(Q39241369)

10 September 2017

Attractor landscape analysis reveals feedback loops in the p53 network that control the cellular response to DNA damage (English)

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10 September 2017

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5

Kwang-Hyun Cho

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10 September 2017

Minsoo Choi

1

1 reference

10 September 2017

Jue Shi

series ordinal

2

1 reference

10 September 2017

Sung Hoon Jung

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3

1 reference

10 September 2017

Xi Chen

series ordinal

4

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10 September 2017

20 November 2012

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10 September 2017

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10 September 2017

5

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10 September 2017

251

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10 September 2017

ra83

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Initiating cellular stress responses

10 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Tumor suppressive functions of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Dynamics of the p53-Mdm2 feedback loop in individual cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Oscillations and variability in the p53 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The first 30 years of p53: growing ever more complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The P53 pathway: what questions remain to be explored?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Boolean network-based analysis of the apoptosis network: irreversible apoptosis and stable surviving.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Oscillations and bistability in the stochastic model of p53 regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Explaining oscillations and variability in the p53-Mdm2 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The cellular response to p53: the decision between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The p53 pathway: positive and negative feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

A deterministic map of Waddington's epigenetic landscape for cell fate specification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Recipes and mechanisms of cellular reprogramming: a case study on budding yeast Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Conrad Hal Waddington: the last Renaissance biologist?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Regulation of the cyclin E gene by transcription factor E2F1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Mechanisms of caspase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Quantifying robustness and dissipation cost of yeast cell cycle network: the funneled energy landscape perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Analysis of feedback loops and robustness in network evolution based on Boolean models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Coherent coupling of feedback loops: a design principle of cell signaling networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Boolean dynamics of biological networks with multiple coupled feedback loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Cell fate decision mediated by p53 pulses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

p53 dynamics control cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

p53 modulation of the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Altered regulation of cyclin G in human breast cancer and its specific localization at replication foci in response to DNA damage in p53+/+ cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Apoptosis in the absence of caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Targeting the MDM2-p53 interaction for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Structural and functional basis for therapeutic modulation of p53 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Drug discovery and assay development in the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Strategies for manipulating the p53 pathway in the treatment of human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Antitumor activity of the selective MDM2 antagonist nutlin-3 against chemoresistant neuroblastoma with wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

PPM1D silencing by RNA interference inhibits proliferation and induces apoptosis in breast cancer cell lines with wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The strength of indecisiveness: oscillatory behavior for better cell fate determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Regulation of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Probabilistic Boolean Networks: a rule-based uncertainty model for gene regulatory networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Cell-cycle checkpoints and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Regulation of CDK/cyclin complexes during the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The retinoblastoma protein and cell cycle control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The Rb/E2F pathway and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Cyclin-dependent kinases and pRb: regulators of the proliferation-differentiation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The many substrates and functions of ATM

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Complicating the complexity of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Bax-induced apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

BCL-2 family: regulators of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Control of apoptosis by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

A mathematical model of caspase function in apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Neural networks and physical systems with emergent collective computational abilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Robustness and evolvability in genetic regulatory networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The negative role of cyclin G in ATM-dependent p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

ATM is a target for positive regulation by E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Post-translational modifications and activation of p53 by genotoxic stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Mechanism of p53 stabilization by ATM after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Tumor suppression by Ink4a-Arf: progress and puzzles

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

MDM2 promotes ubiquitination and degradation of MDMX

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Regulation of PTEN transcription by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Lost in transcription: p21 repression, mechanisms, and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

E2F - at the crossroads of life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Degradation of retinoblastoma protein in tumor necrosis factor- and CD95-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

mdm2: a bridge over the two tumour suppressors, p53 and Rb.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

DNA-damage-responsive acetylation of pRb regulates binding to E2F-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Inhibition of Bax channel-forming activity by Bcl-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Bax-induced caspase activation and apoptosis via cytochrome c release from mitochondria is inhibitable by Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

E2F1 pathways to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2003363

10.1126/SCISIGNAL.2003363

21 January 2018

Identifiers

DOI

1 reference

10 September 2017

1 reference