer promotes metastasis by downregulation of DIRAS3.

21 January 2018

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Targeting cancer stem cells by curcumin and clinical applications

21 January 2018

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DNA topoisomerase poisons as antitumor drugs

21 January 2018

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Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer

21 January 2018

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Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.

21 January 2018

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Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation

21 January 2018

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The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells.

21 January 2018

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Diverse actions of retinoid receptors in cancer prevention and treatment.

21 January 2018

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Betulinic acid and its derivatives as anti-angiogenic agents.

21 January 2018

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Cruciferous vegetables and cancer prevention

21 January 2018

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Apoptosis Induction in HL-60 Cells and Inhibition of Topoisomerase II by Triterpene Celastrol

21 January 2018

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Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors

21 January 2018

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ZEB2-Sp1 cooperation induces invasion by upregulating cadherin-11 and integrin α5 expression.

21 January 2018

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The influence of natural products upon drug discovery

21 January 2018

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Natural products as sources of new drugs over the period 1981-2002.

21 January 2018

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The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis.

21 January 2018

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Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

21 January 2018

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Downregulation of transcription factor, Sp1, during cellular senescence

21 January 2018

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Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway

21 January 2018

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Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met.

21 January 2018

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New perspectives of curcumin in cancer prevention.

21 January 2018

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Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors

21 January 2018

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Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors.

21 January 2018

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Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells

21 January 2018

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Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation

21 January 2018

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Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis

21 January 2018

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Differential response of normal (PrEC) and cancerous human prostate cells (PC-3) to phenethyl isothiocyanate-mediated changes in expression of antioxidant defense genes

21 January 2018

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Acute effects of 4-ipomeanol on experimental lung tumors with bronchiolar or alveolar cell features in Syrian hamsters or C3H/HeNCr mice.

21 January 2018

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Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target

21 January 2018

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Minireview: role of orphan nuclear receptors in cancer and potential as drug targets

21 January 2018

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Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs

21 January 2018

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The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate

21 January 2018

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Celastrol: Molecular targets of Thunder God Vine

21 January 2018

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The multifaceted role of curcumin in cancer prevention and treatment.

21 January 2018

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Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance

21 January 2018

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Orphan nuclear receptors in drug discovery

21 January 2018

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Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis

21 January 2018

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Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression

21 January 2018

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Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9.

21 January 2018

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Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research

21 January 2018

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Nuclear receptors: decoding metabolic disease

21 January 2018

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Retinoic acid receptors and cancers.

21 January 2018

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Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors

21 January 2018

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Mammalian SP/KLF transcription factors: bring in the family

21 January 2018

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Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

21 January 2018

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Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.

21 January 2018

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Indole-3-carbinol suppresses NF-kappaB and IkappaBalpha kinase activation, causing inhibition of expression of NF-kappaB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

21 January 2018

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Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion

21 January 2018

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Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion

21 January 2018

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From carrot to clinic: an overview of the retinoic acid signaling pathway

21 January 2018

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate.

21 January 2018

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Sp1 transcription factor: A long-standing target in cancer chemotherapy

21 January 2018

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SP1 mediates the link between methylation of the tumour suppressor miR-149 and outcome in colorectal cancer

21 January 2018

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Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

21 January 2018

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Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

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Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity

21 January 2018

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Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase-3, mitochondria dysfunction and nitric oxide (NO) in human oste

21 January 2018

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Phenethyl isothiocyanate-induced apoptosis in PC-3 human prostate cancer cells is mediated by reactive oxygen species-dependent disruption of the mitochondrial membrane potential

21 January 2018

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Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells

21 January 2018

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Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.

21 January 2018

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Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

21 January 2018

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Association between expression of transcription factor Sp1 and increased vascular endothelial growth factor expression, advanced stage, and poor survival in patients with resected gastric cancer

21 January 2018

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Betulinic acid and its derivatives: a review on their biological properties

21 January 2018

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Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax.

21 January 2018

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Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way.

21 January 2018

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Transcription factor Sp1 expression in gastric cancer and its relationship to long-term prognosis

21 January 2018

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Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14

21 January 2018

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MTA2 promotes gastric cancer cells invasion and is transcriptionally regulated by Sp1

21 January 2018

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Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol

21 January 2018

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Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway

21 January 2018

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Up-regulation of death receptor 4 and 5 by celastrol enhances the anti-cancer activity of TRAIL/Apo-2L.

21 January 2018

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Inhibition of NF-κB activation through targeting IκB kinase by celastrol, a quinone methide triterpenoid

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/PTR.5669

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7 September 2017

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