(Q39190194)

9 September 2017

title

Strategies to Target Glucose Metabolism in Tumor Microenvironment on Cancer by Flavonoids (English)

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9 September 2017

Gang Wang

1

1 reference

9 September 2017

Jun-Jie Wang

2

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9 September 2017

Rui Guan

3

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9 September 2017

Li Du

4

1 reference

9 September 2017

Jing Gao

5

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9 September 2017

Xing-Li Fu

6

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9 September 2017

publication date

21 March 2017

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9 September 2017

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9 September 2017

volume

69

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9 September 2017

issue

4

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9 September 2017

page(s)

534-554

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Cancer cell metabolism: one hallmark, many faces.

9 September 2017

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Glycolysis inhibition for anticancer treatment

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The cancer cell's "power plants" as promising therapeutic targets: an overview

21 January 2018

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Chronic quercetin exposure affects fatty acid catabolism in rat lung

21 January 2018

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Transcriptome and proteome profiling of colon mucosa from quercetin fed F344 rats point to tumor preventive mechanisms, increased mitochondrial fatty acid degradation and decreased glycolysis

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Energy boost: the Warburg effect returns in a new theory of cancer

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

21 January 2018

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Cancer cell metabolism: Warburg and beyond

21 January 2018

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Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

21 January 2018

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Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

21 January 2018

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CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation

21 January 2018

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Hallmarks of Cancer: The Next Generation

21 January 2018

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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2

21 January 2018

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Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer

21 January 2018

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Multifaceted roles of glycolytic enzymes.

21 January 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

21 January 2018

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Inactivation of the HIF-1α/PDK3 signaling axis drives melanoma toward mitochondrial oxidative metabolism and potentiates the therapeutic activity of pro-oxidants

21 January 2018

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Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

21 January 2018

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Metabolic modulation of glioblastoma with dichloroacetate

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Hypoxia-inducible factors in physiology and medicine

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Insulin-stimulated glucose uptake occurs in specialized cells within the cumulus oocyte complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibition of cell proliferation and glucose uptake in human laryngeal carcinoma cells by antisense oligonucleotides against glucose transporter-1.

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The expression and significance of HIF-1alpha and GLUT-3 in glioma.

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Chemopreventive efficacy of hesperetin (citrus flavonone) against 1,2-dimethylhydrazine-induced rat colon carcinogenesis.

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Bioactive compounds from Mexican lime ( Citrus aurantifolia ) juice induce apoptosis in human pancreatic cells.

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Role of hesperetin (a natural flavonoid) and its analogue on apoptosis in HT-29 human colon adenocarcinoma cell line--a comparative study

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Interaction of hesperetin glucuronide conjugates with human BCRP, MRP2 and MRP3 as detected in membrane vesicles of overexpressing baculovirus-infected Sf9 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Overcoming trastuzumab resistance in breast cancer by targeting dysregulated glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

21 January 2018

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https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Decreased pyruvate kinase M2 activity linked to cisplatin resistance in human gastric carcinoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

A proteomic approach links decreased pyruvate kinase M2 expression to oxaliplatin resistance in patients with colorectal cancer and in human cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Pyruvate Kinase M2 Modulates Esophageal Squamous Cell Carcinoma Chemotherapy Response by Regulating the Pentose Phosphate Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Efficacy of RNAi targeting of pyruvate kinase M2 combined with cisplatin in a lung cancer model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Silencing of pkm2 increases the efficacy of docetaxel in human lung cancer xenografts in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The role of mTOR during cisplatin treatment in an in vitro and ex vivo model of cervical cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Expression of an activated mammalian target of rapamycin in adenocarcinoma of the cervix: A potential biomarker and molecular target therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The pharmacological point of view of resistance to therapy in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Targeting cisplatin-resistant human tumor cells with metabolic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Glycation of glutamate cysteine ligase by 2-deoxy-d-ribose and its potential impact on chemoresistance in glioblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Regulation of glucose transport by hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Combining bevacizumab with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Why do cancers have high aerobic glycolysis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Gene expression of GLUT3 and GLUT1 glucose transporters in human brain tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Oroxylin A sensitizes non-small cell lung cancer cells to anoikis via glucose-deprivation-like mechanisms: c-Src and hexokinase II.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Oroxylin A induces dissociation of hexokinase II from the mitochondria and inhibits glycolysis by SIRT3-mediated deacetylation of cyclophilin D in breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF-1α and glycolysis, by inhibiting PI3K/Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibition of lactate transport and glycolysis in Ehrlich ascites tumor cells by bioflavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Quercetin, an artificial regulator of the high aerobic glycolysis of tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

SIRT1 stimulation by polyphenols is affected by their stability and metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Luteolin as a glycolysis inhibitor offers superior efficacy and lesser toxicity of doxorubicin in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

LKB1; linking cell structure and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Dyslipidaemia and dysglycaemia in HIV-infected patients on highly active anti-retroviral therapy in Kumasi Metropolis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Quercetin and epigallocatechin gallate inhibit glucose uptake and metabolism by breast cancer cells by an estrogen receptor-independent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Hexose transporter GLUT1 harbors several distinct regulatory binding sites for flavones and tyrphostins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibition of the intestinal glucose transporter GLUT2 by flavonoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Estrogen receptor β ligands: recent advances and biomedical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Naringenin inhibits glucose uptake in MCF-7 breast cancer cells: a mechanism for impaired cellular proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Mechanisms of naringenin-induced apoptotic cascade in cancer cells: involvement of estrogen receptor alpha and beta signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Expression of hexokinase II and Glut-1 in untreated human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Mechanisms underlying the protective effects of myricetin and quercetin following oxygen-glucose deprivation-induced cell swelling and the reduction in glutamate uptake in glial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Characterization and modulation of glucose uptake in a human blood-brain barrier model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Regulation of GLUT transporters by flavonoids in androgen-sensitive and -insensitive prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Anticancer mechanism of apigenin and the implications of GLUT-1 expression in head and neck cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Energy metabolism in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Targeting cellular metabolism to improve cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Mutant p53 and mTOR/PKM2 regulation in cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Flavonoids: A versatile source of anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Flavonoids as prospective compounds for anti-cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibitory and Activating Effects of Some Flavonoid Derivatives on Human Pyruvate Kinase Isoenzyme M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Potential anticancer activity of myricetin in human T24 bladder cancer cells both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

In vitro effects of some flavonoids and phenolic acids on human pyruvate kinase isoenzyme M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Changes in pH and blood flow induced by glucose, and their effects on hyperthermia with or without BCNU in RIF-1 tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Re-setting the biologic rationale for thermal therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The cellular and molecular basis of hyperthermia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Synergistic down-regulation of signal transduction and cytotoxicity by tiazofurin and quercetin in human ovarian carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Peroral application of water-soluble derivative of propolis (WSDP) and its related polyphenolic compounds and their influence on immunological and antitumour activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Protective effects of propolis and related polyphenolic/flavonoid compounds against toxicity induced by irinotecan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Protective effect of grape seed proanthocyanidin extract against oxidative stress induced by cisplatin in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The transport barrier in intraperitoneal therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Targeting HSP70-induced thermotolerance for design of thermal sensitizers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Radioprotective effects of propolis and quercetin in gamma-irradiated mice evaluated by the alkaline comet assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Quercetin and hyperthermia modulate cisplatin-induced DNA damage in tumor and normal tissues in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Flavopiridol: An Old Drug With New Perspectives? Implication for Development of New Drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

The role of Myc and let-7a in glioblastoma, glucose metabolism and response to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

FV-429 induces apoptosis and inhibits glycolysis by inhibiting Akt-mediated phosphorylation of hexokinase II in MDA-MB-231 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Flavonoids as drugs at the small intestinal level

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Flavonoid glycosides are not transported by the human Na+/glucose transporter when expressed in Xenopus laevis oocytes, but effectively inhibit electrogenic glucose uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Sugar absorption in the intestine: the role of GLUT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

Inhibition of intestinal and renal Na+-glucose cotransporter by naringenin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F01635581.2017.1295090

10.1080/01635581.2017.1295090

21 January 2018

Identifiers

DOI

1 reference

9 September 2017

1 reference