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The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation.
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20 March 2020
title
The amyloid-β oligomer Aβ*56 induces specific alterations in neuronal signaling that lead to tau phosphorylation and aggregation
(English)
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Europe PubMed Central
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5859319
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20 March 2020
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phosphorylation
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Fatou Amar
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1
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Europe PubMed Central
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5859319
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20 March 2020
Travis Rush
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3
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Europe PubMed Central
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5859319
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20 March 2020
Megan Larson
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4
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20 March 2020
Gabriel Boyle
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5
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20 March 2020
Liu Chang
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6
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5859319
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20 March 2020
Jürgen Götz
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7
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5859319
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20 March 2020
Alain Buisson
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8
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20 March 2020
Sylvain Lesné
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9
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20 March 2020
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Mathew A Sherman
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2
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5859319
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20 March 2020
publication date
9 May 2017
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20 March 2020
published in
Science Signaling
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5859319
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20 March 2020
volume
10
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Europe PubMed Central
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5859319
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20 March 2020
issue
478
1 reference
stated in
Europe PubMed Central
PMCID
5859319
reference URL
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20 March 2020
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Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
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Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.
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Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.
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15 August 2018
Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers.
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15 August 2018
Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles
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15 August 2018
Reduction of NR1 and phosphorylated Ca2+/calmodulin-dependent protein kinase II levels in Alzheimer's disease
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15 August 2018
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Hierarchical phosphorylation of recombinant tau by the paired-helical filament-associated protein kinase is dependent on cyclic AMP-dependent protein kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5859319
retrieved
15 August 2018
Identifiers
DOI
10.1126/SCISIGNAL.AAL2021
1 reference
stated in
Europe PubMed Central
PMCID
5859319
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28487416%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PMCID
5859319
1 reference
stated in
Europe PubMed Central
PMCID
5859319
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28487416%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PubMed ID
28487416
1 reference
stated in
Europe PubMed Central
PMCID
5859319
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28487416%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
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