(Q39809467)

14 September 2017

Effects of stability on the biological function of p53. (English)

1 reference

14 September 2017

3

Alan R Fersht

1 reference

14 September 2017

Kian Hoe Khoo

1

1 reference

PMCID

2781498

14 September 2017

Sebastian Mayer

series ordinal

2

1 reference

PMCID

2781498

14 September 2017

language of work or name

English

0 references

publication date

21 August 2009

1 reference

Journal of Biological Chemistry

14 September 2017

1 reference

14 September 2017

284

1 reference

14 September 2017

45

1 reference

14 September 2017

30974-30980

1 reference

Stabilising the DNA-binding domain of p53 by rational design of its hydrophobic core

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Structural biology of the tumor suppressor p53.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The biological impact of the human master regulator p53 can be altered by mutations that change the spectrum and expression of its target genes

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Solution structure of p53 core domain: structural basis for its instability

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The central region of HDM2 provides a second binding site for p53.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

p53 proteasomal degradation: poly-ubiquitination is not the whole story

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The ubiquitin ligase COP1 is a critical negative regulator of p53

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Endoproteolytic activity of the proteasome

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Rescuing the function of mutant p53.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

22 September 2017

Surfing the p53 network

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Mechanism of rescue of common p53 cancer mutations by second-site suppressor mutations

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Semirational design of active tumor suppressor p53 DNA binding domain with enhanced stability

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Identification of a novel p53 functional domain that is necessary for mediating apoptosis

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Thermodynamic stability of wild-type and mutant p53 core domain

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Regulation of p53 stability by Mdm2

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

mdm2 expression is induced by wild type p53 activity

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The p53-mdm-2 autoregulatory feedback loop

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

A temperature-sensitive mutant of human p53.

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

22 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Genetic selection of intragenic suppressor mutations that reverse the effect of common p53 cancer mutations

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The p73 DNA binding domain displays enhanced stability relative to its homologue, the tumor suppressor p53, and exhibits cooperative DNA binding.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Correlation of levels of folded recombinant p53 in escherichia coli with thermodynamic stability in vitro.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Proteasomal degradation of tau protein

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

The IARC TP53 database: new online mutation analysis and recommendations to users

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

20 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2781498

Rapid protein-folding assay using green fluorescent protein

20 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.033183

Kinetic Instability of p53 Core Domain Mutants

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M109.033183

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19700401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Stability and folding of the tumour suppressor protein p16

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19700401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Dual-site regulation of MDM2 E3-ubiquitin ligase activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19700401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.033183

1 reference

14 September 2017

1 reference

14 September 2017

1 reference

PMCID

2781498