(Q42265942)

19 October 2017

HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases (English)

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19 October 2017

Oliver T Fackler

5

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author name string

Xiaoyu Pan

1

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19 October 2017

Miriam M Geist

2

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19 October 2017

Jochen M Rudolph

3

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19 October 2017

Walter Nickel

4

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19 October 2017

3 May 2013

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19 October 2017

Cellular Microbiology

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19 October 2017

15

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19 October 2017

10

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19 October 2017

1605-1621

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HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

19 October 2017

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HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

21 January 2018

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Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes

21 January 2018

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An essential role for the MAL protein in targeting Lck to the plasma membrane of human T lymphocytes

21 January 2018

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A specific type of membrane microdomains is involved in the maintenance and translocation of kinase active Lck to lipid rafts.

21 January 2018

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Structure and regulation of Src family kinases

21 January 2018

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Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

21 January 2018

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A two-pronged mechanism for HIV-1 Nef-mediated endocytosis of immune costimulatory molecules CD80 and CD86.

21 January 2018

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HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux

21 January 2018

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

21 January 2018

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The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling

21 January 2018

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Differential T-cell antigen receptor signaling mediated by the Src family kinases Lck and Fyn.

21 January 2018

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Suppression of Tetherin-restricting activity upon human immunodeficiency virus type 1 particle release correlates with localization of Vpu in the trans-Golgi network

21 January 2018

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Live and let die: Nef functions beyond HIV replication

21 January 2018

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Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

21 January 2018

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

21 January 2018

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Structure--function relationships in HIV-1 Nef.

21 January 2018

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Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

21 January 2018

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Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

21 January 2018

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Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma

21 January 2018

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Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis

21 January 2018

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The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

21 January 2018

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HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

21 January 2018

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Interaction between Hck and HIV-1 Nef negatively regulates cell surface expression of M-CSF receptor.

21 January 2018

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HIV-1 Nef perturbs the function, structure, and signaling of the Golgi through the Src kinase Hck.

21 January 2018

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HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

21 January 2018

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Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

21 January 2018

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Importance of the nef gene for maintenance of high virus loads and for development of AIDS

21 January 2018

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

21 January 2018

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Role of Nef in primate lentiviral immunopathogenesis

21 January 2018

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Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

21 January 2018

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The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading

21 January 2018

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Functional roles for fatty acylated amino-terminal domains in subcellular localization

21 January 2018

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The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

21 January 2018

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Paxillin phosphorylation and association with Lck and Pyk2 in anti-CD3- or anti-CD45-stimulated T cells

21 January 2018

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HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

21 January 2018

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Src family kinases, key regulators of signal transduction

21 January 2018

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Adult AIDS-like disease in a novel inducible human immunodeficiency virus type 1 Nef transgenic mouse model: CD4+ T-cell activation is Nef dependent and can occur in the absence of lymphophenia

21 January 2018

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Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

21 January 2018

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Myristylation and palmitylation of Src family members: the fats of the matter

21 January 2018

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Phenotypic profiling of the human genome reveals gene products involved in plasma membrane targeting of SRC kinases

21 January 2018

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The palmitoylation machinery is a spatially organizing system for peripheral membrane proteins

21 January 2018

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

21 January 2018

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The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements

21 January 2018

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Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain

21 January 2018

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Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

21 January 2018

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Nef-Mediated Suppression of T Cell Activation Was Lost in a Lentiviral Lineage that Gave Rise to HIV-1

21 January 2018

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HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction

21 January 2018

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HIV Nef increases T cell ERK MAP kinase activity.

21 January 2018

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

21 January 2018

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p56Lck tyrosine kinase enhances the assembly of death-inducing signaling complex during Fas-mediated apoptosis.

21 January 2018

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Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

21 January 2018

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Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling

21 January 2018

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The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

21 January 2018

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Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.

21 January 2018

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HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

21 January 2018

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HIV-1 Nef impairs MHC class II antigen presentation and surface expression

21 January 2018

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Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse

21 January 2018

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SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility.

21 January 2018

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Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.

21 January 2018

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Inhibition of protein palmitoylation, raft localization, and T cell signaling by 2-bromopalmitate and polyunsaturated fatty acids.

21 January 2018

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Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck

21 January 2018

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Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

21 January 2018

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Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

21 January 2018

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Palmitoylation of p59fyn is reversible and sufficient for plasma membrane association

21 January 2018

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A kinase-independent function of Lck in potentiating antigen-specific T cell activation

21 January 2018

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Direct observation and quantitative analysis of Lck exchange between plasma membrane and cytosol in living T cells

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/CMI.12148

1 reference

release_5g3lcoowzvek3gijpa3vatrmtu

19 October 2017

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Fatcat

https://api.fatcat.wiki/v0/release/5g3lcoowzvek3gijpa3vatrmtu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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