(Q46121560)

19 December 2017

title

Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes (English)

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19 December 2017

main subject

Beta-secretase 2

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GOA release 2020-03-11

5

Christian Haass

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author name string

Frauke van Bebber

1

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19 December 2017

Alexander Hruscha

2

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19 December 2017

Michael Willem

3

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19 December 2017

Bettina Schmid

4

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19 December 2017

language of work or name

English

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publication date

11 March 2013

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19 December 2017

Journal of Neurochemistry

published in

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19 December 2017

volume

127

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19 December 2017

issue

4

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19 December 2017

page(s)

471-481

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19 December 2017

Expression analysis of BACE2 in brain and peripheral tissues

cites work

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Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.

21 January 2018

1 reference

β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment

21 January 2018

1 reference

Beta-secretase as a target for the treatment of Alzheimer's disease

21 January 2018

1 reference

Emerging Alzheimer's disease therapies: inhibition of beta-secretase

21 January 2018

1 reference

Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice

21 January 2018

1 reference

Neuregulins and the neuromuscular system: 10 years of answers and questions

21 January 2018

1 reference

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

21 January 2018

1 reference

Migration and function of a glial subtype in the vertebrate peripheral nervous system.

21 January 2018

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

21 January 2018

1 reference

The amyloid hypothesis for Alzheimer's disease: a critical reappraisal

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes

21 January 2018

1 reference

β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

21 January 2018

1 reference

Bace1 modulates myelination in the central and peripheral nervous system.

21 January 2018

1 reference

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

21 January 2018

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BACE1 deficiency causes altered neuronal activity and neurodegeneration

21 January 2018

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

21 January 2018

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BACE1 regulates voltage-gated sodium channels and neuronal activity

21 January 2018

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Reduced sodium channel Na(v)1.1 levels in BACE1-null mice

21 January 2018

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Stages of embryonic development of the zebrafish

21 January 2018

1 reference

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

21 January 2018

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Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase

21 January 2018

1 reference

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

21 January 2018

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TACE (ADAM17) inhibits Schwann cell myelination

21 January 2018

1 reference

BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions.

21 January 2018

1 reference

The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.

21 January 2018

1 reference

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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Robust central reduction of amyloid-β in humans with an orally available, non-peptidic β-secretase inhibitor

21 January 2018

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Axonal neuregulin-1 regulates myelin sheath thickness

21 January 2018

1 reference

Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish.

21 January 2018

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BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

21 January 2018

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Neuronal Neuregulin 1 type III directs Schwann cell migration

21 January 2018

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The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

21 January 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

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Neuregulin-1 type III determines the ensheathment fate of axons

21 January 2018

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Genome editing with engineered zinc finger nucleases

21 January 2018

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The morphology and mechanical sensitivity of lateral line receptors in zebrafish larvae (Danio rerio).

21 January 2018

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The beta-secretase, BACE: a prime drug target for Alzheimer's disease

21 January 2018

1 reference

Beta-secretase (BACE) as a drug target for Alzheimer's disease

21 January 2018

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Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination

21 January 2018

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Phosphorylation regulates intracellular trafficking of beta-secretase

21 January 2018

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Control of peripheral nerve myelination by the beta-secretase BACE1

21 January 2018

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beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis.

21 January 2018

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The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JNC.12198

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19 December 2017

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19 December 2017