(Q48747209)

http://europepmc.org/abstract/MED/27815544

15 February 2018

review article

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title

Functional Genomic Characterization of Cancer Genomes. (English)

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http://europepmc.org/abstract/MED/27815544

15 February 2018

1 reference

3

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4 June 2020

Thomas P Howard

1

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4 June 2020

Francisca Vazquez

2

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4 June 2020

Andrew L Hong

4

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4 June 2020

8

William C Hahn

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4 June 2020

7

Jesse S Boehm

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4 June 2020

author name string

Mik Rinne

5

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4 June 2020

Andrew J Aguirre

6

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4 June 2020

publication date

4 November 2016

1 reference

http://europepmc.org/abstract/MED/27815544

15 February 2018

published in

Cold Spring Harbor Symposia on Quantitative Biology

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4 June 2020

volume

81

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4 June 2020

page(s)

237-246

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27815544%20AND%20SRC:MED&resulttype=core&format=json

Genomic Copy Number Dictates a Gene-Independent Cell Response to CRISPR/Cas9 Targeting

4 June 2020

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Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

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Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers

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Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

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Drugging the undruggable RAS: Mission possible?

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Evaluating cell lines as tumour models by comparison of genomic profiles

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In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene

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Minimizing the risk of reporting false positives in large-scale RNAi screens

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Lessons from the cancer genome

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Rare cancers are not so rare: the rare cancer burden in Europe.

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The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

21 January 2018

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Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

21 January 2018

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Systematic interrogation of 3q26 identifies TLOC1 and SKIL as cancer drivers.

21 January 2018

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Hallmarks of Cancer: The Next Generation

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Vulnerabilities of mutant SWI/SNF complexes in cancer.

21 January 2018

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ARID1B is a specific vulnerability in ARID1A-mutant cancers.

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

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Integrated genetic and pharmacologic interrogation of rare cancers

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Development and applications of CRISPR-Cas9 for genome engineering

21 January 2018

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

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Expression profiling reveals off-target gene regulation by RNAi

21 January 2018

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Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 January 2018

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

21 January 2018

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RNA-programmed genome editing in human cells

21 January 2018

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The concept of synthetic lethality in the context of anticancer therapy

21 January 2018

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Molecular biology. Use and abuse of RNAi to study mammalian gene function

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Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles

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Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

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21 January 2018

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

21 January 2018

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The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer

21 January 2018

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21 January 2018

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Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4

21 January 2018

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Human ORFeome version 1.1: a platform for reverse proteomics

21 January 2018

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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells

21 January 2018

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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

21 January 2018

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Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

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ATARiS: computational quantification of gene suppression phenotypes from multisample RNAi screens

21 January 2018

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Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy

21 January 2018

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Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

21 January 2018

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21 January 2018

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Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

21 January 2018

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The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

21 January 2018

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21 January 2018

Cancer genome landscapes

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Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

21 January 2018

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Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

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Identification and characterization of essential genes in the human genome.

21 January 2018

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A genetic screen for candidate tumor suppressors identifies REST

21 January 2018

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SWI/SNF nucleosome remodellers and cancer.

21 January 2018

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Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

21 January 2018

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A public genome-scale lentiviral expression library of human ORFs

21 January 2018

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

21 January 2018

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

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An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

21 January 2018

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10.1101/SQB.2016.81.031070

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27815544%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference