(Q45290815)

11 December 2017

title

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat. (English)

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11 December 2017

16

Olaf Riess

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11 December 2017

17

Huu P Nguyen

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11 December 2017

4

Libo Yu-Taeger

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11 December 2017

6

Carsten Calaminus

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11 December 2017

2

Jonasz J Weber

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11 December 2017

10

Janine C D Magg

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11 December 2017

Laura E Clemens

1

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11 December 2017

Tanja T Wlodkowski

3

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11 December 2017

Magali Michaud

5

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11 December 2017

Schamim H Eckert

7

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11 December 2017

Janett Gaca

8

1 reference

11 December 2017

Andreas Weiss

9

1 reference

11 December 2017

Erik K H Jansson

11

1 reference

11 December 2017

Gunter P Eckert

12

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11 December 2017

Bernd J Pichler

13

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11 December 2017

Thierry Bordet

14

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11 December 2017

Rebecca M Pruss

15

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11 December 2017

language of work or name

English

0 references

publication date

21 October 2015

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11 December 2017

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11 December 2017

volume

138

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11 December 2017

issue

Pt 12

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11 December 2017

page(s)

3632-3653

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Reversal learning and associative memory impairments in a BACHD rat model for Huntington disease

11 December 2017

cites work

1 reference

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Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for huntington disease.

21 January 2018

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Protein aggregates in Huntington's disease.

21 January 2018

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Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death

21 January 2018

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Calpain 10: a mitochondrial calpain and its role in calcium-induced mitochondrial dysfunction

21 January 2018

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N terminus of calpain 1 is a mitochondrial targeting sequence

21 January 2018

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p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

21 January 2018

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TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease

21 January 2018

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mTOR signaling contributes to motor skill learning in mice

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Olesoxime (TRO19622): A Novel Mitochondrial-Targeted Neuroprotective Compound

21 January 2018

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Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy

21 January 2018

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Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis

21 January 2018

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Mitochondrial Ca(2+) and neurodegeneration

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A behavioral comparison of the common laboratory rat strains Lister Hooded, Lewis, Fischer 344 and Wistar in an automated homecage system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Shaping the role of mitochondria in the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

An updated patent review of calpain inhibitors (2012 - 2014).

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mitochondrial membrane fluidity is consistently increased in different models of Huntington disease: restorative effects of olesoxime

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Impaired regulation of brain mitochondria by extramitochondrial Ca2+ in transgenic Huntington disease rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

The regulation of OXPHOS by extramitochondrial calcium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calcineurin controls inositol 1,4,5-trisphosphate type 1 receptor expression in neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Protective role of olesoxime against wild-type α-synuclein-induced toxicity in human neuronally differentiated SHSY-5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Inhibition of Drp1 provides neuroprotection in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

The influence of huntingtin protein size on nuclear localization and cellular toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

The mitochondrial inner membrane GTPase, optic atrophy 1 (Opa1), restores mitochondrial morphology and promotes neuronal survival following excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Reduced motivation in the BACHD rat model of Huntington disease is dependent on the choice of food deprivation strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Carbamazepine suppresses calpain-mediated autophagy impairment after ischemia/reperfusion in mouse livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor impairs ER Ca(2+) buffering and causes neurodegeneration in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Evaluation of mitochondrial respiratory function in small biopsies of liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Proteolysis of mutant huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mitochondrial calcium and the permeability transition in cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Aggregation of N-terminal huntingtin is dependent on the length of its glutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Corticostriatal circuit dysfunction in Huntington's disease: intersection of glutamate, dopamine and calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Matrix Metalloproteinases Are Modifiers of Huntingtin Proteolysis and Toxicity in Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Coupling of ryanodine receptor 2 and voltage-dependent anion channel 2 is essential for Ca²+ transfer from the sarcoplasmic reticulum to the mitochondria in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Imaging polyglutamine deposits in brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Recent advances on the pathogenesis of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Chronic administration of cholesterol oximes in mice increases transcription of cytoprotective genes and improves transcriptome alterations induced by alpha-synuclein overexpression in nigrostriatal dopaminergic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain as a potential therapeutic target in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Excitotoxic lesions of the medial prefrontal cortex attenuate fear responses in the elevated-plus maze, social interaction and shock probe burying tests

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpains, mitochondria, and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A role for α4(non-α6)* nicotinic acetylcholine receptors in motor behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Role of calpain-1 in the early phase of experimental ALS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Disturbed Ca2+ signaling and apoptosis of medium spiny neurons in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Cognitive dysfunction precedes neuropathology and motor abnormalities in the YAC128 mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Effects of overexpression of huntingtin proteins on mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Mutant huntingtin fragmentation in immune cells tracks Huntington's disease progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington's disease patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Control of basal autophagy by calpain1 mediated cleavage of ATG5

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Olesoxime (cholest-4-en-3-one, oxime): analgesic and neuroprotective effects in a rat model of painful peripheral neuropathy produced by the chemotherapeutic agent, paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Characterization of oxaliplatin-induced chronic painful peripheral neuropathy in the rat and comparison with the neuropathy induced by paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Inhibition of mitochondrial protein import by mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A novel BACHD transgenic rat exhibits characteristic neuropathological features of Huntington disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

IL-17A contributes to brain ischemia reperfusion injury through calpain-TRPC6 pathway in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

A phase II−III trial of olesoxime in subjects with amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWV290

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWV290

1 reference

11 December 2017

1 reference