(Q47594679)

4 February 2018

title

CRISPR/Cas9-Based Engineering of the Epigenome (English)

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4 February 2018

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4 February 2018

Ángel Raya

5

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4 February 2018

Julian Pulecio

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Julian Pulecio

1

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Eva Mejía-Ramírez

object named as

Eva Mejía-Ramírez

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author name string

Nipun Verma

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4 February 2018

language of work or name

English

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publication date

1 October 2017

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4 February 2018

published in

Cell Stem Cell

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4 February 2018

volume

21

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4 February 2018

issue

4

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4 February 2018

page(s)

431-447

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4 February 2018

Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening

cites work

1 reference

12 December 2020

Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes

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12 December 2020

Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system

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12 December 2020

Live cell imaging of repetitive DNA sequences via GFP-tagged polydactyl zinc finger proteins

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12 December 2020

Long-term dual-color tracking of genomic loci by modified sgRNAs of the CRISPR/Cas9 system.

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12 December 2020

Krüppel-associated box-mediated repression of RNA polymerase II promoters is influenced by the arrangement of basal promoter elements

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12 December 2020

Multiplexed and programmable regulation of gene networks with an integrated RNA and CRISPR/Cas toolkit in human cells.

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12 December 2020

Integrative analysis of 111 reference human epigenomes

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12 December 2020

Pooled CRISPR screening with single-cell transcriptome readout

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12 December 2020

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy.

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12 December 2020

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

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12 December 2020

Illuminating DNA replication during Drosophila development using TALE-lights

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12 December 2020

High-throughput functional genomics using CRISPR-Cas9.

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12 December 2020

Genome-scale CRISPR-Cas9 knockout screening in human cells

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12 December 2020

Chromatin modifiers and remodellers: regulators of cellular differentiation

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12 December 2020

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

1 reference

12 December 2020

CBP/p300 in cell growth, transformation, and development

1 reference

12 December 2020

Epigenetic modifications as therapeutic targets

1 reference

12 December 2020

Functional annotation of native enhancers with a Cas9-histone demethylase fusion.

1 reference

12 December 2020

Chromosomal inheritance of epigenetic states in fission yeast during mitosis and meiosis

1 reference

12 December 2020

Histone H3 globular domain acetylation identifies a new class of enhancers

1 reference

12 December 2020

CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter.

1 reference

12 December 2020

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

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12 December 2020

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

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12 December 2020

Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner

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12 December 2020

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq

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12 December 2020

Direct conversion of fibroblasts into functional astrocytes by defined transcription factors

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12 December 2020

RNA-mediated epigenetic regulation of gene expression

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12 December 2020

Optimizing sgRNA position markedly improves the efficiency of CRISPR/dCas9-mediated transcriptional repression

1 reference

12 December 2020

The cell biology of genomes: bringing the double helix to life.

1 reference

12 December 2020

CRISPR/dCas9-mediated Transcriptional Inhibition Ameliorates the Epigenetic Dysregulation at D4Z4 and Represses DUX4-fl in FSH Muscular Dystrophy

1 reference

12 December 2020

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

1 reference

12 December 2020

Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling

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12 December 2020

Live visualization of chromatin dynamics with fluorescent TALEs

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12 December 2020

Epigenomic analysis of multilineage differentiation of human embryonic stem cells

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12 December 2020

Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein

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12 December 2020

Dynamics of relative chromosome position during the cell cycle

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12 December 2020

Epigenome-wide association studies for common human diseases

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12 December 2020

The long-range interaction landscape of gene promoters

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12 December 2020

Expanding the CRISPR imaging toolset with Staphylococcus aureus Cas9 for simultaneous imaging of multiple genomic loci

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12 December 2020

Enhancers: the abundance and function of regulatory sequences beyond promoters

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12 December 2020

Efficient isolation of specific genomic regions and identification of associated proteins by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR.

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12 December 2020

Advances in targeted genome editing

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12 December 2020

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells

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12 December 2020

Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system.

1 reference

12 December 2020

ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus

1 reference

12 December 2020

Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

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12 December 2020

Forcing cells to change lineages

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12 December 2020

Multiplexable, locus-specific targeting of long RNAs with CRISPR-Display

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12 December 2020

Visualization of Genomic Loci in Living Cells with a Fluorescent CRISPR/Cas9 System.

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12 December 2020

Multiplexed labeling of genomic loci with dCas9 and engineered sgRNAs using CRISPRainbow.

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12 December 2020

Depletion of histone demethylase KDM2A inhibited cell proliferation of stem cells from apical papilla by de-repression of p15INK4B and p27Kip1.

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12 December 2020

Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

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12 December 2020

A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice

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12 December 2020

In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition

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12 December 2020

A CRISPR-based approach for proteomic analysis of a single genomic locus

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12 December 2020

Editing the epigenome: technologies for programmable transcription and epigenetic modulation

1 reference

12 December 2020

Prader-Willi and Angelman syndromes. Disorders of genomic imprinting

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12 December 2020

A novel cell-permeable, selective, and noncompetitive inhibitor of KAT3 histone acetyltransferases from a combined molecular pruning/classical isosterism approach.

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12 December 2020

Mutations in the noncoding genome

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12 December 2020

DNA methylation: roles in mammalian development

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12 December 2020

Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation.

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12 December 2020

Genetic interaction mapping in mammalian cells using CRISPR interference

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12 December 2020

CRISPR reveals a distal super-enhancer required for Sox2 expression in mouse embryonic stem cells

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12 December 2020

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

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12 December 2020

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

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12 December 2020

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

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12 December 2020

Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing

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12 December 2020

CRISPR-Cas9-based photoactivatable transcription system.

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12 December 2020

Differences in the localization and morphology of chromosomes in the human nucleus.

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12 December 2020

DNA methylation on N(6)-adenine in mammalian embryonic stem cells

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12 December 2020

Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas

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12 December 2020

Targeting and tracing of specific DNA sequences with dTALEs in living cells.

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12 December 2020

A protein-tagging system for signal amplification in gene expression and fluorescence imaging

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12 December 2020

A CRISPR-based approach for targeted DNA demethylation

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12 December 2020

In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9

1 reference

12 December 2020

The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a

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12 December 2020

An integrated encyclopedia of DNA elements in the human genome

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12 December 2020

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

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12 December 2020

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

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12 December 2020

Cooperation between SMYD3 and PC4 drives a distinct transcriptional program in cancer cells

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12 December 2020

A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening

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12 December 2020

Transcriptional and epigenetic dynamics during specification of human embryonic stem cells

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12 December 2020

Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC

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12 December 2020

Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B.

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12 December 2020

Genetic screens in human cells using the CRISPR-Cas9 system

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12 December 2020

Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators

1 reference

12 December 2020

Repurposing the CRISPR-Cas9 system for targeted DNA methylation

1 reference

12 December 2020

Targeted DNA methylation in human cells using engineered dCas9-methyltransferases.

1 reference

12 December 2020

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

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12 December 2020

Phylogeny of Cas9 determines functional exchangeability of dual-RNA and Cas9 among orthologous type II CRISPR-Cas systems

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12 December 2020

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

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12 December 2020

Epigenetics. Epigenetic inheritance uncoupled from sequence-specific recruitment

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12 December 2020

TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

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12 December 2020

Transient Kinetics Define a Complete Kinetic Model for Protein Arginine Methyltransferase 1.

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12 December 2020

Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors.

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12 December 2020

Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation.

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12 December 2020

KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading

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12 December 2020

HistoneHits: a database for histone mutations and their phenotypes

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12 December 2020

Complex transcriptional modulation with orthogonal and inducible dCas9 regulators.

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12 December 2020

MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency

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12 December 2020

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

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12 December 2020

Transgenerational transmission of environmental information in C. elegans

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12 December 2020

Isolation of specific genomic regions and identification of associated molecules by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR.

1 reference

12 December 2020

A CRISPR/Cas9-based system for reprogramming cell lineage specification.

1 reference

12 December 2020

Multiplex genome engineering in human cells using all-in-one CRISPR/Cas9 vector system

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12 December 2020

Chromatin modifications and their function

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12 December 2020

The molecular hallmarks of epigenetic control

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12 December 2020

Chromosome organization by a nucleoid-associated protein in live bacteria

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12 December 2020

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

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12 December 2020

CRISPR RNA-guided activation of endogenous human genes

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12 December 2020

CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome

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12 December 2020

Reprogramming human fibroblasts to pluripotency using modified mRNA.

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12 December 2020

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

1 reference

12 December 2020

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion

1 reference

12 December 2020

eRNAs are required for p53-dependent enhancer activity and gene transcription

1 reference

12 December 2020

Classification and evolution of type II CRISPR-Cas systems

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12 December 2020

LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells.

1 reference

12 December 2020

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

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12 December 2020

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

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12 December 2020

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

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12 December 2020

Targeted Epigenetic Remodeling of Endogenous Loci by CRISPR/Cas9-Based Transcriptional Activators Directly Converts Fibroblasts to Neuronal Cells

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12 December 2020

Epigenetics. Restricted epigenetic inheritance of H3K9 methylation.

1 reference

12 December 2020

Epigenetic germline inheritance of diet-induced obesity and insulin resistance.

1 reference

12 December 2020

Direct detection of DNA methylation during single-molecule, real-time sequencing

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12 December 2020

A decade of 3C technologies: insights into nuclear organization

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12 December 2020

Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy.

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12 December 2020

An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells

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12 December 2020

Development and applications of CRISPR-Cas9 for genome engineering

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12 December 2020

Role of TET enzymes in DNA methylation, development, and cancer

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12 December 2020

Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions

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12 December 2020

CpG islands in vertebrate genomes

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12 December 2020

Reversing DNA methylation: mechanisms, genomics, and biological functions

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12 December 2020

X chromosome inactivation is mediated by Xist RNA stabilization

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12 December 2020

The function of non-coding RNAs in genomic imprinting

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12 December 2020

High-resolution interrogation of functional elements in the noncoding genome

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12 December 2020

Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors

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12 December 2020

A light-inducible CRISPR-Cas9 system for control of endogenous gene activation

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12 December 2020

Identification and characterization of a FOXA2-regulated transcriptional enhancer at a type 2 diabetes intronic locus that controls GCKR expression in liver cells

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12 December 2020

Single-cell dynamics of genome-nuclear lamina interactions

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12 December 2020

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

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12 December 2020

Cas9 as a versatile tool for engineering biology

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12 December 2020

RNA is an integral component of chromatin that contributes to its structural organization

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12 December 2020

Beyond the sequence: cellular organization of genome function

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12 December 2020

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

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12 December 2020

Chromatin regulation at the frontier of synthetic biology

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12 December 2020

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

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12 December 2020

Multiplex genome engineering using CRISPR/Cas systems

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12 December 2020

Translating the Histone Code

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12 December 2020

Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells

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12 December 2020

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

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12 December 2020

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers.

1 reference

12 December 2020

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

1 reference

12 December 2020

Zfp281 Coordinates Opposing Functions of Tet1 and Tet2 in Pluripotent States.

1 reference

12 December 2020

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

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12 December 2020

Comparison of Cas9 activators in multiple species

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12 December 2020

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

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12 December 2020

Generation of induced pluripotent stem cells (iPSCs) stably expressing CRISPR-based synergistic activation mediator (SAM).

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12 December 2020

Development of a mono-promoter-driven CRISPR/Cas9 system in mammalian cells.

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12 December 2020

Systematic localization of common disease-associated variation in regulatory DNA

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12 December 2020

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

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12 December 2020

Direct Conversion of Fibroblasts to Megakaryocyte Progenitors

1 reference

12 December 2020

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens

1 reference

12 December 2020

ChromHMM: automating chromatin-state discovery and characterization

1 reference

12 December 2020

Multicolor CRISPR labeling of chromosomal loci in human cells.

1 reference

12 December 2020

Systematic mapping of functional enhancer-promoter connections with CRISPR interference

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12 December 2020

The DNA methyltransferases of mammals

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12 December 2020

Conversion of human fibroblasts into monocyte-like progenitor cells

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12 December 2020

The BioGRID Interaction Database: 2011 update

1 reference

12 December 2020

Engineering complex synthetic transcriptional programs with CRISPR RNA scaffolds

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12 December 2020

Controlling transcription in human pluripotent stem cells using CRISPR-effectors.

1 reference

12 December 2020

Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression

1 reference

12 December 2020

High-throughput mapping of regulatory DNA.

1 reference

12 December 2020

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

1 reference

12 December 2020

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems

1 reference

12 December 2020

Editing DNA Methylation in the Mammalian Genome

1 reference

12 December 2020

The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis

1 reference

12 December 2020

In vivo gene editing in dystrophic mouse muscle and muscle stem cells

1 reference

12 December 2020

Dynamics of CRISPR-Cas9 genome interrogation in living cells

1 reference

12 December 2020

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase

1 reference

12 December 2020

Long noncoding RNAs may alter chromosome's 3D structure.

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12 December 2020

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

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12 December 2020

Discovery of stimulation-responsive immune enhancers with CRISPR activation.

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12 December 2020

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.

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12 December 2020

10.1016/J.STEM.2017.09.006

Identifiers

DOI

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4 February 2018

PMC publication ID

6205890

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1 reference

4 February 2018