(Q44420573)

2 December 2017

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation (English)

1 reference

2 December 2017

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

28 December 2023

nuclear protein

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

28 December 2023

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

28 December 2023

3

M. Oren

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

28 December 2023

author name string

X. Wang

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

28 December 2023

A. Zalcenstein

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

28 December 2023

language of work or name

1 reference

1 April 2003

1 reference

full work available at URL

2 December 2017

https://www.nature.com/articles/4401181.pdf

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12719724

http://www.nature.com/articles/4401181

28 December 2023

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

http://www.nature.com/articles/4401181.pdf

28 December 2023

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

Cell Death & Differentiation

28 December 2023

published in

1 reference

2 December 2017

10

1 reference

2 December 2017

4

1 reference

2 December 2017

468-476

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401181

2 December 2017

0 references

cites work

The chemistry of DNA damage from nitric oxide and peroxynitrite

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

S-nitrosylation: spectrum and specificity

21 January 2018

1 reference

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21 January 2018

1 reference

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Non-enzymatic nitric oxide synthesis in biological systems

21 January 2018

1 reference

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A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Multiple roles of the tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

The p53 and Mdm2 families in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

21 January 2018

Surfing the p53 network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Regulation of p53 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Regulation of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Activation of p53 by oncogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

DNA damage-induced activation of p53 by the checkpoint kinase Chk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

p53 expression in nitric oxide‐induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Intercellular signaling initiated by nitric oxide produced in heat-shocked human glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Transcription factors p53 and HIF-1alpha as targets of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nitric oxide-induced apoptosis in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Role of nitric oxide in carcinogenesis and tumour progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Induction of growth arrest by a temperature-sensitive p53 mutant is correlated with increased nuclear localization and decreased stability of the protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nasal polyp-derived superoxide anion: dose-dependent inhibition by nitric oxide and pathophysiological implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

DNA damage by nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Study on DNA strand breaks induced by sodium nitroprusside, a nitric oxide donor, in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

MDM2 can promote the ubiquitination, nuclear export, and degradation of p53 in the absence of direct binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Regulation of p53 function and stability by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nitric oxide protects thymocytes from gamma-irradiation-induced apoptosis in correlation with inhibition of p53 upregulation and mitochondrial damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

Nitric oxide prevents gamma-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

21 January 2018

The ins and outs of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

Stress-activated kinases regulate protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

Schedule and concentration-dependent induction of apoptosis in leukemia cells by nitric oxide

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

Zinc inhibits the nuclear translocation of the tumor suppressor protein p53 and protects cultured human neurons from copper-induced neurotoxicity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

Nitric oxide diminishes apoptosis and p53 gene expression after renal ischemia and reperfusion injury

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401181

7 January 2021

Journal of Biological Chemistry

38

26

26

X Wang

2002

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

28 December 2023

53

59

4375

JN Sarkaria

1999

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

28 December 2023

74

58

5637

CH Westphal

1998

1 reference

https://api.crossref.org/works/10.1038/SJ.CDD.4401181

28 December 2023

Identifiers

1 reference

2 December 2017

1 reference