(Q45028072)

8 December 2017

title

Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues (English)

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8 December 2017

5

Ina L Urbatsch

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8 December 2017

Gregory Tombline

1

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8 December 2017

Lori A Bartholomew

2

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8 December 2017

Grace A Tyndall

3

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8 December 2017

Khursheed Gimi

4

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8 December 2017

Alan E Senior

6

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8 December 2017

language of work or name

English

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publication date

23 August 2004

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Journal of Biological Chemistry

8 December 2017

published in

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8 December 2017

volume

279

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8 December 2017

issue

45

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8 December 2017

page(s)

46518-46526

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

8 December 2017

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1 reference

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The catalytic cycle of P-glycoprotein

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The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism

21 January 2018

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The mechanism of action of multidrug-resistance-linked P-glycoprotein

21 January 2018

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Conserved walker A Ser residues in the catalytic sites of P-glycoprotein are critical for catalysis and involved primarily at the transition state step.

21 January 2018

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P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state

21 January 2018

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Stoichiometry and affinity of nucleotide binding to P-glycoprotein during the catalytic cycle

21 January 2018

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Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.

21 January 2018

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The "LSGGQ" motif in each nucleotide-binding domain of human P-glycoprotein is adjacent to the opposing walker A sequence

21 January 2018

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Cysteines 431 and 1074 are responsible for inhibitory disulfide cross-linking between the two nucleotide-binding sites in human P-glycoprotein

21 January 2018

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ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

21 January 2018

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The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

21 January 2018

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A Tweezers-like Motion of the ATP-Binding Cassette Dimer in an ABC Transport Cycle

21 January 2018

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

21 January 2018

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Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter

21 January 2018

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Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

21 January 2018

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Formation of the productive ATP-Mg2+-bound dimer of GlcV, an ABC-ATPase from Sulfolobus solfataricus

21 January 2018

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The ATP hydrolysis cycle of the nucleotide-binding domain of the mitochondrial ATP-binding cassette transporter Mdl1p.

21 January 2018

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Structure of the recA protein–ADP complex

21 January 2018

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Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria

21 January 2018

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Binding of the transition state analog MgADP-fluoroaluminate to F1-ATPase

21 January 2018

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Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis

21 January 2018

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Spatial precision of a catalytic carboxylate of F1-ATPase beta subunit probed by introducing different carboxylate-containing side chains

21 January 2018

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Crystal structure of the ATP-binding subunit of an ABC transporter

21 January 2018

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Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein

21 January 2018

1 reference

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Structural and functional asymmetry of the nucleotide-binding domains of P-glycoprotein investigated by attenuated total reflection Fourier transform infrared spectroscopy

21 January 2018

1 reference

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Analysis of catalytic carboxylate mutants E552Q and E1197Q suggests asymmetric ATP hydrolysis by the two nucleotide-binding domains of P-glycoprotein

21 January 2018

1 reference

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Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408052200

Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408052200

Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408052200

A common mechanism for ATP hydrolysis in ABC transporter and helicase superfamilies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408052200

The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408052200

21 January 2018

Identifiers

DOI

10.1074/JBC.M408052200

1 reference

8 December 2017

1 reference