(Q47935295)

6 February 2018

http://europepmc.org/abstract/MED/28820879

title

A kinetic view of GPCR allostery and biased agonism (English)

1 reference

6 February 2018

http://europepmc.org/abstract/MED/28820879

author

Robert G. Parton

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Patrick M. Sexton

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

J. Robert Lane

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Lauren T May

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Arthur Christopoulos

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

publication date

1 August 2017

1 reference

6 February 2018

http://europepmc.org/abstract/MED/28820879

published in

Nature Chemical Biology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

929-937

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

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10 June 2020

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Both ligand- and cell-specific parameters control ligand agonism in a kinetic model of g protein-coupled receptor signaling

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The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist

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Structure of an agonist-bound human A2A adenosine receptor

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Crystal structure of the β2 adrenergic receptor-Gs protein complex

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Crystal structure of the human beta2 adrenergic G-protein-coupled receptor

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Functional efficacy of adenosine A₂A receptor agonists is positively correlated to their receptor residence time

21 January 2018

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Long Receptor Residence Time of C26 Contributes to Super Agonist Activity at the Human β2 Adrenoceptor.

21 January 2018

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The role of kinetic context in apparent biased agonism at GPCRs

21 January 2018

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Novel Allosteric Modulators of G Protein-coupled Receptors

21 January 2018

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Endogenous allosteric modulators of G protein-coupled receptors

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G protein-coupled receptor allosterism and complexing

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Structural Features for Functional Selectivity at Serotonin Receptors

21 January 2018

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Structural Basis for Molecular Recognition at Serotonin Receptors

21 January 2018

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A structure-activity analysis of biased agonism at the dopamine D2 receptor

21 January 2018

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Structure-activity relationships and discovery of a G protein biased μ opioid receptor ligand, [(3-methoxythiophen-2-yl)methyl]({2-[(9R)-9-(pyridin-2-yl)-6-oxaspiro-[4.5]decan-9-yl]ethyl})amine (TRV130), for the treatment of acute severe pain.

21 January 2018

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21 January 2018

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21 January 2018

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Endosomes: a legitimate platform for the signaling train

21 January 2018

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Conformational biosensors reveal GPCR signalling from endosomes.

21 January 2018

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Endosomal generation of cAMP in GPCR signaling

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Quantifying ligand bias at seven-transmembrane receptors.

21 January 2018

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Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)

21 January 2018

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21 January 2018

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Agonists for the adenosine A1 receptor with tunable residence time. A Case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines.

21 January 2018

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Structure-kinetic relationship study of CDK8/CycC specific compounds

21 January 2018

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Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action

21 January 2018

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Drug-target residence time--a case for G protein-coupled receptors

21 January 2018

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Ba 679 BR, a novel long-acting anticholinergic bronchodilator

21 January 2018

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Targeting the dopamine D2 receptor in schizophrenia

21 January 2018

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Analytical pharmacology: the impact of numbers on pharmacology

21 January 2018

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7 January 2021

A theory of drug action based on the rate of drug-receptor combination

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7 January 2021

Seven helix receptors are enzymes catalysing G protein activation. What is the agonist Kact?

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7 January 2021

Structure-kinetics relationships of Capadenoson derivatives as adenosine A 1 receptor agonists

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7 January 2021

Allosteric modulation of A2A adenosine receptors by amiloride analogues and sodium ions

1 reference

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7 January 2021

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

1 reference

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7 January 2021

Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation.

1 reference

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7 January 2021

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

1 reference

12 December 2020

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

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12 December 2020

The kinetics of competitive radioligand binding predicted by the law of mass action.

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12 December 2020

Modification of the binding properties of muscarinic receptors by gallamine

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12 December 2020

A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model

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12 December 2020

Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors

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12 December 2020

Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes

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12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.2431

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28820879%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 June 2020

1091241015

0 references

Fatcat ID

release_i7s3dvlqbrgkjb6s4mel53vmsi

0 references

1 reference