(Q40064548)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

A review of candidate therapies for Middle East respiratory syndrome from a molecular perspective (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

Middle East respiratory syndrome coronavirus

28 March 2020

main subject

0 references

Middle East

0 references

Middle East respiratory syndrome

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

author name string

Shamsah H Alahmed

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Ali M Bazzi

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

Hatem M Alhani

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

publication date

31 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

Journal of Medical Microbiology

28 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

volume

66

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

page(s)

1261-1274

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

A truncated receptor-binding domain of MERS-CoV spike protein potently inhibits MERS-CoV infection and induces strong neutralizing antibody responses: implication for developing therapeutics and vaccines

28 March 2020

cites work

1 reference

12 December 2020

Prophylaxis With a Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-Specific Human Monoclonal Antibody Protects Rabbits From MERS-CoV Infection

1 reference

12 December 2020

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay.

1 reference

12 December 2020

3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012

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12 December 2020

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

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12 December 2020

Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients

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12 December 2020

Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission

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12 December 2020

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection

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12 December 2020

Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study.

1 reference

12 December 2020

Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen

1 reference

12 December 2020

Sensitivity of SARS/MERS CoV to interferons and other drugs based on achievable serum concentrations in humans

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12 December 2020

Adjunctive therapies and immunomodulating agents for severe influenza.

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12 December 2020

Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides.

1 reference

12 December 2020

Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4.

1 reference

12 December 2020

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines.

1 reference

12 December 2020

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

1 reference

12 December 2020

MERS-CoV vaccine candidates in development: The current landscape

1 reference

12 December 2020

Treatment strategies for Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

MERS coronavirus: diagnostics, epidemiology and transmission

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

1 reference

12 December 2020

The structural and accessory proteins M, ORF 4a, ORF 4b, and ORF 5 of Middle East respiratory syndrome coronavirus (MERS-CoV) are potent interferon antagonists

1 reference

12 December 2020

Preventing healthcare-associated transmission of the Middle East Respiratory Syndrome (MERS): Our Achilles heel.

1 reference

12 December 2020

A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein.

1 reference

12 December 2020

Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severity

1 reference

12 December 2020

Passive Transfer of A Germline-like Neutralizing Human Monoclonal Antibody Protects Transgenic Mice Against Lethal Middle East Respiratory Syndrome Coronavirus Infection

1 reference

12 December 2020

Corticosteroid treatment in critically ill patients with pandemic influenza A/H1N1 2009 infection: analytic strategy using propensity scores

1 reference

12 December 2020

Bioinformatics analysis on molecular mechanism of ribavirin and interferon-α in treating MERS-CoV

1 reference

12 December 2020

Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis

1 reference

12 December 2020

Treatment With Lopinavir/Ritonavir or Interferon-β1b Improves Outcome of MERS-CoV Infection in a Nonhuman Primate Model of Common Marmoset

1 reference

12 December 2020

Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein

1 reference

12 December 2020

Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies.

1 reference

12 December 2020

Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients

1 reference

12 December 2020

SARS: systematic review of treatment effects

1 reference

12 December 2020

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

1 reference

12 December 2020

High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

1 reference

12 December 2020

Coronaviruses - drug discovery and therapeutic options.

1 reference

12 December 2020

Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia

1 reference

12 December 2020

Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques

1 reference

12 December 2020

The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses.

1 reference

12 December 2020

The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis

1 reference

12 December 2020

Evaluation of candidate vaccine approaches for MERS-CoV.

1 reference

12 December 2020

Mechanisms of coronavirus cell entry mediated by the viral spike protein

1 reference

12 December 2020

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus.

1 reference

12 December 2020

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Small molecules targeting severe acute respiratory syndrome human coronavirus

1 reference

12 December 2020

Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol

1 reference

12 December 2020

Rooting the phylogenetic tree of middle East respiratory syndrome coronavirus by characterization of a conspecific virus from an African bat

1 reference

12 December 2020

Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV

1 reference

12 December 2020

Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection.

1 reference

12 December 2020

Rapid generation of a human monoclonal antibody to combat Middle East respiratory syndrome

1 reference

12 December 2020

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment

1 reference

12 December 2020

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

1 reference

12 December 2020

Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States

1 reference

12 December 2020

A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein.

1 reference

12 December 2020

Towards improving clinical management of Middle East respiratory syndrome coronavirus infection

1 reference

12 December 2020

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

1 reference

12 December 2020

Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa

1 reference

12 December 2020

Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study

1 reference

12 December 2020

An observational, laboratory-based study of outbreaks of middle East respiratory syndrome coronavirus in Jeddah and Riyadh, kingdom of Saudi Arabia, 2014.

1 reference

12 December 2020

Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study

1 reference

12 December 2020

Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation

1 reference

12 December 2020

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

1 reference

12 December 2020

Therapeutic options for Middle East respiratory syndrome coronavirus (MERS-CoV)--possible lessons from a systematic review of SARS-CoV therapy

1 reference

12 December 2020

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

1 reference

12 December 2020

Toward Developing a Preventive MERS-CoV Vaccine-Report from a Workshop Organized by the Saudi Arabia Ministry of Health and the International Vaccine Institute, Riyadh, Saudi Arabia, November 14-15, 2015.

1 reference

12 December 2020

Glycopeptide Antibiotics Potently Inhibit Cathepsin L in the Late Endosome/Lysosome and Block the Entry of Ebola Virus, Middle East Respiratory Syndrome Coronavirus (MERS-CoV), and Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV).

1 reference

12 December 2020

Protease inhibitors targeting coronavirus and filovirus entry

1 reference

12 December 2020

MERS-CoV spike protein: a key target for antivirals

1 reference

12 December 2020

Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Receptor-binding domain-based subunit vaccines against MERS-CoV

1 reference

12 December 2020

A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform.

1 reference

12 December 2020

Molecular Epidemiology of Hospital Outbreak of Middle East Respiratory Syndrome, Riyadh, Saudi Arabia, 2014.

1 reference

12 December 2020

A review of treatment modalities for Middle East Respiratory Syndrome

1 reference

12 December 2020

Human coronavirus EMC does not require the SARS-coronavirus receptor and maintains broad replicative capability in mammalian cell lines

1 reference

12 December 2020

Cross host transmission in the emergence of MERS coronavirus

1 reference

12 December 2020

Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors

1 reference

12 December 2020

X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design

1 reference

12 December 2020

Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans

1 reference

12 December 2020

Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: an in-vitro and ex-vivo study.

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.

1 reference

12 December 2020

Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4

1 reference

12 December 2020

Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection

1 reference

12 December 2020

Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin

1 reference

12 December 2020

Critical Assessment of the Important Residues Involved in the Dimerization and Catalysis of MERS Coronavirus Main Protease

1 reference

12 December 2020

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics

1 reference

12 December 2020

Treatment outcomes for patients with Middle Eastern Respiratory Syndrome Coronavirus (MERS CoV) infection at a coronavirus referral center in the Kingdom of Saudi Arabia

1 reference

12 December 2020

IFN-α2a or IFN-β1a in combination with ribavirin to treat Middle East respiratory syndrome coronavirus pneumonia: a retrospective study

1 reference

12 December 2020

Hospital outbreak of Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Middle East Respiratory Syndrome Coronavirus Efficiently Infects Human Primary T Lymphocytes and Activates the Extrinsic and Intrinsic Apoptosis Pathways

1 reference

12 December 2020

Thiopurine analogs and mycophenolic acid synergistically inhibit the papain-like protease of Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response.

1 reference

12 December 2020

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture

1 reference

12 December 2020

Cytokine responses in porcine respiratory coronavirus-infected pigs treated with corticosteroids as a model for severe acute respiratory syndrome

1 reference

12 December 2020

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

1 reference

12 December 2020

Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS.

1 reference

12 December 2020

2014 MERS-CoV outbreak in Jeddah--a link to health care facilities

1 reference

12 December 2020

Origin and Possible Genetic Recombination of the Middle East Respiratory Syndrome Coronavirus from the First Imported Case in China: Phylogenetics and Coalescence Analysis

1 reference

12 December 2020

Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids

1 reference

12 December 2020

Update on therapeutic options for Middle East Respiratory Syndrome Coronavirus (MERS-CoV).

1 reference

12 December 2020

Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission

1 reference

12 December 2020

State of Knowledge and Data Gaps of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Humans

1 reference

12 December 2020

Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation

1 reference

12 December 2020

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

1 reference

12 December 2020

Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features

1 reference

12 December 2020

Proteolytic processing, deubiquitinase and interferon antagonist activities of Middle East respiratory syndrome coronavirus papain-like protease

1 reference

12 December 2020

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

1 reference

12 December 2020

Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27

1 reference

12 December 2020

Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak control

1 reference

12 December 2020

Combination therapy with lopinavir/ritonavir, ribavirin and interferon-α for Middle East respiratory syndrome

1 reference

12 December 2020

Inhibition of Middle East respiratory syndrome coronavirus infection by anti-CD26 monoclonal antibody

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets

1 reference

12 December 2020

Notes from the Field: Nosocomial Outbreak of Middle East Respiratory Syndrome in a Large Tertiary Care Hospital--Riyadh, Saudi Arabia, 2015.

1 reference

12 December 2020

Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases

1 reference

12 December 2020

Delayed induction of proinflammatory cytokines and suppression of innate antiviral response by the novel Middle East respiratory syndrome coronavirus: implications for pathogenesis and treatment.

1 reference

12 December 2020

Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection

1 reference

12 December 2020

Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study.

1 reference

12 December 2020

The spike protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and is targeted by neutralizing antibodies

1 reference

12 December 2020

Identifiers

DOI

10.1099/JMM.0.000565

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28855003%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

PubMed publication ID

28855003

1 reference